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Advances and Technical Standards in Neurosurgery pp 123–146Cite as

Optic Pathway Gliomas

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Part of the book series: Advances and Technical Standards in Neurosurgery ((NEUROSURGERY,volume 42))

Abstract

Optic pathway gliomas (OPGs) are among the most challenging neoplasms in modern pediatric neuro-oncology. Recent technological advances in imaging, surgery, and chemotherapy may lead to better understanding of the pathophysiology and better clinical results. This chapter reviews these advances and the current treatment paradigms.

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References

  1. Ahn Y, Cho BK et al (2006) Optic pathway glioma: outcome and prognostic factors in a surgical series. Childs Nerv Syst 22(9):1136–1142

    Article  PubMed  Google Scholar 

  2. Allen JC (2000) Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1. Pediatr Neurosurg 32(3):154–162

    Article  CAS  PubMed  Google Scholar 

  3. Amatya VJ, Akazawa R et al (2009) Clinicopathological and immunohistochemical features of three pilomyxoid astrocytomas: comparative study with 11 pilocytic astrocytomas. Pathol Int 59(2):80–85

    Article  PubMed  Google Scholar 

  4. Aquino VM, Fort DW et al (1999) Carboplatin for the treatment of children with newly diagnosed optic chiasm gliomas: a phase II study. J Neurooncol 41(3):255–259

    Article  CAS  PubMed  Google Scholar 

  5. Arkhangelsky VN (1966) Neoplasms of the optic nerve. Ophthalmologica 151(2):260–271

    Article  CAS  PubMed  Google Scholar 

  6. Assaf Y, Ben-Sira L et al (2006) Diffusion tensor imaging in hydrocephalus: initial experience. AJNR Am J Neuroradiol 27(8):1717–1724

    CAS  PubMed  Google Scholar 

  7. Astrup J (2003) Natural history and clinical management of optic pathway glioma. Br J Neurosurg 17(4):327–335

    Article  CAS  PubMed  Google Scholar 

  8. Avery RA, Bouffet E et al (2013) Feasibility and comparison of visual acuity testing methods in children with neurofibromatosis type 1 and/or optic pathway gliomas. Invest Ophthalmol Vis Sci 54(2):1034–1038

    Article  PubMed  Google Scholar 

  9. Avery RA, Ferner RE et al (2012) Visual acuity in children with low grade gliomas of the visual pathway: implications for patient care and clinical research. J Neurooncol 110(1):1–7

    Article  PubMed  Google Scholar 

  10. Avery RA, Liu GT et al (2011) Retinal nerve fiber layer thickness in children with optic pathway gliomas. Am J Ophthalmol 151(3):542–549.e542

    Article  PubMed Central  PubMed  Google Scholar 

  11. Awdeh RM, Kiehna EN et al (2012) Visual outcomes in pediatric optic pathway glioma after conformal radiation therapy. Int J Radiat Oncol Biol Phys 84(1):46–51

    Article  PubMed Central  PubMed  Google Scholar 

  12. Beyer RA, Paden P et al (1986) Moyamoya pattern of vascular occlusion after radiotherapy for glioma of the optic chiasm. Neurology 36(9):1173–1178

    Article  CAS  PubMed  Google Scholar 

  13. Binning MJ, Liu JK et al (2007) Optic pathway gliomas: a review. Neurosurg Focus 23(5):E2

    Article  PubMed  Google Scholar 

  14. Campagna M, Opocher E et al (2010) Optic pathway glioma: long-term visual outcome in children without neurofibromatosis type-1. Pediatr Blood Cancer 55(6):1083–1088

    Article  PubMed  Google Scholar 

  15. Cappelli C, Grill J et al (1998) Long-term follow up of 69 patients treated for optic pathway tumours before the chemotherapy era. Arch Dis Child 79(4):334–338

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Carpentieri SC, Waber DP et al (2003) Neuropsychological functioning after surgery in children treated for brain tumor. Neurosurgery 52(6):1348–1356; discussion 1356–1357

    Article  PubMed  Google Scholar 

  17. Chang L, El-Dairi MA et al (2010) Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas. J AAPOS 14(6):511–517

    Article  PubMed  Google Scholar 

  18. Chateil JF, Soussotte C et al (2001) MRI and clinical differences between optic pathway tumours in children with and without neurofibromatosis. Br J Radiol 74(877):24–31

