Abstract
Calcific aortic valve disease (CAVD) is still an unsolved medical problem, because the pathogenesis of CAVD is poorly understood and early calcification is hard to identify. The lack of high-resolution imaging tools to study early stage disease further hampers the search for therapeutic targets.
Micro-optical coherence tomography (μOCT), which is a new form of OCT, is the highest-resolution cross-sectional OCT technology available today with 1 μm resolution. We used μOCT to visualize detailed cellular and subcellular structure associated with early calcific changes in diseased human and murine aortic valves. The results suggest that μOCT imaging has the potential to provide new insights into underlying mechanisms of CAVD.
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Acknowledgment
This work was funded in part by NIH R01HL076398 and R01HL114805 (to EA).
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Drs. Tearney, Gardecki, Liu, and Chu have applied for patents on the μOCT technology. Dr. Tearney is a consultant for and receives sponsored research funding from Samsung Advanced Institute of Technology.
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Nomura, Y. et al. (2015). Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease. In: Aikawa, E. (eds) Cardiovascular Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-09268-3_12
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DOI: https://doi.org/10.1007/978-3-319-09268-3_12
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