Abstract
Transfusion Services are presented with many challenging coagulation problems. Most cases gain attention when out of the ordinary requests for blood products are received. The Transfusion Medicine Physician is often brought into a clinical scenario that has already become an emergency and quick response is imperative [1–8]. Decisions often have to be made empirically, or with the help of a very limited coagulation test menu. This chapter will focus on maximizing information from a short coagulation test menu, reviewing the tools available to correct coagulopathies, and applying these tests to emergency situations.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hardy JF, de Moerloose P, Samama CM. The coagulopathy of massive transfusion. Vox Sang. 2005;89:123–7.
Hess JR, Zimrin AB. Massive blood transfusion for trauma. Curr Opin Hematol. 2005;12:488–92.
Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth. 2005;95:130–9.
Hess JR, Hiippala S. Optimizing the use of blood products in trauma care. Crit Care. 2005;9(5 Suppl):5S–10.
Cinà CS, Clase CM. Coagulation disorders and blood product use in patients undergoing thoracoabdominal aortic aneurysm repair. Transfus Med Rev. 2005;19:143–54.
Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfus Med Rev. 2003;17:223–31.
Hess JR, Thomas MJG. Blood use in war and disaster: lessons from the past century. Transfusion. 2003;43:1622–33.
Hirshberg A, Dugas M, Banez EI, et al. Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation. J Trauma. 2003;54:454–63.
Avidan MS, Alcock EL, Da Fonseca J, et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth. 2004;92:178–86.
Lehman CL, Wilson LW, Rodgers GM. Analytic validation and clinical evaluation of the STA LIATEST immunoturbidimetric D-dimer assay for the diagnosis of disseminated intravascular coagulation. Am J Clin Pathol. 2004;122:178–84.
Blaylock RC. Issues of unwashed wound drainage blood following orthopedic surgery. In: Tawes Jr RL, editor. Autotransfusion: therapeutic principles and trends. Detroit: Gregory Appleston; 1997. p. 339–43.
Blaylock RC, Carlson KC, Morgan JM, et al. In-vitro analysis of ‘shed blood’ from patients undergoing total knee replacement. Am J Clin Pathol. 1994;101:365–9.
McNulty SE, Sasso P, Vesci J, et al. Platelet concentrate effects on thromboelastography. J Cardiothorac Vasc Anesth. 1997;11:828–30.
Craft RM, Chavez JJ, Bresee SJ, et al. A novel modification of the Thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation. J Lab Clin Med. 2004;143:301–9.
Apheresis. In: Brecher ME, editor. AABB technical manual, 15th ed. Bethesda: AABB; 2005. p. 139–61.
Rodgers G. Acquired coagulation disorders. In: Kjeldsberg CR, editor. Practical diagnosis of hematologic disorders. 4th ed. Chicago: ASCP Press; 2006. p. 357–70.
Dzik W. Supplement: reversal of drug-induced anticoagulation: old solutions and new problems. Transfusion. 2012;52 Suppl 1:45S–55.
Levy JH, Faraoni D, Spring JL, et al. Managing new oral anticoagulants in the perioperative and intensive care unit setting. Anesthesiology. 2013;118:1466–74.
Kaatz S, Kouides PA, Garcia DA, et al. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol. 2012;87 Suppl 1:S141–5.
Lu G, DeGuzman FR, Hollenbach SJ, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013;19:446–51.
Eerenberg ES, Kamphuisen PW, Sijpkens MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124(14):1573–9.
Schiele F, van Ryn J, Canada K, et al. A specific antidote for dabigatran: functional and structural characterization. Blood. 2013;121:3554–62.
Marlu R, Hodaj E, Paris A, et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost. 2012;108:217–24.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Blaylock, R.C., Lehman, C.M. (2015). Coagulation Testing and Transfusion Medicine. In: Laboratory Hemostasis. Springer, Cham. https://doi.org/10.1007/978-3-319-08924-9_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-08924-9_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08923-2
Online ISBN: 978-3-319-08924-9
eBook Packages: MedicineMedicine (R0)