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NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens

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Abstract

The ubiquitin-proteasome system (UPS) is responsible for the directed disposal of unfolded, misfolded and short-lived proteins in eukaryotic cells and is therefore a key player in protein homeostasis. Moreover, it participates in crucial biological pathways by the degradation of signaling factors such as cyclins or the tumor suppressor p53.

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  1. Faculty of Chemistry, Department of Biochemistry, Technical University of Munich, Garching, Germany

    Martin Lorenz Stein

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Stein, M.L. (2014). Introduction. In: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-07914-1_1

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