Skip to main content
SpringerLink
Log in

Liver Metastases from Kidney Cancer

  • Chapter
  • First Online:
Noncolorectal, Nonneuroendocrine Liver Metastases

  • 935 Accesses

Abstract

Kidney cancer is the ninth most frequent cause of malignant tumors in developed countries. Liver metastases from kidney cancer are present in 20.3 % of metastatic kidney cancers. In patient with metastatic kidney cancer, staging is a fundamental step to determine both prognosis and therapeutical approach. Options for treatment of liver metastases from renal cancer include surgery, ablative therapies, and chemotherapy. Indications vary depending on the stage of the disease, presence of extrahepatic metastases, and general status of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin. 55(2):74–108

    Google Scholar 

  2. Mathew A, Devesa SS, Fraumeni JF, Chow WH (2002) Global increases in kidney cancer incidence, 1973–1992. Eur J Cancer Prev 11(2):171–178

    Article  CAS  PubMed  Google Scholar 

  3. Siegel R, Naishadham D, Jemal A (2012) Cancer statistic 2012. CA Cancer J Clin 61(1):10–29

    Article  Google Scholar 

  4. Bianchi M, Sun M, Jeldres C, Shariat SF, Trinh QD, Briganti A et al (2012) Distribution of metastatic sites in renal cell carcinoma: a population-based analysis. Annal Oncol 23(4):973–980

    Article  CAS  Google Scholar 

  5. Janzen NK, Kim HL, Figlin RA, Belldegrun AS (2013) Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am 30(4):843–852

    Article  Google Scholar 

  6. Vera-Badillo FE, Conde E, Duran I (2012) Chromophobe renal cell carcinoma: a review of an uncommon entity. Int J Urol 19(10):894–900

    Article  CAS  PubMed  Google Scholar 

  7. García-Donas J, Hernando S, Romero N, Jara C (2011) Knowledge of hereditary renal cancer syndromes: a pending issue for oncologists. Anticancer Drugs 22(Suppl 1):15–20

    Article  Google Scholar 

  8. Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM et al (2003) Von Hippel-Lindau disease. Lancet 361(9374):2059–2067

    Article  CAS  PubMed  Google Scholar 

  9. Toro JR, Wei MH, Glenn GM, Weinreich M, Toure O, Vocke C et al (2008) BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dube syndrome: a new series of 50 families and a review of published reports. J Med Genet 45(6):321–331

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Fowler JE (1987) Nephrectomy in metastatic renal cell carcinoma. Urol Clin N Am 14(4):749–756

    Google Scholar 

  11. Patel NP, Lavengood RW (1978) Renal cell carcinoma: natural history and results of treatment. J Urol 119(6):722–726

    CAS  PubMed  Google Scholar 

  12. Gotoh A, Kitazawa S, Mizuno Y, Takenaka A, Arakasawa S, Matsumoto O et al (1993) Common expression of parathyroid hormone-related protein and no correlation of calcium level in renal cell carcinomas. Cancer 71(9):2803–2806

    Article  CAS  PubMed  Google Scholar 

  13. Utz D, Warren M, Gregg J, Ludwig J, Kelais PP (1970) Reversible hepatic dysfunction associated with hypernephroma. Mayo Clin Proc 45(3):161–169

    CAS  PubMed  Google Scholar 

  14. Warshauer DM, McCarthy SM, Street L, Bookbinder MJ, Glickman MG, Richter J et al (1988) Detection of renal masses: sensitivities and specificities of excretory urography/linear tomography, US, and CT. Radiology 169(2):363–365

    Article  CAS  PubMed  Google Scholar 

  15. Jakimowicz JJ (2006) Intraoperative ultrasonography in open and laparoscopic abdominal surgery: an overview. Surg Endosc 20(Suppl 2):425–435

    Article  Google Scholar 

  16. Weyman PJ, McClennan BL, Stanley RJ, Levitt RG, Sagel SS (1980) Comparison of computed tomography and angiography in the evaluation of renal cell carcinoma. Radiology 137(2):417–424

