Skip to main content

How to Choose My Treatment

  • Chapter
  • First Online:
  • 813 Accesses

Abstract

Determining treatment for nail psoriasis is as much an art as science. All patients with nail psoriasis benefit from education about psoriatic nail disease, the timeline for nail improvement, strategies to protect nails from exacerbating factors, and the overall treatment landscape for psoriatic nail disease. Factors such as nail disease severity, impact on quality of life, risk versus benefit ratio, the severity of plaque psoriasis and psoriatic arthritis, and cost should be considered when choosing treatment. In general, topical medications, intralesional, and device- based therapy are early steps on the therapeutic ladder, and systemic medications including biologics are used in moderate to severe psoriatic disease and when the nail psoriasis does not respond to local therapy.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Reich K. Approach to managing patients with nail psoriasis. J Eur Acad Dermatol Venereol. 2009;23:15–21.

    Article  PubMed  Google Scholar 

  2. de Vries AC, Bogaards NA, Hooft L, Velema M, Pasch M, Lebwohl M, Spuls PI. Interventions for nail psoriasis. Cochrane Database Syst Rev. 2013;(1):CD007633.

    Google Scholar 

  3. Tan ES, Chong WS, Tey HL. Nail psoriasis: a review. Am J Clin Dermatol. 2012;13(6):375–88.

    Article  PubMed  Google Scholar 

  4. Oram Y, Akkaya AD. Treatment of nail psoriasis: common concepts and new trends. Dermatol Res Pract. 2013;2013:1–13.

    Article  Google Scholar 

  5. Demirsoy EO, Kıran R, Salman S, et al. Effectiveness of systemic treatment agents on psoriatic nails: a comparative study. J Drugs Dermatol. 2013;12(9):1039–43.

    PubMed  Google Scholar 

  6. Jiaravuthisan MM, Dasseville D, Vender RB, et al. Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol. 2007;57:1–27.

    Article  PubMed  Google Scholar 

  7. Augustin M, Krüger K, Radtke MA, Schwippl I, Reich K. Disease severity, quality of life and health care in plaque-type psoriasis: a multicenter cross-sectional study in Germany. Dermatology. 2008;216(4):366–72.

    Article  PubMed  CAS  Google Scholar 

  8. Mercy M, Kwasny M, Cordoro KM, et al. Clinical manifestations of pediatric psoriasis: results of a multicenter study in the United States. Pediatr Dermatol. 2013;30(4):424–8.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Hallaji Z, Babaeijandaghi F, Akbarzadeh M, et al. A significant association exists between the severity of nail and skin involvement in psoriasis. J Am Acad Dermatol. 2012;66:e12–3.

    Article  PubMed  Google Scholar 

  10. Van den Bosch F, Manger B, Goupille P, et al. Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions. Ann Rheum Dis. 2010;69:394–9.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Maejima H, Taniguchi T, Watarai A, Katsuoka K. Evaluation of nail disease in psoriatic arthritis by using a modified nail psoriasis severity score index. Int J Dermatol. 2010;49(8):901–6.

    Article  PubMed  Google Scholar 

  12. de Jong EM, Seegers BA, Gulinck MK, et al. Psoriasis of the nails associated with disability in a large number of patients: results of a recent interview with 1,728 patients. Dermatology. 1996;193:300–3.

    Article  PubMed  Google Scholar 

  13. Augustin M, Krüger K, Radtke MA, Schwippl I, Reich K. Disease severity, quality of life and health care in plaquetype psoriasis: a multicenter cross-sectional study in Germany. Dermatology. 2008;216(4):366–72.

    Article  PubMed  CAS  Google Scholar 

  14. de Berker D. Management of psoriatic nail disease. Semin Cutan Med Surg. 2009;28(1):39–43.

    Article  PubMed  Google Scholar 

  15. Gupta AK, Lynde CW, Jain HC, et al. A higher prevalence of onychomycosis in psoriatics compared with non-psoriatics: a multicenter study. Br J Dermatol. 1997;136:786–9.

