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Microbubbles as Theranostics Agents

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Nano-Oncologicals

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

Clinically, ultrasound (US) has been used as a cheap, quick, and effective form of imaging that provides information useful for diagnostic purposes. With the advent of microbubbles as US contrast agents, this simple imaging technique has evolved into a tool capable of providing molecularly targeted visualization of disease and controlled delivery of therapeutics. The simple, yet robust, structure of the microbubble allows for both internal and external modifications, which lead to a wide variety of clinical uses. This chapter will introduce the reader to microbubble fabrication, stabilization, drug loading, and targeting. The reader will also be briefly exposed to specific examples of current work done using microbubbles in areas of cancer treatment and protein/gene therapies. The work reviewed here is only a small fraction of the literature available on the subject matter and serves as an introduction to microbubbles as contrast agents, drug delivery vehicles, and theranostic particles.

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Acknowledgments

J. Y. W. acknowledges support from Boston University’s College of Engineering Distinguished Faculty Fellowship, T. P. acknowledges support from the NIH/NIGMS T32 GM008764 and the NIH/NIAID T32 AI089673, and C. B. acknowledges support from the National Science Foundation Graduate Research Fellowship Program.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA

    Tuan Pham, Carl Beigie, Yoonjee Park Ph.D. & Joyce Y. Wong Ph.D.

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  1. Tuan Pham
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  2. Carl Beigie
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  3. Yoonjee Park Ph.D.
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  4. Joyce Y. Wong Ph.D.
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Correspondence to Joyce Y. Wong Ph.D. .

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Editors and Affiliations

  1. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain

    Maria José Alonso

  2. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain

    Marcos Garcia-Fuentes

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Pham, T., Beigie, C., Park, Y., Wong, J.Y. (2014). Microbubbles as Theranostics Agents. In: Alonso, M., Garcia-Fuentes, M. (eds) Nano-Oncologicals. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-08084-0_12

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