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Pathophysiology and Epidemiology of Stress Fractures

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Abstract

Stress injury of bone includes a spectrum from hyperactive bone remodeling to a discrete fracture line visible on imaging. Stress fractures can occur when bone, either healthy or osteopenic, is subject to repeated loading with a subsequent loss of normal bone metabolism and failure of remodeling. Factors that increase load, such as repetitive impact through competition or training for sports or the military, contribute to the development of a stress fracture. They are also more common in the lower extremity, which sees loads that are multiples of body weight during many activities. Similarly, factors that affect normal bone turnover such as metabolic abnormalities, nutrient deficiencies and even genetic predisposition also contribute to the risk of developing a stress fracture. The incidence of stress fractures is difficult to establish from the current literature due to a variation in the quality and method of exposure reporting between studies and the heterogeneity of stress injury by location. Data on the occurrences and incidence rate of stress fracture do suggest, however, that females, runners, and military personnel have the highest incidence rates.

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References

  1. Kaplan FS, Hayes WC, Keaveny TM, Boskey A, Einhorn TA, Iannotti JP. Form and function of bone. In: Simon SR, editor. Orthopaedic basic science. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1994.

    Google Scholar 

  2. Nalla RK, Kinney JH, Ritchie RO. Letters: mechanistic fracture criteria for the failure of human cortical bone. Nat Mater. 2003;2:164–8.

    Article  PubMed  CAS  Google Scholar 

  3. Iundusi R, Scialdoni A, Arduini M, Battisti D, Piperno A, Gasbarra E, et al. Stress fractures in the elderly: different pathogenetic features compared with young patients. Aging Clin Exp Res. 2013;25(1):89–91.

    Article  Google Scholar 

  4. Haris PA, Schache AG, Crossley KM, Wrigley TV, Creaby MW. Sagittal plane bending moments acting on the lower leg during running. Gait Posture. 2010;31(2):218–22.

    Article  Google Scholar 

  5. Sasimontonkul S, Bay BK, Pavol MJ. Bone contact forces on the distal tibia during the stance phase of running. J Biomech. 2007;40(15):3503–9.

    Article  PubMed  Google Scholar 

  6. Schnackenburg KE, Macdonald HM, Ferber R, Wiley JP, Boyd SK. Bone quality and muscle strength in female athletes with lower limb stress fractures. Med Sci Sports Exerc. 2011;43(11):2110–9.

    Article  PubMed  Google Scholar 

  7. Stanitski CL, McMaster JH, Scranton PE. On the nature of stress fractures. Am J Sports Med. 1978;6(6):391–6.

    Article  PubMed  CAS  Google Scholar 

  8. Piekarski K, Munroe M. Transport mechanism operating between blood supply and osteocytes in long bones. Nature. 1977;269:80–2.

    Article  PubMed  CAS  Google Scholar 

  9. Otter MW, Qin YX, Rubin CT, McLeod KJ. Does bone perfusion/reperfusion initiate bone remodeling and the stress fracture syndrome? Med Hypotheses. 1999;53:363–8.

    Article  PubMed  CAS  Google Scholar 

  10. Simpson PJ, Lucchesi BR. Free radicals and myocardial ischemia and reperfusion. J Lab Clin Med. 1987;110:13–30.

    PubMed  CAS  Google Scholar 

  11. Romani WA, Gieck JH, Perrin DH, Saliba EN, Kahler DM. Mechanisms and management of stress fractures in physically active persons. J Athl Train. 2002;37(3):306–14.

    PubMed  PubMed Central  Google Scholar 

  12. McCormick F, Nwachukwu BU, Provencher MT. Stress fractures in runners. Clin Sports Med. 2012;31:291–306.

    Article  PubMed  Google Scholar 

  13. Goldberg B, Pecora P. Stress fractures: a risk of increased training in freshman. Phys Sportsmed. 1994;22:68–78.

    Google Scholar 

  14. Loud KJ, Micheli LJ, Bristol S, Austin SB, Gordon CM. Family history predicts stress fracture in active female adolescents. Pediatrics. 2007;120(2):e364–72. PubMed PMID: 17636110.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bennell KL, Malcolm SA, Thomas SA, Reid SJ, Brukner PD, Ebeling PR, et al. Risk factors for stress fractures in track and field athletes: a twelve-month prospective study. Am J Sports Med. 1996;24(6):810–8.

