Abstract
Men with idiopathic infertility are usually treated with empirical therapies. Many over-the-counter (OTC) therapies have been historically used for male fertility, including herbs, vitamins, and nutritional supplements. Many studies demonstrate the positive effects of dietary supplementation on semen parameters and pregnancy outcomes. Conversely, many studies also demonstrate a lack of improvement and potential complications with supplementation. Oxidative stress has been a well-studied aetiology of abnormal semen parameters. Because of this, many of the current OTC therapies rely on antioxidant properties. The practice of prescribing oral antioxidant is supported by the lack of serious side effects related to this therapy, although few studies have carefully evaluated the risk of overtreatment. The most commonly studied dietary supplements include vitamin E, vitamin C, carnitines, lycopene, glutathione, selenium, omega-3 and omega-6 fatty acids, zinc, arginine, and coenzyme-Q10.
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Giammusso, B. (2015). Dietary Complements and Phytotherapy. In: Cavallini, G., Beretta, G. (eds) Clinical Management of Male Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-08503-6_16
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