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Abstract

The perineurium is composed of multiple concentric single-cell layers enclosing individual nerve fascicles. Each layer has a thickness equivalent to the width of a perineurial cell. Groups of these cells join by means of tight junctions and desmosomes to form layers that function as a barrier against diffusion of particles across them. Perineurial internal layers have more of these specialized unions among perineurial cells, which are proximal to nerve fascicles.

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References

  1. Reina MA, Arriazu R, Collier CB, Sala-Blanch X. Histology and electron microscopy of human peripheral nerves of clinical relevance to the practice of nerve blocks. Rev Esp Anestesiol Reanim. 2013;60:552–62.

    Article  CAS  PubMed  Google Scholar 

  2. Reina MA, De Andres JA, Hernández JM, Arriazu Navarro R, Durán Mateos EM, Prats-Galino A. Successive changes in extraneural structures from the subarachnoid nerve roots to the peripheral nerve, influencing anesthetic block, and treatment of acute postoperative pain. Eur J Pain Suppl. 2011;5:377–85.

    Article  Google Scholar 

  3. Reina MA. Contribute of electron microscopy in the regional anesthesia. Reg Anesth Pain Med Suppl. 2011;36:E81–5.

    Google Scholar 

  4. De Andrés JA, Reina MA, López A, Sala-Blanch X, Prats A. Blocs nerveux périphériques, paresthésies et injections intraneurales. Le Practicien En Anesth Réanim. 2010;14:213–21.

    Article  Google Scholar 

  5. Piña-Oviedo S, Ortiz-Hidalgo C. The normal and neoplastic perineurium: a review. Adv Anat Pathol. 2008;15:147–64.

    Article  PubMed  Google Scholar 

  6. Pummi KP, Heape AM, Grenman RA, Peltonen JT, Peltonen SA. Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium. J Histochem Cytochem. 2004;52:1037–46.

    Article  CAS  PubMed  Google Scholar 

  7. Olsson Y, Kristensson K. The perineurium as a diffusion barrier to protein tracers following trauma to nerves. Acta Neuropathol. 1973;23:105–11.

    Article  CAS  PubMed  Google Scholar 

  8. Soderfeldt B, Olsson Y, Kistensson K. The perineurium as a diffusion barrier to protein tracers in human peripheral nerve. Acta Neuropathol. 1973;25:120–6.

    Article  CAS  PubMed  Google Scholar 

  9. Reina MA, López A, De Andrés JA. The blood-nerve barrier in peripheral nerves. Rev Esp Anestesiol Reanim. 2003;50:80–6.

    CAS  PubMed  Google Scholar 

  10. Shinowara NL, Michel ME, Rapoport SI. Morphological correlates of permeability in the frog perineurium: vesicles and transcellular channels. Cell Tissue Res. 1982;227:11–22.

    Article  CAS  PubMed  Google Scholar 

  11. Reina MA, Wikinski J, Prats A, Machés F. Estructura del nervio periférico [in Spanish]. In: Wikinski J, Reina MA, Bollini C, et al., editors. Diagnóstico, prevensión y tratamiento de las complicaciones neurológicas asociadas con la anestesia regional periférica y central. Buenos Aires: Editorial Médica Panamericana; 2011. p. 71–86.

    Google Scholar 

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Reina, M.A., Colman Peyrano, E., Diamantopoulos, J., De Andrés, J.A. (2015). Ultrastructure of the Perineurium. In: Reina, M., De Andrés, J., Hadzic, A., Prats-Galino, A., Sala-Blanch, X., van Zundert, A. (eds) Atlas of Functional Anatomy for Regional Anesthesia and Pain Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-09522-6_4

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  • DOI: https://doi.org/10.1007/978-3-319-09522-6_4

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-09522-6

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