Skip to main content

Coagulation Testing and Transfusion Medicine

  • Chapter
  • First Online:
Laboratory Hemostasis

Abstract

Transfusion Services are presented with many challenging coagulation problems. Most cases gain attention when out of the ordinary requests for blood products are received. The Transfusion Medicine Physician is often brought into a clinical scenario that has already become an emergency and quick response is imperative [1–8]. Decisions often have to be made empirically, or with the help of a very limited coagulation test menu. This chapter will focus on maximizing information from a short coagulation test menu, reviewing the tools available to correct coagulopathies, and applying these tests to emergency situations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Hardy JF, de Moerloose P, Samama CM. The coagulopathy of massive transfusion. Vox Sang. 2005;89:123–7.

    Article  PubMed  Google Scholar 

  2. Hess JR, Zimrin AB. Massive blood transfusion for trauma. Curr Opin Hematol. 2005;12:488–92.

    Article  PubMed  Google Scholar 

  3. Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth. 2005;95:130–9.

    Article  PubMed  CAS  Google Scholar 

  4. Hess JR, Hiippala S. Optimizing the use of blood products in trauma care. Crit Care. 2005;9(5 Suppl):5S–10.

    Google Scholar 

  5. Cinà CS, Clase CM. Coagulation disorders and blood product use in patients undergoing thoracoabdominal aortic aneurysm repair. Transfus Med Rev. 2005;19:143–54.

    Article  PubMed  Google Scholar 

  6. Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfus Med Rev. 2003;17:223–31.

    Article  PubMed  Google Scholar 

  7. Hess JR, Thomas MJG. Blood use in war and disaster: lessons from the past century. Transfusion. 2003;43:1622–33.

    Article  PubMed  CAS  Google Scholar 

  8. Hirshberg A, Dugas M, Banez EI, et al. Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation. J Trauma. 2003;54:454–63.

    Article  PubMed  Google Scholar 

  9. Avidan MS, Alcock EL, Da Fonseca J, et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth. 2004;92:178–86.

    Article  PubMed  CAS  Google Scholar 

  10. Lehman CL, Wilson LW, Rodgers GM. Analytic validation and clinical evaluation of the STA LIATEST immunoturbidimetric D-dimer assay for the diagnosis of disseminated intravascular coagulation. Am J Clin Pathol. 2004;122:178–84.

    Article  PubMed  Google Scholar 

  11. Blaylock RC. Issues of unwashed wound drainage blood following orthopedic surgery. In: Tawes Jr RL, editor. Autotransfusion: therapeutic principles and trends. Detroit: Gregory Appleston; 1997. p. 339–43.

    Google Scholar 

  12. Blaylock RC, Carlson KC, Morgan JM, et al. In-vitro analysis of ‘shed blood’ from patients undergoing total knee replacement. Am J Clin Pathol. 1994;101:365–9.

    PubMed  CAS  Google Scholar 

  13. McNulty SE, Sasso P, Vesci J, et al. Platelet concentrate effects on thromboelastography. J Cardiothorac Vasc Anesth. 1997;11:828–30.

    Article  PubMed  CAS  Google Scholar 

  14. Craft RM, Chavez JJ, Bresee SJ, et al. A novel modification of the Thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation. J Lab Clin Med. 2004;143:301–9.

    Article  PubMed  Google Scholar 

  15. Apheresis. In: Brecher ME, editor. AABB technical manual, 15th ed. Bethesda: AABB; 2005. p. 139–61.

    Google Scholar 

  16. Rodgers G. Acquired coagulation disorders. In: Kjeldsberg CR, editor. Practical diagnosis of hematologic disorders. 4th ed. Chicago: ASCP Press; 2006. p. 357–70.

    Google Scholar 

  17. Dzik W. Supplement: reversal of drug-induced anticoagulation: old solutions and new problems. Transfusion. 2012;52 Suppl 1:45S–55.

    Article  PubMed  CAS  Google Scholar 

  18. Levy JH, Faraoni D, Spring JL, et al. Managing new oral anticoagulants in the perioperative and intensive care unit setting. Anesthesiology. 2013;118:1466–74.

    Article  PubMed  CAS  Google Scholar 

  19. Kaatz S, Kouides PA, Garcia DA, et al. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol. 2012;87 Suppl 1:S141–5.

    Article  PubMed  CAS  Google Scholar 

  20. Lu G, DeGuzman FR, Hollenbach SJ, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013;19:446–51.

    Article  PubMed  CAS  Google Scholar 

  21. Eerenberg ES, Kamphuisen PW, Sijpkens MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124(14):1573–9.

    Article  PubMed  CAS  Google Scholar 

  22. Schiele F, van Ryn J, Canada K, et al. A specific antidote for dabigatran: functional and structural characterization. Blood. 2013;121:3554–62.

    Article  PubMed  CAS  Google Scholar 

  23. Marlu R, Hodaj E, Paris A, et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost. 2012;108:217–24.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert C. Blaylock MD .

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Blaylock, R.C., Lehman, C.M. (2015). Coagulation Testing and Transfusion Medicine. In: Laboratory Hemostasis. Springer, Cham. https://doi.org/10.1007/978-3-319-08924-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-08924-9_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-08923-2

  • Online ISBN: 978-3-319-08924-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics