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Pharmacotherapy in Aortic Disease pp 213–238Cite as

Acute Aortic Syndrome: Medical Management

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Part of the book series: Current Cardiovascular Therapy ((CCT,volume 7))

Abstract

Both chronic and acute diseases of the aorta, including trauma, are attracting increasing attention both in the light of an ageing Western population and with the advent of modern diagnostic modalities and therapeutic options to manage aortic pathology. In the case of aortic ectasia the individual rate of expansion and the risk of rupture may be assessed from co-morbidities, hypertensive state, or connective tissue disease, and should be quantified regardless of anatomic location for timely selection and treatment. Acute aortic syndrome, a term comprising acute dissection, intramural haematoma, and penetrating aortic ulcers, may share common ground by the observation of microapoplexy of the aortic wall, eventually leading to higher wall stress, facilitating progressive dilatation, intramural haemorrhage, dissection, and eventually rupture; chronic hypertension and connective tissue disorders are likely to promote this mechanism.

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Author information

Authors and Affiliations

  1. Heart Center Rostock, University of Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany

    Christoph A. Nienaber MD, PhD

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  1. Christoph A. Nienaber MD, PhD
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Correspondence to Christoph A. Nienaber MD, PhD .

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Editors and Affiliations

  1. Imaging Cardiac Department Aortic Diseases Unit, Vall d’hebrón University Hospital, Barcelona, Spain

    Arturo Evangelista

  2. Heart Center Rostock, Rostock School of Medicine University Hospital Rostock, Rostock, Germany

    Christoph A. Nienaber

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Nienaber, C.A. (2015). Acute Aortic Syndrome: Medical Management. In: Evangelista, A., Nienaber, C. (eds) Pharmacotherapy in Aortic Disease. Current Cardiovascular Therapy, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-09555-4_5

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  • DOI: https://doi.org/10.1007/978-3-319-09555-4_5

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