    Article  CAS  PubMed  Google Scholar 

  19. Cnossen MH, Stam EN et al (1997) Endocrinologic disorders and optic pathway gliomas in children with neurofibromatosis type 1. Pediatrics 100(4):667–670

    Article  CAS  PubMed  Google Scholar 

  20. Combs SE, Schulz-Ertner D et al (2005) Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcome. Int J Radiat Oncol Biol Phys 62(3):814–819

    Article  PubMed  Google Scholar 

  21. Constantini S, Mohanty A et al (2013) Safety and diagnostic accuracy of neuroendoscopic biopsies: an international multicenter study. J Neurosurg Pediatr 11(6):704–709

    Article  PubMed  Google Scholar 

  22. Constantini S, Sgouros S et al (2013) Neuroendoscopy in the youngest age group. World Neurosurg 79(2 Suppl):S23.e21–S23.e11

    Google Scholar 

  23. Dalla Via P, Opocher E et al (2007) Visual outcome of a cohort of children with neurofibromatosis type 1 and optic pathway glioma followed by a pediatric neuro-oncology program. Neuro Oncol 9(4):430–437

    Article  PubMed  Google Scholar 

  24. Debus J, Kocagoncu KO et al (1999) Fractionated stereotactic radiotherapy (FSRT) for optic glioma. Int J Radiat Oncol Biol Phys 44(2):243–248

    Article  CAS  PubMed  Google Scholar 

  25. Dirks PB, Jay V et al (1994) Development of anaplastic changes in low-grade astrocytomas of childhood. Neurosurgery 34(1):68–78

    Article  CAS  PubMed  Google Scholar 

  26. Dodge HW Jr, Love JG et al (1958) Gliomas of the optic nerves. AMA Arch Neurol Psychiatr 79(6):607–621

    Article  Google Scholar 

  27. Erkal HS, Serin M et al (1997) Management of optic pathway and chiasmatic-hypothalamic gliomas in children with radiation therapy. Radiother Oncol 45(1):11–15

    Article  CAS  PubMed  Google Scholar 

  28. Fernandez C, Figarella-Branger D et al (2003) Pilocytic astrocytomas in children: prognostic factors – a retrospective study of 80 cases. Neurosurgery 53(3):544–553; discussion 554–555

    Article  PubMed  Google Scholar 

  29. Filippi CG, Bos A et al (2012) Magnetic resonance diffusion tensor imaging (MRDTI) of the optic nerve and optic radiations at 3 T in children with neurofibromatosis type I (NF-1). Pediatr Radiol 42(2):168–174

    Article  PubMed  Google Scholar 

  30. Fisher BJ, Leighton CC et al (2001) Results of a policy of surveillance alone after surgical management of pediatric low grade gliomas. Int J Radiat Oncol Biol Phys 51(3):704–710

    Article  CAS  PubMed  Google Scholar 

  31. Fisher MJ, Loguidice M et al (2012) Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis. Neuro Oncol 14(6):790–797

    Article  PubMed Central  PubMed  Google Scholar 

  32. Fouladi M, Wallace D et al (2003) Survival and functional outcome of children with hypothalamic/chiasmatic tumors. Cancer 97(4):1084–1092

    Article  PubMed  Google Scholar 

  33. Gajjar A, Bhargava R et al (1995) Low-grade astrocytoma with neuraxis dissemination at diagnosis. J Neurosurg 83(1):67–71

    Article  CAS  PubMed  Google Scholar 

  34. Gayre GS, Scott IU et al (2001) Long-term visual outcome in patients with anterior visual pathway gliomas. J Neuroophthalmol 21(1):1–7

    Article  CAS  PubMed  Google Scholar 

  35. Gil Z, Beni-Adani L et al (2001) Ascites following ventriculoperitoneal shunting in children with chiasmatic-hypothalamic glioma. Childs Nerv Syst 17(7):395–398

    Article  CAS  PubMed  Google Scholar 

  36. Goodden J, Thorpe N et al (2010) The role of surgery in optic pathway and chiasmatic-hypothalamic glioma’s in children – the alder hey experience. Childs Nerv Syst 26:545–592

    Article  Google Scholar 

  37. Grabenbauer GG, Schuchardt U et al (2000) Radiation therapy of optico-hypothalamic gliomas (OHG) – radiographic response, vision and late toxicity. Radiother Oncol 54(3):239–245

