Abstract
The modern achievements in pharmacology, genetics, virology, cytology, immunology, and biochemistry paved the way for numerous discoveries in the study of leucosis at the cellular and molecular level. However, no unequivocal solution to the problem of the causes and the developmental mechanisms of this disease has been suggested. The generally accepted theory assumes that some leucosogenic agent can affect a single hemopoietic progenitor cell, which is viewed as the trigger mechanism to form the clone of leukemic cells. Further development of the disease is determined by genetics and mutations. The chromosomal instability which is intrinsic feature of a pathological clone is manifested by repeated mutations leading to formation of malignant clones and tumor progression.
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Dygai, A.M., Zhdanov, V.V. (2014). Disturbances in Hematopoietic Control During Experimental Leucosis. In: Theory of Hematopoiesis Control. SpringerBriefs in Cell Biology, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-08584-5_5
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DOI: https://doi.org/10.1007/978-3-319-08584-5_5
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