Advertisement

Cancer and Viruses

  • Milton W. TaylorEmail author
Chapter
  • 2k Downloads

Abstract

Cancer morbidity decreased in the last few years of the twentieth century, in large part due to early detection as well as the campaign against tobacco. The relationship between viruses and cancer, and the elaboration of the oncogene theory—from the early work on phage lambda and lysogeny—to oncogenes is presented. The majority of cancers result from somatic mutations and chromosomal rearrangements, which may cause proto-oncogene activation. Mutations in tumor suppressor genes also end in tumor formation. The function of these different genes is discussed, as are hereditary cancers. Viruses—such as papilloma, hepatitis C, hepatitis B, human herpes 8, Epstein-Barr virus and HTLV-1—induce cancers by varied mechanisms.

Keywords

Cervical Cancer Human Papilloma Virus Chronic Fatigue Syndrome Long Terminal Repeat Human Herpes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Knudson, A. G, Jr. (1974). Heredity and human cancer. American Journal of Pathology, 77(1), 77–84.PubMedCentralPubMedGoogle Scholar
  2. 2.
    Duesberg, P. (2007). Chromosomal chaos and cancer. Scientific American, 296(5), 52–59.PubMedCrossRefGoogle Scholar
  3. 3.
    Harris, H. (2008). Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. Preface. Journal of Cell Science, 121 Suppl 1, v–vi.PubMedCrossRefGoogle Scholar
  4. 4.
    Nakajima, H., Takaishi, M., Yamamoto, M., Kamijima, R., Kodama, H., Tarutani, M., et al. (2009). Screening of the specific polyoma virus as diagnostic and prognostic tools for Merkel cell carcinoma. Journal of Dermatological Science, 56(3), 211–213.PubMedCrossRefGoogle Scholar
  5. 5.
    Todaro, G. J., & Huebner, R. J. (1972). N.A.S. symposium: New evidence as the basis for increased efforts in cancer research. Proceedings of the National Academy of Sciences of the United States of America, 69(4), 1009–1015.PubMedCentralPubMedGoogle Scholar
  6. 6.
    Gross, L. (1974). Facts and theories on viruses causing cancer and leukemia. Proceedings of the National Academy of Sciences of the United States of America, 71(5), 2013–2017.PubMedCentralPubMedGoogle Scholar
  7. 7.
    Huebner, R. J., & Todaro, G. J. (1969). Oncogenes of RNA tumor viruses as determinants of cancer. Proceedings of the National Academy of Sciences of the United States of America, 64(3), 1087–1094.PubMedCentralPubMedGoogle Scholar
  8. 8.
    Rho, H. M., Poiesz, B., Ruscetti, F. W., & Gallo, R. C. (1981). Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology, 112(1), 355–360.PubMedCrossRefGoogle Scholar
  9. 9.
    Temin, H. M., & Mizutani, S. (1970). RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature, 226(5252), 1211–1213.PubMedCrossRefGoogle Scholar
  10. 10.
    Panet, A., Baltimore, D., & Hanafusa, T. (1975). Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay. Journal of Virology, 16(1), 146–152.PubMedCentralPubMedGoogle Scholar
  11. 11.
    Murray, M. J., Shilo, B. Z., Shih, C., Cowing, D., Hsu, H. W., & Weinberg, R. A. (1981). Three different human tumor cell lines contain different oncogenes. Cell, 25(2), 355–361.PubMedCrossRefGoogle Scholar
  12. 12.
    Easton, D. F. (1999). How many more breast cancer predisposition genes are there? Breast cancer research: BCR, 1(1), 14–17.PubMedCentralPubMedCrossRefGoogle Scholar
  13. 13.
    Campeau, P. M., Foulkes, W. D., & Tischkowitz, M. D. (2008). Hereditary breast cancer: new genetic developments, new therapeutic avenues. Human Genetics, 124(1), 31–42.PubMedCrossRefGoogle Scholar
  14. 14.
    Pal, T., Permuth-Wey, J., Betts, J. A., Krischer, J. P., Fiorica, J., Arango, H., et al. (2005). BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer, 104(12), 2807–2816.PubMedCrossRefGoogle Scholar
  15. 15.
    Lancaster, J. M., Carney, M. E., & Futreal, P. A. (1997). BRCA 1 and 2–A Genetic Link to Familial Breast and Ovarian Cancer. Medscape Womens Health, 2(2), 7.PubMedGoogle Scholar
  16. 16.
    Robson, M., Dabney, M. K., Rosenthal, G., Ludwig, S., Seltzer, M. H., Gilewski, T., et al. (1997). Prevalence of recurring BRCA mutations among Ashkenazi Jewish women with breast cancer. Genet Test, 1(1), 47–51.PubMedGoogle Scholar
  17. 17.
    Burkitt, D. P. (1983). The discovery of Burkitt’s lymphoma. Cancer, 51(10), 1777–1786.PubMedCrossRefGoogle Scholar
  18. 18.
    Gessain, A., Sudaka, A., Briere, J., Fouchard, N., Nicola, M. A., Rio, B., et al. (1996). Kaposi sarcoma-associated herpes-like virus (human herpes virus type 8) DNA sequences in multicentric Castleman’s disease: Is there any relevant association in non-human immunodeficiency virus-infected patients? Blood, 87(1), 414–416.PubMedGoogle Scholar
  19. 19.
    O’Neill, E., Henson, T. H., Ghorbani, A. J., Land, M. A., Webber, B. L., & Garcia, J. V. (1996). Herpes virus-like sequences are specifically found in Kaposi sarcoma lesions. Journal of Clinical Pathology, 49(4), 306–308.PubMedCentralPubMedCrossRefGoogle Scholar
  20. 20.
    Conjeevaram, H. S., Fried, M. W., Jeffers, L. J., Terrault, N. A., Wiley-Lucas, T. E., Afdhal, N., et al. (2006). Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology, 131(2), 470–477.PubMedCrossRefGoogle Scholar
  21. 21.
    Howell, C. D., Dowling, T. C., Paul, M., Wahed, A. S., Terrault, N. A., Taylor, M., et al. (2008). Peginterferon pharmacokinetics in African American and Caucasian American patients with hepatitis C virus genotype 1 infection. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, 6(5), 575–583.CrossRefGoogle Scholar
  22. 22.
    Abe, H., Hayes, C. N., Ochi, H., Maekawa, T., Tsuge, M., Miki, D., et al. (2011). IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy. Journal of Hepatology, 54(6), 1094–1101.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Indiana UniversityBloomingtonUSA

Personalised recommendations