Abstract
Initially, a suitable subunit-selective peptide sequence had to be established, which then served as a scaffold for the NMR-active substrate.
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T.P. Dick, A.K. Nussbaum, M. Deeg, W. Heinemeyer, M. Groll, M. Schirle, W. Keilholz, S. Stevanović, D.H. Wolf, R. Huber, H.G. Rammensee, H. Schild, J. Biol. Chem. 273, 25637–25646 (1998)
M. Gaczynska, K.L. Rock, T. Spies, A.L. Goldberg, Proc. Natl. Acad. Sci. USA 91, 9213–9217 (1994)
W. Heinemeyer, J.A. Kleinschmidt, J. Saidowsky, C. Escher, D.H. Wolf, EMBO J. 10, 555–562 (1991)
M.L. Stein, P. Beck, M. Kaiser, R. Dudler, C.F. Becker, M. Groll, Proc. Natl. Acad. Sci. USA 109, 18367–18371 (2012)
T. Nazif, M. Bogyo, Proc. Natl. Acad. Sci. USA 98, 2967–2972 (2001)
M. Groll, O. Larionov, R. Huber, A. de Meijere, Proc. Natl. Acad. Sci. USA 103, 4576–4579 (2006)
U. Waspi, D. Blanc, T. Winkler, P. Ruedi, R. Dudler, Mol. Plant-Microbe Interact. 11, 727–733 (1998)
U. Waspi, P. Schweizer, R. Dudler, Plant Cell 58, 167–174 (1985)
D.C. Gross, J. Appl. Bacteriol. 58, 167–174 (1985)
J. Crawford, R. Kontnik, J. Clardy, Curr. Biol. 20, 69–74 (2010)
N.R. Waterfield, T. Ciche, D. Clarke, Annu. Rev. Microbiol. 63, 557–574 (2009)
D.J. Clarke, Cell. Microbiol. 10, 2159–2167 (2008)
M.L. Stein, P. Beck, M. Kaiser, R. Dudler, C.F. Becker, M. Groll, Proc. Natl. Acad. Sci. USA 109, 18367–18371 (2012)
M. Oka, Y. Nishiyama, S. Ohta, H. Kamei, M. Konishi, T. Miyaki, T. Oki, H. Kawaguchi, J. Antibiot. (Tokyo) 41, 1331–1337 (1988)
J. Shoji, H. Hinoo, T. Kato, T. Hattori, K. Hirooka, K. Tawara, O. Shiratori, Y. Terui, J. Antibiot. (Tokyo) 452, 755–758 (2008)
M. Groll, B. Schellenberg, A.S. Bachmann, C.R. Archer, R. Huber, T.K. Powell, S. Lindow, M. Kaiser, R. Dudler, Nature 452, 755–758 (2008)
M. Groll, L. Ditzel, J. Löwe, D. Stock, M. Bochtler, H. Bartunik, R. Huber, Nature 386, 463–471 (1997)
M. Groll, R. Huber, Methods Enzymol. 398, 329–336 (2005)
J. Löwe, D. Stock, B. Jap, P. Zwickl, W. Baumeister, R. Huber, Science 268, 533–539 (1995)
J. Clerc, N. Li, D. Krahn, M. Groll, A.S. Bachmann, B.I. Florea, H.S. Overkleeft, M. Kaiser, Chem. Commun. (Camb.) 47, 385–387 (2011)
C.R. Archer, D.L. Koomoa, E.M. Mitsunaga, J. Clerc, M. Shimizu, M. Kaiser, B. Schellenberg, R. Dudler, A.S. Bachmann, Biochem. Pharmacol. 80, 170–178 (2010)
C.R. Archer, M. Groll, M.L. Stein, B. Schellenberg, J. Clerc, M. Kaiser, T.P. Kondratyuk, J.M. Pezzuto, R. Dudler, A.S. Bachmann, Biochemistry 51, 6880–6888 (2012)
D.H. Lee, A.L. Goldberg, Trends Cell Biol. 8, 397–403 (1998)
M. Screen, M. Britton, S.L. Downey, M. Verdoes, M.J. Voges, A.E. Blom, P.P. Geurink, M.D. Risseeuw, B.I. Florea, W.A. van der Linden, A.A. Pletnev, H.S. Overkleeft, A.F. Kisselev, J. Biol. Chem. 285, 40125–40134 (2010)
P.A. Baeuerle, T. Henkel, Annu. Rev. Immunol. 12, 141–179 (1994)
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Stein, M.L. (2014). Results. In: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-07914-1_4
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