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Acinic Cell Carcinoma

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Acinic cell carcinoma affects children and adults and presents at a mean age of approximately 50 years. Women are involved slightly more than men. The majority of cases involve major salivary glands, presenting as single or multiple masses. Most cases of acinic cell carcinoma behave as low- to intermediate-grade malignancies; however, a subset of cases with high-grade transformation (necrosis, elevated mitotic activity, and cytomorphologic atypia) are predisposed to recurrence, lymph node involvement, and distant metastasis. Acinic cell carcinoma may be well-circumscribed or infiltrative, comprised of multiple cell types (e.g., acinar, ductal), and exhibit a variety of architectural patterns (follicular, solid, and microcystic) (Figs. 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 6.10, 6.11, 6.12, 6.13, 6.14, 6.15, 6.16, 6.17, 6.18, 6.19, 6.20, 6.21, 6.22, 6.23, 6.24, 6.25, 6.26, 6.27, 6.28, 6.29, 6.30, 6.31, 6.32, 6.33, 6.34, 6.35, 6.36, 6.37, 6.38, 6.39, 6.40, 6.41, 6.42 and 6.43).


  • Acinic cell adenocarcinoma
  • Acinar cell carcinoma
  • Acinic cell tumor

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  • DOI: 10.1007/978-3-319-09021-4_6
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García, J.J. (2019). Acinic Cell Carcinoma. In: Atlas of Salivary Gland Pathology. Springer, Cham.

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