    Article  PubMed  CAS  Google Scholar 

  16. Sánchez-Regaña M, Videla S, Villoria J, et al. Prevalence of fungal involvement in a series of patients with psoriasis. Clin Exp Dermatol. 2008;33:194–5.

    Article  PubMed  Google Scholar 

  17. Sais G, Jucglà A, Peyri J. Prevalence of dermatophyte onychomycosis in Spain: a cross-sectional study. Br J Dermatol. 1995;132:758–61.

    Article  PubMed  CAS  Google Scholar 

  18. Vender RB, Lynde CW, Poulin Y. Prevalence and epidemiology of onychomycosis. J Cutan Med Surg. 2006;10:S28–33.

    PubMed  Google Scholar 

  19. Sánchez Regaña M, Martín Ezquerra G, Umbert Millet P, Llambí Mateos F. Treatment of nail psoriasis with 8% clobetasol nail lacquer: positive experience in 10 patients,”. J Eur Acad Dermatol Venereol. 2005;19(5):573–7.

    Article  PubMed  Google Scholar 

  20. De Simone C, Maiorino A, Tassone F, D’Agostino M, Caldarola G. Tacrolimus 0.1% ointment in nail psoriasis: a randomized controlled open-label study. J Eur Acad Dermatol Venereol. 2013;27(8):1003–6.

    Article  PubMed  Google Scholar 

  21. Rigopoulos D, Gregoriou S, Katsambas A. Treatment of psoriatic nails with tazarotene cream 0.1 % vs. clobetasol propionate 0.05 % cream: a double-blind study. Acta Derm Venereol. 2007;87(2):167–8.

    Article  PubMed  CAS  Google Scholar 

  22. Tosti A, Piraccini BM, Cameli N, et al. Calcipotriol ointment in nail psoriasis: a controlled double-blind comparison with betamethasone dipropionate and salicylic acid. Br J Dermatol. 1998;139(4):655–9.

    Article  PubMed  CAS  Google Scholar 

  23. Yamamoto T, Katayama I, Nishioka K. Topical anthralin therapy for refractory nail psoriasis. J Dermatol. 1998;25(4):231–3.

    PubMed  CAS  Google Scholar 

  24. Fredriksson T. Topically applied fluorouracil in the treatment of psoriatic nails. Arch Dermatol. 1974;110(5):735–6.

    Article  PubMed  CAS  Google Scholar 

  25. Cannavò SP, Guarneri F, Vaccaro M, Borgia F, Guarneri B. Treatment of psoriatic nails with topical cyclosporin: a prospective, randomized placebo-controlled study. Dermatology. 2003;206(2):153–6.

    Article  PubMed  Google Scholar 

  26. Liang CY, Lin TY, Lin YK. Successful treatment of pediatric nail psoriasis with periodic pustular eruption using topical indigo naturalis oil extract. Pediatr Dermatol. 2013;30:117–9.

    Article  PubMed  Google Scholar 

  27. Marx JL, Scher RK. Response of psoriatic nails to oral photochemotherapy. Arch Dermatol. 1980;116(9):1023–4.

    Article  PubMed  CAS  Google Scholar 

  28. Rados J, Dobrić I, Pasić A, Lipozencić J, Ledić-Drvar D, Stajminger G. Normalization in the appearance of severely damaged psoriatic nails using soft x-rays. A case report,”. Acta Dermatovenerol Croat. 2007;15:27–32.

    PubMed  Google Scholar 

  29. Oram Y, Karincaoğlu Y, Koyuncu E, Kaharaman F. Pulsed dye laser in the treatment of nail psoriasis. Dermatol Surg. 2010;36(3):377–81.

    Article  PubMed  CAS  Google Scholar 

  30. Treewittayapoom C, Singvahanont P, Chanprapaph K, Haneke E. The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: a randomized, double-blind, intrapatient left-to-right study. J Am Acad Dermatol. 2012;66:807–12.

    Article  PubMed  Google Scholar 

  31. Fernández-Guarino M, Harto A, Sánchez-Ronco M, García-Morales I, Jaén P. Pulsed dye laser vs. photodynamic therapy in the treatment of refractory nail psoriasis: a comparative pilot study. J Eur Acad Dermatol Venereol. 2009;23(8):891–5.

