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Obesity and Glucose Metabolism

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Multidisciplinary Approach to Obesity

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Abstract

Obesity is associated with multiple metabolic alterations that are risk factors for glucose homeostasis abnormalities, cardiovascular diseases, and nonalcoholic fatty liver disease. It is believed that insulin resistance in the adipose tissue, liver, and skeletal muscle is crucial in the pathogenesis of these metabolic abnormalities. Adipocytes are key regulators of whole-body energy homeostasis, and altered adipose tissue glucose metabolism is also an important cause of insulin resistance and metabolic function. Adipose tissue contributes to the development of obesity-related glucose abnormalities through excessive release of free fatty acids (FFA), adipokines, cytokines, and macrophage infiltration.

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Authors and Affiliations

  1. Division of Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, Rome, Italy

    Nicola Napoli & Paolo Pozzilli

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  1. Nicola Napoli
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  2. Paolo Pozzilli
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Correspondence to Nicola Napoli .

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Editors and Affiliations

  1. Department of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Nutrition, Sapienza University, Rome, Italy

    Andrea Lenzi

  2. Department of Movement, Human and Health Sciences, Unit of Endocrinology, Foro Italico University, Rome, Italy

    Silvia Migliaccio

  3. Department of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Nutrition, Sapienza University, Rome, Italy

    Lorenzo Maria Donini

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Napoli, N., Pozzilli, P. (2015). Obesity and Glucose Metabolism. In: Lenzi, A., Migliaccio, S., Donini, L. (eds) Multidisciplinary Approach to Obesity. Springer, Cham. https://doi.org/10.1007/978-3-319-09045-0_11

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  • DOI: https://doi.org/10.1007/978-3-319-09045-0_11

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