    Article  CAS  PubMed  Google Scholar 

  17. Mignon F, Mesurolle B (2003) Local recurrence and metastatic dissemination of renal cell carcinoma: clinical and imaging characteristics. J Radiol 84(3):275–284

    CAS  PubMed  Google Scholar 

  18. Miyauchi I, Brown RS, Grossman HB, Wojno K, Wahl RL (1996) Correlation between visualization of primary renal cancer by FDG-PET and histopathological findings. J Nucl Med 37(Suppl):64

    Google Scholar 

  19. Kunkle DA, Crispen PL, Li T, Uzzo RG (2007) Metastatic renal cell carcinoma: implications for surveillance of small renal masses. J Urol 177(5):1692–1696

    Article  PubMed  Google Scholar 

  20. Thompson H, Hill J, Babayev Y, Cronin A, Kaag M, Kundu S et al (2009) Risk of metastatic renal cancer according to tumor size. J Urol 182(1):41–45

    Article  PubMed Central  PubMed  Google Scholar 

  21. Ritchie AWS, Chisholm GD (1983) The natural history of renal carcinoma. Semin Oncol 10:390–400

    CAS  PubMed  Google Scholar 

  22. Suppiah R, Shaheen PE, Elson P, Misbah SA, Wood L, Motzer RJ et al (2006) Thrombocytosis as a prognostic factor for survival in patients with metastatic renal cell carcinoma. Cancer 107:1793–1800

    Article  PubMed  Google Scholar 

  23. Hyder O, Pulitano C, Firoozmand A, Dodson R, Wolfgang CL, Choti MA et al (2013) A risk model to predict 90-day mortality among patients undergoing hepatic resection. J Am Coll Surg 216(6):1049–1056

    Article  PubMed Central  PubMed  Google Scholar 

  24. Sakaguchi S, Hishiki S, Nakamura S, Koyano K, Kosaka A (1992) Extension incision for renal carcinoma including invaded vena cava and right lobe of liver. Urology 39(3):285–288

    Article  CAS  PubMed  Google Scholar 

  25. Yezhelyev M, Master V, Egnatashvili V, Kooby D (2009) Combined nephrectomy and major hepatectomy: indications, outcomes, and recommendations. J Am Coll Surg 208(3):410–418

    Article  PubMed  Google Scholar 

  26. Talarico F, Buli P, Iusco D, Sangiorgi A, Jovine E (2007) Synchronous nephrectomy and right hepatectomy for metastatic chromophobe renal cell carcinoma: report of a case and review of the literature. Chir Ital 59(2):257–261

    PubMed  Google Scholar 

  27. Wong JA, Whelan T, Morse M (2006) Radical nephrectomy with en bloc resection of liver, diaphragm, and lung for locally invasive sarcomatoid renal cell carcinoma. Urology 68(4):890.e1–4

    Article  PubMed  Google Scholar 

  28. Flanigan RC, Mickisch G, Sylvester R, Tangen C, Van Poppel H, Crawford ED (2004) Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol 171(3):1071–1076

    Article  PubMed  Google Scholar 

  29. Mickisch GH, Garin A, van Poppel H, de Prijck L, Sylvester R (2001) Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet 358(9286):966–970

    Article  CAS  PubMed  Google Scholar 

  30. Uzo RG, Novick AC (2001) Nephron-saving surgery for renal tumors: indications, techniques and outcomes. J Urol 166(1):6–18

    Article  Google Scholar 

  31. Shuch B, Lam JS, Belldegrun AS (2006) Open partial nephrectomy for the treatment of renal cell carcinoma. Curr Urol Rep 7(1):31–38

    Article  PubMed  Google Scholar 

  32. Kranebeck AE, Liebovich BC, Lohse CM, Kwon ED, Zincke H, Blute ML (2006) The role of NSS in metastatic renal cell carcinoma. J Urol 176:1990–1995

    Article  Google Scholar 

  33. Kłącz J, Matuszewski M, Michajłowski J, Zachalski W, Markuszewski M, Krajka K (2013) There is no place for targeted therapy neoadjuvant treatment in Polish Health System – an analysis of radical nephrectomies in patients with large kidney tumors. Cent Eur J Urol 66(1):31–35

    Google Scholar 

  34. Thelen A, Jonas S, Benckert C, Lopez E, Rudolph B, Neumann U et al (2007) Liver resection for metastases from renal cell carcinoma. World J Surg 31(4):802–807

    Article  PubMed  Google Scholar 

  35. Hofmann HS, Neef H, Krohe K, Andreev P, Silber RE (2005) Prognostic factors and survival after pulmonary resection of metastatic renal cell carcinoma. Eur Urol 48(1):77–81

    Article  PubMed  Google Scholar 

  36. Ruys AT, Tanis PJ, Iris ND, van Duijvendijk P, Verhoef C, Porte RJ et al (2011) Surgical treatment of renal cell cancer liver metastases: a population-based study. Ann Surg Oncol 18(7):1932–1938

    Article  PubMed Central  PubMed  Google Scholar 

  37. Hatzaras I, Gleisner AL, Pulitano C, Sandroussi C, Hirose K, Hyder O et al (2012) A multi-institution analysis of outcomes of liver-directed surgery for metastatic renal cell cancer. HPB (Oxford) 14(8):532–538

    Article  Google Scholar 

  38. Aloia TA, Adam R, Azoulay D, Bismuth H, Catastaing D (2006) Outcome following hepatic resection of metastatic renal tumors: the Paul Brousse Hospital experience. HPB (Oxford) 8(2):100–105

    Article  PubMed Central  Google Scholar 

  39. Yun BL, Lee JM, Baek JH, Kim SH, Le JY, Han JK et al (2011) Radiofrequency ablation for treating liver metastases from a non-colorectal origin. Korean J Radiol 12(5):579–587

    Article  PubMed Central  PubMed  Google Scholar 

  40. Sorensen SM, Mortensen FV, Nielsen DT (2007) Radiofrequency ablation of colorectal liver metastases: long-term survival. Acta Radiol 48(3):253–258

    Article  CAS  PubMed  Google Scholar 

  41. Nabil M, Gruber T, Yakoub D, Ackermann H, Zangos S, Vogl TJ (2008) Repetitive transarterial chemoembolization (TACE) of liver metastases from renal cell carcinoma: local control and survival results. Eur Radiol 18(7):1456–1463

    Article  PubMed  Google Scholar 

  42. Brugarolas J (2007) Renal-cell carcinoma–molecular pathways and therapies. N Engl J Med 356(2):185–187

    Article  CAS  PubMed  Google Scholar 

  43. Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H et al (2004) Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64(19):7099–7109

    Article  CAS  PubMed  Google Scholar 

  44. Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S et al (2008). Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372(9637):449–456

    Google Scholar 

  45. Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalin SL et al (2003) A randomized trial of bevacizumab, an antivascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349(5):427–434

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  46. Witteles RM, Telli ML, Fisher GA, Srinivas S (2008) Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. J Clin Oncol 19(9):1613–1618

    Google Scholar 

  47. Shinohara N, Takahashi M, Kamishima T, Ikushima H, Otsuka N, Ishizu A et al (2011) The incidence and mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma. Br J Cancer 104(2):241–247

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hepatobiliary Surgery Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, MI, 20132, Italy

    Enrico Pinotti, Francesca Ratti, Federica Cipriani & Luca Aldrighetti

Authors
  1. Enrico Pinotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesca Ratti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Federica Cipriani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Luca Aldrighetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Luca Aldrighetti .

Editor information

Editors and Affiliations

  1. Department of Surgical Sciences Organ Transplantation and Advanced Technologies, University of Catania, Cannizzaro Hospital, Catania, Catania, Italy

    Isidoro Di Carlo

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Pinotti, E., Ratti, F., Cipriani, F., Aldrighetti, L. (2015). Liver Metastases from Kidney Cancer. In: Di Carlo, I. (eds) Noncolorectal, Nonneuroendocrine Liver Metastases. Springer, Cham. https://doi.org/10.1007/978-3-319-09293-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-09293-5_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09292-8

  • Online ISBN: 978-3-319-09293-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation