Abstract
Silicon carbide is a well-known semiconductor with excellent biocompatibility and at least two factors contribute to this favorable characteristic. The first one is that the compound does not contain heavy metals which tend to be detrimental to the human body, and the second one is that neither silicon nor carbon causes deleterious effects such as cytotoxicity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ota T, Takahashi M, Hibi T, Ozawa M, Suzuki S, Hikichi Y, Suzuki H (1995) Biomimetic process for producing SiC “wood”. J Am Ceram Soc 78:3409–3411
Greil P, Lifka T, Kaindl A (1998) Biomorphic cellular silicon carbide ceramics from wood: I. processing and microstructure. J Eur Ceram Soc 18:1961–1973
Greil P, Lifka T, Kaindl A (1998) Biomorphic cellular silicon carbide ceramics from wood: II. mechanical properties. J Eur Ceram Soc 18:1975–1983
Vogli E, Sieber H, Greil P (2002) Biomorphic SiC-ceramic prepared by Si-vapor phase infiltration of wood. J Eur Ceram Soc 22:2663–2668
Vogli E, Mukerji J, Hoffman C, Kladny R, Sieber H, Greil P (2001) Conversion of oak to cellular silicon carbide ceramic by gas-phase reaction with silicon monoxide. J Am Ceram Soc 84:1236–1240
Qian J-M, Wang J-P, Qiao G-J, Jin Z-H (2004) Preparation of porous SiC ceramic with a woodlike microstructure by sol-gel and carbothermal reduction processing. J Eur Ceram Soc 24:3251–3259
Shin Y, Wang C, Exarhos GJ (2005) Synthesis of SiC ceramics by the carbothermal reduction of mineralized wood with silica. Adv Mater 17:73–77
Martínez-Fernández J, Valera-Feria FM, Singh M (2000) High temperature compressive mechanical behavior of joined biomorphic silicon carbide ceramics. Scripta Mater 43:813–818
Singh M, Salem JA (2002) Mechanical properties and microstructure of biomorphic silicon carbide ceramics fabricated from wood precursors. J Eur Ceram Soc 22:2709–2717
González P, Serra J, Liste S, Chiussi S, León B, Pérez-Amor M, Martínez-Fernández J, de Arellano-López AR, Varela-Feria FM (2003) New biomorphic SiC ceramics coated with bioactive glass for biomedical applications. Biomaterials 24:4827–4832
Aspenberg P, Anttila A, Konttinen YT, Lappalainen R, Goodman SB, Nordsletten L, Santavirta S (1996) Benign response to particles of diamond and SiC: bone chamber studies of new joint replacement coating materials in rabbits. Biomaterials 17:807–812
Santavirta S, Takagi M, Nordsletten L, Anttila A, Lappalainen R, Konttinen YT (1998) Biocompatibility of silicon carbide in colony formation test in vitro. A promising new ceramic THR implant coating material. Arch Orthop Trauma Surg 118:89–91
Cogan SF, Edell DJ, Guzelian AA, Liu YP, Edell R (2003) Plasma-enhanced chemical vapor deposited silicon carbide as an implantable dielectric coating. J Biomed Mater Res A. 67:856–867
Rosi NL, Mirkin CA (2005) Nanostructures in biodiagnostics. Chem Rev 105:1547–1562
Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S (2005) Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307:538–544
Medintz IL, Uyeda HT, Goldman ER, Mattoussi H (2005) Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater 4:435–446
Derfus AM, Chan WCW, Bhatia SN (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18
Nel A, Xia T, Mädler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627
Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Persp 113:823–839
Lewinski N, Colvin V, Drezek R (2008) Cytotoxicity of nanoparticles. Small 4:26–49
Fan J, Chu PK (2010) Group IV nanoparticles: synthesis, properties, and biological applications. Small 6:2080–2098
Fan J, Li H, Jiang J, So LKY, Lam YW, Chu PK (2008) 3C-SiC nanocrystals as fluorescent biological labels. Small 4:1058–1062
Barillet S, Simon-Deckers A, Herlin-Boime N, Mayne-L’Hermite M, Reynaud C, Cassio D, Gouget B, Carrière M (2010) Toxicological consequences of TiO2, SiC nanoparticles and multi-walled carbon nanotubes exposure in several mammalian cell types: an in vitro study. J Nanopart Res 12:61–73
Barillet S, Jugan M-L, Laye M, Leconte Y, Herlin-Boime N, Reynaud C, Carrière M (2010) In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: cyto-, genotoxicity and oxidative stress. Toxicol Lett 198:324–330
Pourchez J, Forest V, Boumahdi N, Boudard D, Tomatis M, Fubini B, Herlin-Boime N, Leconte Y, Guilhot B, Cottier M, Grosseau P (2012) In vitro cellular responses to silicon carbide nanoparticles: impact of physico-chemical features on pro-inflammatory and pro-oxidative effects. J Nanopart Res 14:1143
Lozano O, Laloy J, Alpan L, Mejia J, Rolin S, Toussaint O, Dogné J-M, Lucas S, Masereel B (2012) Effects of SiC nanoparticles orally administered in a rat model: biodistribution, toxicity and elemental composition changes in feces and organs. Toxicol Appl Pharm 264:232–245
Serdiuk T, Lysenko V, Skryshevsky VA, Géloën A (2012) Vapor phase mediated cellular uptake of sub 5 nm nanoparticles. Nanoscale Res Lett 7:212
Serdiuk T, Alekseev SA, Lysenko V, Skryshevsky VA, Géloën A (2012) Charge-driven selective localization of fluorescent nanoparticles in live cells. Nanotechnology 23:315101
Serdiuk T, Lysenko V, Mognetti B, Skryshevsky V, Géloën A (2013) Impact of cell division on intracellular uptake and nuclear targeting with fluorescent SiC-based nanoparticles. J Biophotonics 6:291–297
Beke D, Szekrényes Z, Pálfi D, Róna G, Balogh I, Maák PA, Katona G, Czigány Z, Kamarás K, Rózsa B, Buday L, Vértessy B, Gali A (2013) Silicon carbide quantum dots for bioimaging. J Mater Res 28:205–209
Birchall JD, Stanley DR, Mockford MJ, Pigott GH, Pinto PJ (1988) Toxicity of silicon carbide whiskers. J Mater Sci Lett 7:350–352
Ogami A, Morimoto Y, Yamato H, Oyabu T, Akiyama I, Tanaka I (2001) Short term effect of silicon carbide whisker to the rat lung. Ind Health 39:175–182
Morimoto Y, Ding L, Oyabu T, Hirohashi M, Kim H, Ogami A, Yamato H, Akiyama I, Hori H, Higashi T, Tanak I (2003) Expression of Clara cell secretory protein in the lungs of rats exposed to silicon carbide whisker in vivo. Toxicol Lett 145:273–279
Mwangi JN, Wang N, Ritts A, Kunz JL, Ingersoll CG, Li H, Deng B (2011) Toxicity of silicon carbide nanowires to sediment-dwelling invertebrates in water or sediment exposures. Environ Toxicol Chem 30:981–987
Jiang J, Wang J, Zhang X, Huo K, Wong HM, Yeung KWK, Zhang W, Hu T, Chu PK (2010) Activation of mitogen-activated protein kinases cellular signal transduction pathway in mammalian cells induced by silicon carbide nanowires. Biomaterials 31:7856–7862
Rosenbloom AJ, Sipe DM, Shishkin Y, Ke Y, Devaty RP, Choyke WJ (2004) Nanoporous SiC: a candidate semi-permeable material for biomedical applications. Biomed Microdevices 6:261–267
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Fan, J., Chu, P.K. (2014). Biological Applications. In: Silicon Carbide Nanostructures. Engineering Materials and Processes. Springer, Cham. https://doi.org/10.1007/978-3-319-08726-9_8
Download citation
DOI: https://doi.org/10.1007/978-3-319-08726-9_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08725-2
Online ISBN: 978-3-319-08726-9
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)