    Article  PubMed  CAS  Google Scholar 

  16. Cosman F, Ruffing J, Zion M, Uhorchak J, Ralston S, Tendy S, et al. Determinants of stress fracture risk in United States Military Academy cadets. Bone. 2013;55(2):359–66. PMID 23624291.

    Article  PubMed  Google Scholar 

  17. Vaitkevicius H, Witt R, Maasdam M, Walters K, Gould M, Mackenzie S, et al. Ethnic differences in titratable acid excretion and bone mineralization. Med Sci Sports Exerc. 2002;34(2):295–302.

    Article  PubMed  CAS  Google Scholar 

  18. Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K. Calcium and vitamin D supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res. 2008;23:741–9.

    Article  PubMed  CAS  Google Scholar 

  19. Myburgh KH, Hutchins J, Fataar AB, Hough SF, Noakes TD. Low bone density is an etiologic factor for stress fractures in athletes. Ann Intern Med. 1990;113(10):754–9.

    Article  PubMed  CAS  Google Scholar 

  20. Bennell K, Matheson G, Meeuwisse W, Brukner P. Risk factors for stress fractures. Sports Med. 1999;28(2):91–122.

    Article  PubMed  CAS  Google Scholar 

  21. Merkel D, Moran DS, Yanovich R, Evans RK, Finestone AS, Constantini N, et al. The association between hematological and inflammatory factors and stress fractures among female military recruits. Med Sci Sports Exerc. 2008;40(11 Suppl):S691–7. PMID 18849864.

    Article  PubMed  Google Scholar 

  22. Stager JM, Hatler LK. Menarche in athletes: the influence of genetics and prepubertal training. Med Sci Sports Exerc. 1988;20(4):369–73.

    Article  PubMed  CAS  Google Scholar 

  23. Frost HM. A new direction for osteoporosis research: a review and proposal. Bone. 1991;12(6):56–72.

    Article  Google Scholar 

  24. Shaffer RA, Rauh MJ, Brodine SK, Trone DW, Macera CA. Predictors of stress fracture susceptibility in young female recruits. Am J Sports Med. 2006;34(1):108–15. PMID 16170040.

    Article  PubMed  Google Scholar 

  25. Rauh MJ, Macera CA, Trone DW, Shaffer RA, Brodine SK. Epidemiology of stress fracture and lower-extremity overuse injury in female recruits. Med Sci Sports Exerc. 2006;38(9):1571–7. PMID: 16960517.

    Article  PubMed  Google Scholar 

  26. Winfield AC, Moore J, Bracker M, Johnson CW. Risk factors associated with stress reactions in female marines. Mil Med. 1997;162(10):698–702.

    PubMed  CAS  Google Scholar 

  27. Sormaala MJ, Niva MH, Kiuru MJ, Mattila VM, Pihlajamäki HK. Stress injuries of the calcaneus detected with magnetic resonance imaging in military recruits. J Bone Joint Surg Am. 2006;88(10):2237–42. PMID 17015602.

    Article  PubMed  Google Scholar 

  28. Knapik J, Montain SJ, McGraw S, Grier T, Ely M, Jones BH. Stress fracture risk factors in basic combat training. Int J Sports Med. 2012;33(11):940–6. PMID 22821178.

    Article  PubMed  CAS  Google Scholar 

  29. Lee D, Armed Forces Health Surveillance Center (AFHSC). Stress fractures, active component, U.S. Armed Forces, 2004–2010. MSMR. 2011;18(5):8–11. PMID 21793616.

    PubMed  Google Scholar 

  30. Mattila VM, Niva M, Kiuru M, Pihlajamäki H. Risk factors for bone stress injuries: a follow-up study of 102,515 person-years. Med Sci Sports Exerc. 2007;39(7):1061–6. PMID 17596772.

