Abstract
To understand the cellular mechanisms of HCC, and to develop novel therapeutic options for HCC, a number of animal models have been developed over the years. These include rodent, rabbit, swine, and primate model systems. While these animal models have helped to understand HCC to some extent, an ideal model system that mimics the human condition in terms of physiology, etiology and clinical setting is still missing. Towards this goal, there is a greater need than ever to develop a novel animal model that will recapitulate the human condition in its entirety.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adam S, Rund LA, Kuzmuk KN, Zachary JF, Schook LB, Counter CM (2007) Genetic induction of tumorigenesis in swine. Oncogene 26:1038–1045
Aravalli RN, Golzarian J, Cressman EN (2009) Animal models of cancer in interventional radiology. Eur Radiol 19(5):1049–1053
Aterman K (1987) Localized hepatocarcinogenesis: the response of the liver and kidney to implanted carcinogens. J Cancer Res Clin Oncol 1:507–538
Beer S, Zetterberg A, Ihrie RA, McTaggart RA, Yang Q, Bradon N, Arvanitis C, Attardi LD, Feng S, Ruebner B, Cardiff RD, Felsher DW (2004) Developmental context determines latency of MYC-Induced tumorigenesis. PLoS Biol 2(11):1785–1798
Foster J (2005) Spontaneous and drug-induced hepatic pathology of the laboratory beagle dog, the cynomolgus macaque and the marmoset. Toxicol Pathol 33(1):63–74
Kulkarni K, Jacobson IM, Tennant BC (2007) The role of the Woodchuck model in the treatment of hepatitis B virus infection. Clin Liver Dis 11:707–725
Li X, Zheng C-S, Feng G-S, Zhao C-K, Zhao J-G, Liu X (2002) An implantable rat liver tumor model for experimental transarterial chemoembolization therapy and its imaging features. World J Gastroenterol 8(6):1035–1039
Li X, Zhou X, Guan Y, Wang Y-X J, Scutt D, Gong Q-Y (2006) N-Nitrosodiethylamine-induced pig liver hepatocellular carcinoma model: radiological and histopathological studies. Cardiovasc Intervent Radiol 29:420–428
Lim IK (2002) Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats. Mech Ageing Dev 123(12):1665–1680
Rous P, Beard JW (1934) A virus-induced mammalian growth with the characters of a tumor (the Shope Rabbit Papilloma): II Experimental alterations of the growth on the skin: morphological considerations: the phenomena of retrogression. J Exp Med 60(6):723–740
Tennant B, Toshkov IA, Peek SF, Jacob JR, Menne S, Hornbuckle WE, Schinazi RD, Korba BE, Cote PJ, Gerin JL (2004) Hepatocellular carcinoma in the Woodchuck model of hepatitis B virus infection. Gastroenterology 127:S283–S293
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2014 The Author(s)
About this chapter
Cite this chapter
Aravalli, R.N., Steer, C.J. (2014). Animal Models of Liver Cancer. In: Hepatocellular Carcinoma. SpringerBriefs in Cancer Research. Springer, Cham. https://doi.org/10.1007/978-3-319-09414-4_6
Download citation
DOI: https://doi.org/10.1007/978-3-319-09414-4_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-09413-7
Online ISBN: 978-3-319-09414-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)