Abstract
Around 10–15 % of epithelial ovarian cancers have histological and clinical behavior that are intermediate among benign and malignant tumors. These low malignant potential (LMP) tumors, also called borderline, were firstly described by Taylor in 1929. These neoplasms have a more favorable outcome than malignant ovarian cancers, but they were considered comprehensively by the International Federation of Gynecology and Obstetrics (FIGO) and the World Health Organization (WHO) until the early 1970s. Although LMP tumors may develop at any age, patients are usually in their 40s, about 15–20 years younger than women with invasive ovarian cancer, and the large majority of LMP tumors is discovered at stage I. Surgery is the treatment of choice, and the conservative strategy is strongly increasing in the last years. They often have a good prognosis, but because of many reasons, their management is frequently problematic.
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References
Huusom LD, Frederiksen K, Hogdall EV et al (2006) Association of reproductive factors, oral contraceptive use and selected lifestyle factors with the risk of ovarian borderline tumors: a Danish case–control study. Cancer Causes Control 17:821
Prat J, Ribé A, Gallardo A (2005) Hereditary ovarian cancer. Hum Pathol 36(8):861–870
Kurman RJ, Shih I (2011) Molecular pathogenesis and extra-ovarian origin of epithelial ovarian cancer–shifting the paradigm. Hum Pathol 42:918–931
Kurman RJ (2013) Origin and molecular pathogenesis of ovarian high-grade serous carcinoma. Ann Oncol 24 (Suppl 10):x16–21
Wiegand KC, Shah SP, Al-Agha OM et al (2010) ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med 363:1532–1543
Buttin BM, Herzog TJ, Powell MA et al (2002) Epithelial ovarian tumors of low malignant potential: the role of microinvasion. Obstet Gynecol 99:11
Tempfer CB, Polterauer S, Bentz EK et al (2007) Accuracy of intraoperative frozen section analysis in borderline tumors of the ovary: a retrospective analysis of 96 cases and review of the literature. Gynecol Oncol 107(2):248–252
Prat J, FIGO Committee on Gynecologic Oncology (2014) Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet 124(1):1–5
Seidman JD, Kurman RJ (2000) Ovarian serous borderline tumors: a critical review on the literature with emphasis on prognostic factors. Hum Pathol 31:529–557
Timmerman D, Testa AC, Bourne T et al (2008) Simple ultrasound-based rules for the diagnosis of ovarian cancer. Ultrasound Obstet Gynecol 31(6):681–690
Thomassin-Naggara I, Toussaint I, Perrot N et al (2011) Characterization of complex adnexal masses: value of adding perfusion- and diffusion-weighted MR imaging to conventional MR imaging. Radiology 258:793–803
International Federation of Gynaecology and Obstetrics (1989) Annual report and results of treatment in gynaecologic cancer. Int J Gynaecol Obstet 28:189–190
Ovarian Low Malignant Potential Tumors Treatment (PDQ®) (2013) http://www.cancer.gov/cancertopics/pdq/treatment/ovarian-low-malignantpotential/HealthProfessional/page1/AllPages
Ovarian Low Malignant Potential Tumors Treatment (PDQ®) (2013) http://www.cancer.gov/cancertopics/pdq/treatment/ovarian-low-malignant-potential/HealthProfessional/page1/AllPages
Morice P (2006) Borderline tumors of the ovary and fertility. Eur J Cancer 42:149–158
Tinelli R, Tinelli A, Tinelli FG et al (2006) Conservative surgery for borderline ovarian tumors: a review. Gynecol Oncol 100:185–191
Borgfeldt C, Iosif C, Masback A (2007) Fertility-sparing surgery and outcome in fertile women with ovarian borderline tumors and epithelial invasive ovarian cancer. Eur J Obstet Gynecol Reprod Biol 134:110–114
De Iaco P, Ferrero A, Rosati F et al (2009) Behaviour of ovarian tumors of low malignant potential treated with conservative surgery. Eur J Surg Oncol 35(6):643–648
Fauvet R, Boccara J, Dufournet C et al (2005) Laparoscopic management of borderline ovarian tumors: results of a French multicenter study. Ann Oncol 16:403–410
Poncelet C, Fauvet R, Boccara J et al (2006) Recurrence after cystectomy for borderline ovarian tumors: results of a French multicenter study. Ann Surg Oncol 13:565–571
Camatte S, Morice P, Rey A et al (2004) Impact of surgical staging in patients with macroscopic “stage I” ovarian borderline tumors: analysis of a continuous series of 101 cases. Eur J Cancer 40:1842–1849
Shih KK, Zhou QC, Aghajanian C et al (2011) Patterns of recurrence and role of adjuvant chemotherapy in stage II–IV serous ovarian borderline tumors. Gynecol Oncol 120:480–484
Lesieur B, Kane A, Duvillard P et al (2011) Prognostic value of lymph node involvement in ovarian serous borderline tumors. Am J Obstet Gynecol 204:438.e1–7
Kanat-Pektas M, Ozat M, Gungor T et al (2011) Complete lymph node dissection: is it essential for the treatment of borderline epithelial ovarian tumors? Arch Gynecol Obstet 283:879–884
Faluyi O, Mackean M, Gourley C et al (2010) Interventions for the treatment of borderline ovarian tumors. Cochrane Database Syst Rev (9):CD007696
Trimble CL, Kosary C, Trimble EL (2002) Long-term survival and patterns of care in women with ovarian carcinoma: a population-based analysis. Gynecol Oncol 86:34–37
Fauvet R, Demblocque E, Morice P et al (2012) Comparison of epidemiological factors between serous and mucinous borderline ovarian tumors: therapeutic implications. Bull Cancer 99:551–556
Palomba S, Zupi E, Russo T et al (2007) Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumors: a randomized controlled study. Hum Reprod 22:578–585
Fauvet R, Poncelet C, Boccara J et al (2005) Fertility after conservative treatment for borderline ovarian tumors: a French multicenter study. Fertil Steril 83:284–290, quiz 525–286
von Wolff M, Montag M, Dittrich R et al (2011) Fertility preservation in women—a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin’s lymphoma and borderline ovarian tumors by the fertility preservation network FertiPROTEKT. Arch Gynecol Obstet 284:427–435
Silva EG, Ghershenson DM, Malpica A et al (2006) The recurrence and the overall survival rates of ovarian serous borderline neoplasms with noninvasive implants is time dependent. Am J Surg Pathol 30:1367
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© 2015 International Society of Gynecological Endocrinology
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Sismondi, P., Daniele, A., Ferrero, A., Ravarino, N., Biglia, N. (2015). Low Malignant Potential Tumors. In: Fauser, B.C.J.M., Genazzani, A.R. (eds) Frontiers in Gynecological Endocrinology. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-319-09662-9_21
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DOI: https://doi.org/10.1007/978-3-319-09662-9_21
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