    Article  CAS  PubMed  Google Scholar 

  38. Grill J, Laithier V et al (2000) When do children with optic pathway tumours need treatment? An oncological perspective in 106 patients treated in a single centre. Eur J Pediatr 159(9):692–696

    Article  CAS  PubMed  Google Scholar 

  39. Gropman AL, Packer RJ et al (1998) Treatment of diencephalic syndrome with chemotherapy: growth, tumor response, and long term control. Cancer 83(1):166–172

    Article  CAS  PubMed  Google Scholar 

  40. Gururangan S, Fisher MJ et al (2007) Temozolomide in children with progressive low-grade glioma. Neuro Oncol 9(2):161–168

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  41. Hawkins C, Walker E et al (2011) BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma. Clin Cancer Res 17(14):4790–4798

    Article  CAS  PubMed  Google Scholar 

  42. Hernaiz Driever P, von Hornstein S et al (2010) Natural history and management of low-grade glioma in NF-1 children. J Neurooncol 100(2):199–207

    Article  PubMed  Google Scholar 

  43. Hoffman HJ, Humphreys RP et al (1993) Optic pathway/hypothalamic gliomas: a dilemma in management. Pediatr Neurosurg 19(4):186–195

    Article  CAS  PubMed  Google Scholar 

  44. Hollander MD, FitzPatrick M et al (1999) Optic gliomas. Radiol Clin North Am 37(1):59–71, ix

    Article  CAS  PubMed  Google Scholar 

  45. Hoyt WF, Baghdassarian SA (1969) Optic glioma of childhood. Natural history and rationale for conservative management. Br J Ophthalmol 53(12):793–798

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  46. Hug EB, Muenter MW et al (2002) Conformal proton radiation therapy for pediatric low-grade astrocytomas. Strahlenther Onkol 178(1):10–17

    Article  PubMed  Google Scholar 

  47. Jahraus CD, Tarbell NJ (2006) Optic pathway gliomas. Pediatr Blood Cancer 46(5):586–596

    Article  PubMed  Google Scholar 

  48. Janss AJ, Grundy R et al (1995) Optic pathway and hypothalamic/chiasmatic gliomas in children younger than age 5 years with a 6-year follow-up. Cancer 75(4):1051–1059

    Article  CAS  PubMed  Google Scholar 

  49. Jenkin D, Angyalfi S et al (1993) Optic glioma in children: surveillance, resection, or irradiation? Int J Radiat Oncol Biol Phys 25(2):215–225

    Article  CAS  PubMed  Google Scholar 

  50. Jost SC, Ackerman JW et al (2008) Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma. Pediatr Radiol 38(12):1293–1299

    Article  PubMed  Google Scholar 

  51. Kestle JR, Hoffman HJ et al (1993) Moyamoya phenomenon after radiation for optic glioma. J Neurosurg 79(1):32–35

    Article  CAS  PubMed  Google Scholar 

  52. Komotar RJ, Burger PC et al (2004) Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas. Neurosurgery 54(1):72–79; discussion 79–80

    Article  PubMed  Google Scholar 

  53. Kortmann RD, Timmermann B et al (2003) Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part I: Treatment modalities of radiation therapy. Strahlenther Onkol 179(8):509–520

    Article  PubMed  Google Scholar 

  54. Kortmann RD, Timmermann B et al (2003) Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part II: treatment-related late toxicity. Strahlenther Onkol 179(9):585–597

    Article  PubMed  Google Scholar 

  55. Kovalic JJ, Grigsby PW et al (1990) Radiation therapy for gliomas of the optic nerve and chiasm. Int J Radiat Oncol Biol Phys 18(4):927–932

    Article  CAS  PubMed  Google Scholar 

  56. Kwon Y, Bae JS et al (2005) Visual changes after gamma knife surgery for optic nerve tumors. Report of three cases. J Neurosurg 102 Suppl:143–146

    Article  PubMed  Google Scholar 

  57. Lacaze E, Kieffer V et al (2003) Neuropsychological outcome in children with optic pathway tumours when first-line treatment is chemotherapy. Br J Cancer 89(11):2038–2044

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  58. Lafay-Cousin L, Holm S et al (2005) Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction. Cancer 103(12):2636–2642

    Article  CAS  PubMed  Google Scholar 

  59. Lee AG (2007) Neuroophthalmological management of optic pathway gliomas. Neurosurg Focus 23(5):E1

    Article  PubMed  Google Scholar 

  60. Leonard JR, Perry A et al (2006) The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1. Neurology 67(8):1509–1512

    Article  CAS  PubMed  Google Scholar 

  61. Listernick R, Ferner RE et al (2007) Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations. Ann Neurol 61(3):189–198

    Article  CAS  PubMed  Google Scholar 

  62. Lober RM, Guzman R et al (2012) Application of diffusion tensor tractography in pediatric optic pathway glioma. J Neurosurg Pediatr 10(4):273–280

    Article  PubMed  Google Scholar 

  63. Massimi L, Tufo T et al (2007) Management of optic-hypothalamic gliomas in children: still a challenging problem. Expert Rev Anticancer Ther 7(11):1591–1610

    Article  PubMed  Google Scholar 

  64. McClatchey AI (2007) Neurofibromatosis. Annu Rev Pathol 2:191–216

    Article  CAS  PubMed  Google Scholar 

  65. McCullough DC, Epstein F (1985) Optic pathway tumors. A review with proposals for clinical staging. Cancer 56(7 Suppl):1789–1791

    Article  CAS  PubMed  Google Scholar 

  66. Merchant TE, Hua CH et al (2008) Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function. Pediatr Blood Cancer 51(1):110–117

    Article  PubMed  Google Scholar 

  67. Moreno L, Bautista F et al (2010) Does chemotherapy affect the visual outcome in children with optic pathway glioma? A systematic review of the evidence. Eur J Cancer 46(12):2253–2259

    Article  PubMed  Google Scholar 

  68. Nicolin G, Parkin P et al (2009) Natural history and outcome of optic pathway gliomas in children. Pediatr Blood Cancer 53(7):1231–1237

    Article  PubMed  Google Scholar 

  69. Opocher E, Kremer LC et al (2006) Prognostic factors for progression of childhood optic pathway glioma: a systematic review. Eur J Cancer 42(12):1807–1816

    Article  PubMed  Google Scholar 

  70. Packer R, Yalon M et al (2010) Phase I/II study of tarceva/rapamycin for recurrent pediatric low-grade gliomas (LGG). Neuro Oncol 12(6):ii20

    Google Scholar 

  71. Packer RJ, Ater J et al (1997) Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 86(5):747–754

    Article  CAS  PubMed  Google Scholar 

  72. Packer RJ, Jakacki R et al (2009) Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan. Pediatr Blood Cancer 52(7):791–795

    Article  PubMed  Google Scholar 

  73. Packer RJ, Lange B et al (1993) Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood. J Clin Oncol 11(5):850–856

    CAS  PubMed  Google Scholar 

  74. Parreno MG, Bo X et al (2011) Frameless stereotactic procedures in pediatric patients: safety and diagnostic efficacy. Childs Nerv Syst 27(12):2137–2140

    Article  PubMed  Google Scholar 

  75. Paz N, Levanon EY et al (2007) Altered adenosine-to-inosine RNA editing in human cancer. Genome Res 17(11):1586–1595

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  76. Peyster RG, Hoover ED et al (1983) High-resolution CT of lesions of the optic nerve. AJR Am J Roentgenol 140(5):869–874

    Article  CAS  PubMed  Google Scholar 

  77. Piccirilli M, Lenzi J et al (2006) Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature. Childs Nerv Syst 22(10):1332–1337

    Article  PubMed  Google Scholar 

  78. Prados MD, Edwards MS et al (1997) Treatment of pediatric low-grade gliomas with a nitrosourea-based multiagent chemotherapy regimen. J Neurooncol 32(3):235–241

    Article  CAS  PubMed  Google Scholar 

  79. Rodriguez FJ, Giannini C et al (2008) Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes. J Neuropathol Exp Neurol 67(12):1194–1204

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  80. Rozen WM, Joseph S et al (2008) Spontaneous regression of low-grade gliomas in pediatric patients without neurofibromatosis. Pediatr Neurosurg 44(4):324–328

    Article  PubMed  Google Scholar 

  81. Rush SZ, Abel TW et al (2010) Activation of the Hedgehog pathway in pilocytic astrocytomas. Neuro Oncol 12(8):790–798

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  82. Sawamura Y, Kamada K et al (2008) Role of surgery for optic pathway/hypothalamic astrocytomas in children. Neuro Oncol 10(5):725–733

    Article  PubMed Central  PubMed  Google Scholar 

  83. Schindera C, Wingeier K et al (2011) Macrocephaly in neurofibromatosis type 1: a sign post for optic pathway gliomas? Childs Nerv Syst 27(12):2107–2111

