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Mechanisms of Circadian Systems in Animals and Their Clinical Relevance pp 261–287Cite as

Physiopathology of Circadian Rhythms: Understanding the Biochemical Mechanisms of Obesity and Cancer

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Abstract

Obesity and cancer have become urgent and pressing health problems in industrialized societies. Both diseases are interrelated: overweight and obesity favor tumorogenesis in a variety of tissues and organs, mainly supported in the biochemical alterations caused by a diabetogenic state and the pro-inflammatory condition associated. An additional perspective involves disturbances in circadian rhythms which are associated with a metabolic dysfunction; circadian disruption has also been considered as a carcinogenic condition for humans based in evidence that link dysfunctional control of cell division and differentiation to an altered circadian molecular clock. In this chapter, we review recent findings that demonstrate the interplay between metabolism and circadian rhythmicity, as well as the repercussions involved in the physiopathology of obesity and cancer.

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Acknowledgments

We are in debt with Nutriologist Fernando López Barrera for design of Fig. 14.2 and Dr. Dorothy Pless for revision and enrich the English redaction. Research in M. D.-M.’s laboratory is supported by projects 129-511 (CONACyT) and 202412-23 (PAPIIT, UNAM).

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    Authors and Affiliations

    1. Facultad de Ciencias, Unidad Multidisciplinaria de Docencia e Investigación, Universidad Nacional Autónoma de México, Querétaro, 76230, QRO, México

      Manuel Miranda-Anaya

    2. Department of Cellular and Molecular Neurobiology, Neurobiology Institute, Campus UNAM-Juriquilla, Querétaro, 76230, QRO, México

      Manuel Miranda-Anaya, Christian Molina-Aguilar, Olivia Vázquez-Martínez & Mauricio Díaz-Muñoz

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    Correspondence to Mauricio Díaz-Muñoz .

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    1. Instituto de Fisiología Celular, Universidad Nacional Autonoma de México, México, Distrito Federal, Mexico

      Raúl Aguilar-Roblero

    2. Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, Mexico

      Mauricio Díaz-Muñoz

    3. Facultad de Ciencias, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico

      Mária Luisa Fanjul-Moles

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    Miranda-Anaya, M., Molina-Aguilar, C., Vázquez-Martínez, O., Díaz-Muñoz, M. (2015). Physiopathology of Circadian Rhythms: Understanding the Biochemical Mechanisms of Obesity and Cancer. In: Aguilar-Roblero, R., Díaz-Muñoz, M., Fanjul-Moles, M. (eds) Mechanisms of Circadian Systems in Animals and Their Clinical Relevance. Springer, Cham. https://doi.org/10.1007/978-3-319-08945-4_14

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