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Emerging Roles for the FCRL Family Members in Lymphocyte Biology and Disease

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Book cover Fc Receptors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 382))

Abstract

Members of the extended Fc receptor-like (FCRL) family in humans and mice are preferentially expressed by B cells and possess tyrosine-based immunoregulatory function. Although the majority of these proteins repress B cell receptor-mediated activation, there is an emerging evidence for their bifunctionality and capacity to counter-regulate adaptive and innate signaling pathways. In light of these findings, the recent discovery of ligands for several of these molecules has begun to reveal exciting potential for them in normal lymphocyte biology and is launching a new phase of FCRL investigation. Importantly, these fundamental developments are also setting the stage for defining their altered roles in the pathogenesis of a growing number of immune-mediated diseases. Here we review recent advances in the FCRL field and highlight the significance of these intriguing receptors in normal and perturbed immunobiology.

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Acknowledgments

P.D.B. was supported by NIH grant AI100076. R.S.D. was supported by funding from the Lupus Research Institute, the UAB Center for AIDS Research (AI027767), and NIH grants AI097729, CA175912, and CA161731.

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Authors and Affiliations

  1. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    F. J. Li, W. J. Won, J. L. Easlick, E. M. Tabengwa, R. Li, M. Shakhmatov, K. Honjo  & R. S. Davis

  2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA

    E. J. Becker Jr., P. D. Burrows & R. S. Davis

  3. Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA

    R. S. Davis

  4. Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA

    P. D. Burrows

  5. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA

    P. D. Burrows & R. S. Davis

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  1. F. J. Li
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  2. W. J. Won
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  3. E. J. Becker Jr.
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  4. J. L. Easlick
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  5. E. M. Tabengwa
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  6. R. Li
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  7. M. Shakhmatov
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  8. K. Honjo
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  10. R. S. Davis
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Correspondence to R. S. Davis .

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Editors and Affiliations

  1. Institut Pasteur, Paris, France

    Marc Daeron

  2. Department of Biology, Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany

    Falk Nimmerjahn

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Li, F.J. et al. (2014). Emerging Roles for the FCRL Family Members in Lymphocyte Biology and Disease. In: Daeron, M., Nimmerjahn, F. (eds) Fc Receptors. Current Topics in Microbiology and Immunology, vol 382. Springer, Cham. https://doi.org/10.1007/978-3-319-07911-0_2

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