    Article  PubMed  Google Scholar 

  32. Tosti A, Ricotti C, Romanelli P, Cameli N, Piraccini BM. Evaluation of the efficacy of acitretin therapy for nail psoriasis. Arch Dermatol. 2009;145(3):269–71.

    Article  PubMed  CAS  Google Scholar 

  33. Ricceri F, Pescitelli L, Tripo L, Bassi A, Prignano F. Treatment of severe nail psoriasis with acitretin: an impressive therapeutic result. Dermatol Ther. 2013;26:77–8.

    Article  PubMed  CAS  Google Scholar 

  34. Feliciani C, Zampetti A, Forleo P, et al. Nail psoriasis: combined therapy with systemic cyclosporin and topical calcipotriol. J Cutan Med Surg. 2004;8(2):122–5.

    Article  PubMed  Google Scholar 

  35. Mahrle G, Schulze HJ, Färber L, Weidinger G, Steigleder GK. Low-dose short-term cyclosporine versus etretinate in psoriasis: improvement of skin, nail, and joint involvement. J Am Acad Dermatol. 1995;32:78–88.

    Article  PubMed  CAS  Google Scholar 

  36. Sánchez-Regaña M, Sola-Ortigosa J, Alsina-Gibert M, Vidal-Fernández M, Umbert-Millet P. Nail psoriasis: a retrospective study on the effectiveness of systemic treatments (classical and biological therapy). J Eur Acad Dermatol Venereol. 2011;25(5):579–88.

    Article  PubMed  Google Scholar 

  37. Gümüşel M, Özdemir M, Mevlitoğlu I, Bodur S. Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study. J Eur Acad Dermatol Venereol. 2011;25:1080–4.

    Article  PubMed  Google Scholar 

  38. Rich P, Griffiths CEM, Reich K, et al. Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. J Am Acad Dermatol. 2008;58(2):224–31.

    Article  PubMed  Google Scholar 

  39. Van den Bosch F, Manger B, Goupille P, et al. Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions. Ann Rheum Dis. 2010;69(2):394–9.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Ortonne JP, Paul C, Berardesca E, Marino V, Gallo G, Brault Y, Germain JM. A 24-week randomized clinical trial investigating the efficacy and safety of two doses of etanercept in nail psoriasis. Br J Dermatol. 2013;168(5):1080–7.

    Article  PubMed  CAS  Google Scholar 

  41. Luger TA, Barker J, Lambert J, et al. Sustained improvement in joint pain and nail symptoms with etanercept therapy in patients with moderate-to-severe psoriasis. J Eur Acad Dermatol Venereol. 2009;23(8):896–904.

    Article  PubMed  CAS  Google Scholar 

  42. Kavanaugh A, Mclnnes I, Mease P, et al. Golimumab, a new human tumor necrosis factor α antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: twenty-four-week efficacy and safety results of a randomized, placebo-controlled study. Arthritis Rheum. 2009;60(4):976–86.

    Article  PubMed  CAS  Google Scholar 

  43. Parrish CA, Sobera JO, Robbins CM, Cantrell WC, Desmond RA, Elewski BE. Alefacept in the treatment of psoriatic nail disease: a proof of concept study. J Drugs Dermatol. 2006;5(4):339–40.

    PubMed  Google Scholar 

  44. Rich P, Bourcier M, Sofen H, Fakharzadeh S, Wasfi Y, Wang Y, Kerkmann U, Ghislain P-D, Poulin Y, The PHOENIX 1 Investigators. Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. Br J Dermatol. 2014;170:398–407.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Phoebe Rich MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Hare, A.Q., Jefferson, J., Rich, P. (2014). How to Choose My Treatment. In: Rigopoulos, D., Tosti, A. (eds) Nail Psoriasis. Springer, Cham. https://doi.org/10.1007/978-3-319-08810-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-08810-5_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-08809-9

  • Online ISBN: 978-3-319-08810-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics