Abstract
The present thesis has led to the establishment of a new tool for the detection of proteasome inhibitors in highly heterogeneous matrices. Due to the NMR-based nature of the assay, it is not prone to common artefacts caused by quenching or autofluorescence that are responsible for the plenitude of false positive and equally negative results in high-throughput screenings conducted with UV-VIS assays.
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Stein, M.L. (2014). Discussion. In: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-07914-1_5
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DOI: https://doi.org/10.1007/978-3-319-07914-1_5
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