Instrumentation for the Coagulation Laboratory
A broad spectrum of coagulation analyzers is available for purchase on the market today. Laboratories can choose from manual, semi-automated or fully automated, moderate or high-throughput analyzers with narrow or broad assay menus depending upon clinical and test volume requirements. These laboratory-based instruments require plasma prepared from spun, anticoagulated whole blood for analysis. In addition, a number of point of care (POC) devices designed to analyze fresh whole blood are available for use on hospital patient care units, in clinics and doctors’ offices, and even in patients’ homes. For a current summary of marketed devices, the reader is referred to the annual College of American Pathologists summary list of laboratory-based coagulation analyzers and their attributes published on the College’s web site (www.cap.org). A separate list of point of care analyzers can also be found on the site.
KeywordsInternational Normalize Ratio Platelet Function Activate Clotting Time Clot Lysis Platelet Agonist
- 4.Point-of-care monitoring of anticoagulation therapy; approved guideline. CLSI document H49-A. Wayne: Clinical and Laboratory Standards Institute; 2004.Google Scholar
- 6.Murray ET, Fitzmaurice DA, McCahon D. Point of care testing for INR monitoring; where are we now? BMJ. 2004;127:373–8.Google Scholar
- 11.Santrach PJ. Point-of-care hematology, hemostasis, and thrombolysis testing. In: Kost GJ, editor. Principals and practice of point-of-care testing. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 157–80.Google Scholar
- 12.Kratz A, Van Cott EM. Activated clotting time methods and clinical applications. Point of Care. 2005;4:90–4.Google Scholar
- 17.Hayward CPM, Harrison P, Cataneo TL, et al. Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Platelet function analyzer (PFA)-100® closure time in the evaluation of platelet disorders and platelet function. J Thromb Haemost. 2006;4:312–19.Google Scholar