    Article  PubMed  Google Scholar 

  84. Shamji MF, Benoit BG (2007) Syndromic and sporadic pediatric optic pathway gliomas: review of clinical and histopathological differences and treatment implications. Neurosurg Focus 23(5):E3

    Article  PubMed  Google Scholar 

  85. Sharif S, Ferner R et al (2006) Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy. J Clin Oncol 24(16):2570–2575

    Article  PubMed  Google Scholar 

  86. Sharif S, Upadhyaya M et al (2011) A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype-phenotype correlations. J Med Genet 48(4):256–260

    Article  CAS  PubMed  Google Scholar 

  87. Shofty B, Ben-Sira L et al (2012) Optic nerve sheath diameter on MR imaging: establishment of norms and comparison of pediatric patients with idiopathic intracranial hypertension with healthy controls. AJNR Am J Neuroradiol 33(2):366–369

    Article  CAS  PubMed  Google Scholar 

  88. Shofty B, Ben-Sira L et al (2011) Visual outcome following chemotherapy for progressive optic pathway gliomas. Pediatr Blood Cancer 57(3):481–485

    Article  PubMed  Google Scholar 

  89. Shofty B, Weizman L et al (2011) MRI internal segmentation of optic pathway gliomas: clinical implementation of a novel algorithm. Childs Nerv Syst 27(8):1265–1272

    Article  PubMed  Google Scholar 

  90. Steinbok P, Hentschel S et al (2002) Management of optic chiasmatic/hypothalamic astrocytomas in children. Can J Neurol Sci 29(2):132–138

    PubMed  Google Scholar 

  91. Sutton LN, Molloy PT et al (1995) Long-term outcome of hypothalamic/chiasmatic astrocytomas in children treated with conservative surgery. J Neurosurg 83(4):583–589

    Article  CAS  PubMed  Google Scholar 

  92. Taylor M, Couto-Silva AC et al (2012) Hypothalamic-pituitary lesions in pediatric patients: endocrine symptoms often precede neuro-ophthalmic presenting symptoms. J Pediatr 161(5):855–863

    Article  PubMed  Google Scholar 

  93. Taylor T, Jaspan T et al (2008) Radiological classification of optic pathway gliomas: experience of a modified functional classification system. Br J Radiol 81(970):761–766

    Article  CAS  PubMed  Google Scholar 

  94. Thiagalingam S, Flaherty M et al (2004) Neurofibromatosis type 1 and optic pathway gliomas: follow-up of 54 patients. Ophthalmology 111(3):568–577

    Article  PubMed  Google Scholar 

  95. Tian Y, Rich BE et al (2011) Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn 13(6):669–677

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  96. Tow SL, Chandela S et al (2003) Long-term outcome in children with gliomas of the anterior visual pathway. Pediatr Neurol 28(4):262–270

    Article  PubMed  Google Scholar 

  97. Weizman L, Ben Sira L et al (2012) Automatic segmentation, internal classification, and follow-up of optic pathway gliomas in MRI. Med Image Anal 16(1):177–188

    Article  CAS  PubMed  Google Scholar 

  98. Wisoff JH, Abbott R et al (1990) Surgical management of exophytic chiasmatic-hypothalamic tumors of childhood. J Neurosurg 73(5):661–667

    Article  CAS  PubMed  Google Scholar 

  99. Zoeller GK, Brathwaite CD et al (2010) Malignant transformation of an optic pathway glioma without prior radiation therapy. J Neurosurg Pediatr 5(5):507–510

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Neurosurgery, Dana Children’s Hospital, Tel-Aviv Medical Center, Tel Aviv University, 6th Weizmann St., Tel-Aviv, 64239, Israel

    Ben Shofty, Liat Ben-Sira, Anat Kesler & Shlomi Constantini

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  1. Ben Shofty
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  2. Liat Ben-Sira
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  3. Anat Kesler
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  4. Shlomi Constantini
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Correspondence to Shlomi Constantini .

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  1. Medizinische Fakultät, Univ.Klinikum Bonn Med. Einrichtungen, Bonn, Germany

    Johannes Schramm

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Shofty, B., Ben-Sira, L., Kesler, A., Constantini, S. (2015). Optic Pathway Gliomas. In: Schramm, J. (eds) Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 42. Springer, Cham. https://doi.org/10.1007/978-3-319-09066-5_7

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