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A Point-of-Care Device for Immunosuppressants Monitoring in Transplanted Patients

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Sensors

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 319))

Abstract

In the hospital Intensive Care Units (ICU) there is an even greater demand by the physicians for the continuous immunosuppressant drug monitoring in the transplanted patient therapy, in order to avoid different risks and diseases which may occur as result of some drug dosage related effect, such the rejection crisis or sepsis. Here we present a novel design of a point of care testing (POCT) device for the drug dose—adjustment in this kind of patients. The working principle of the device will be discussed. Preliminary tests on the immunoassay strategies for immunosuppressant drugs recognition such as on the optical chip realization and characterization are reported.

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Acknowledgements

European Community for the funded STREP project NANODEM (NANOphotonic DEvice for Multiple therapeutic drug monitoring), under 7th framework programme (FP7-ICT-2011—contract 8318372), is gratefully acknowledged. The authors thank the group of Prof. G. Orellana (Universidad Complutense de Madrid, Spain) for the preparation of the tacrolimus derivative.

Author information

Authors and Affiliations

  1. Information Engineering and Mathematics Department, University of Siena, San Niccolò, Via Roma 56, 53100, Siena, Italy

    C. Berrettoni

  2. IFAC – CNR, “Nello Carrara” Institute of Applied Physics, Via Madonna del Piano 10, 50019, Sesto Fiorentino, FI, Italy

    C. Berrettoni, C. Trono, S. Tombelli, A. Giannetti, S. Berneschi & F. Baldini

  3. IREA – CNR, Institute for Electromagnetic Sensing of the Environment, Via Diocleziano 328, 80124, Napoli, Italy

    I. A. Grimaldi, G. Persichetti, G. Testa & R. Bernini

  4. Datamed Srl, Via Achille Grandi 4/6, 20068, Peschiera Borromeo, Italy

    G. Porro

  5. Microfluidic ChipShop GmbH, Stockholmer Str. 20, 07747, Jena, Germany

    C. Gärtner

Authors
  1. C. Berrettoni
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  2. C. Trono
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  3. S. Tombelli
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  4. A. Giannetti
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  5. S. Berneschi
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  6. F. Baldini
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  7. I. A. Grimaldi
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  8. G. Persichetti
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  9. G. Testa
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  10. R. Bernini
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  11. G. Porro
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  12. C. Gärtner
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Corresponding author

Correspondence to C. Berrettoni .

Editor information

Editors and Affiliations

  1. Faculty of Bioscience and Technologies for Food Agriculture and Environment, University of Teramo, Mosciano S.A., Teramo, Italy

    Dario Compagnone

  2. Institute of Applied Physics IFAC-CNR, Firenze, Italy

    Francesco Baldini

  3. Dept. of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy

    Corrado Di Natale

  4. University of Cassino, Cassino, Italy

    Giovanni Betta

  5. CNR, Head of Inst. of Microelectronics a, Lecce, Italy

    Pietro Siciliano

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© 2015 Springer International Publishing Switzerland

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Berrettoni, C. et al. (2015). A Point-of-Care Device for Immunosuppressants Monitoring in Transplanted Patients. In: Compagnone, D., Baldini, F., Di Natale, C., Betta, G., Siciliano, P. (eds) Sensors. Lecture Notes in Electrical Engineering, vol 319. Springer, Cham. https://doi.org/10.1007/978-3-319-09617-9_6

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  • DOI: https://doi.org/10.1007/978-3-319-09617-9_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09616-2

  • Online ISBN: 978-3-319-09617-9

  • eBook Packages: EngineeringEngineering (R0)

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