    Article  PubMed  Google Scholar 

  31. Gam A, Goldstein L, Karmon Y, Mintser I, Grotto I, Guri A, et al. Comparison of stress fractures of male and female recruits during basic training in the Israeli anti-aircraft forces. Mil Med. 2005;170(8):710–2. PMID 16173215.

    PubMed  Google Scholar 

  32. Brunet ME, Cook SD, Brinker MR, Dickinson JA. A survey of running injuries in 1505 competitive and recreational runners. J Sports Med Phys Fitness. 1990;30(3):307–15.

    PubMed  CAS  Google Scholar 

  33. Tenforde AS, Sayres LC, McCurdy ML, Sainani KL, Fredericson M. Identifying sex-specific risk factors for stress fractures in adolescent runners. Med Sci Sports Exerc. 2013;45(10):1843–51. PMID 23584402.

    Article  PubMed  CAS  Google Scholar 

  34. Yagi S, Muneta T, Sekiya I. Incidence and risk factors for medial tibial stress syndrome and tibial stress fracture in high school runners. Knee Surg Sports Traumatol Arthrosc. 2013;21(3):556–63. PMID 22875369.

    Article  PubMed  Google Scholar 

  35. Abrams GD, Renstrom PA, Safran MR. Epidemiology of musculoskeletal injury in the tennis player. Br J Sports Med. 2012;46(7):492–8. PMID 22554841.

    Article  PubMed  Google Scholar 

  36. Balius R, Pedret C, Estruch A, Hernández G, Ruiz-Cotorro A, Mota J. Stress fractures of the metacarpal bones in adolescent tennis players: a case series. Am J Sports Med. 2010;38:1215–20.

    Article  PubMed  Google Scholar 

  37. Maquirriain J, Ghisi JP. The incidence and distribution of stress fractures in elite tennis players. Br J Sports Med. 2006;40(5):454–9. PMID 16632579.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  38. Field AE, Gordon CM, Pierce LM, Ramappa A, Kocher MS. Prospective study of physical activity and risk of developing a stress fracture among preadolescent and adolescent girls. Arch Pediatr Adolesc Med. 2011;165(8):723–8. PMID 21464375.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Niemeyer P, Weinberg A, Schmitt H, Kreuz PC, Ewerbeck V, Kasten P. Stress fractures in adolescent competitive athletes with open physis. Knee Surg Sports Traumatol Arthrosc. 2006;14(8):771–7. PubMed PMID: 16328465.

    Article  PubMed  Google Scholar 

  40. Pearce CJ, Brooks JH, Kemp SP, Calder JD. The epidemiology of foot injuries in professional rugby union players. Foot Ankle Surg. 2011;17(3):113–8. PubMed PMID: 21783068.

    Article  PubMed  Google Scholar 

  41. Ekstrand J, Torstveit MK. Stress fractures in elite male football players. Scand J Med Sci Sports. 2012;22(3):341–6. PubMed PMID: 20807388.

    Article  PubMed  CAS  Google Scholar 

  42. McCarthy MM, Voos JE, Nguyen JT, Callahan L, Hannafin JA. Injury profile in elite female basketball athletes at the Women’s National Basketball Association combine. Am J Sports Med. 2013;41(3):645–51. PubMed PMID: 23378506.

    Article  PubMed  Google Scholar 

  43. Frost WL, Chalmers DJ. Injury in elite New Zealand cricketers 2002-2008: descriptive epidemiology. Br J Sports Med. 2014;48:1002–7. PubMed PMID: 22942169.

    Article  PubMed  Google Scholar 

  44. Ekegren CL, Quested R, Brodrick A. Injuries in pre-professional ballet dancers: incidence, characteristics and consequences. J Sci Med Sport. 2014;17:271–5. PubMed PMID: 23988783.

    Article  PubMed  Google Scholar 

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Correspondence to Kurt P. Spindler MD .

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Wasserstein, D., Spindler, K.P. (2015). Pathophysiology and Epidemiology of Stress Fractures. In: Miller, T., Kaeding, C. (eds) Stress Fractures in Athletes. Springer, Cham. https://doi.org/10.1007/978-3-319-09238-6_1

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  • DOI: https://doi.org/10.1007/978-3-319-09238-6_1

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-09238-6

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