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Poliovirus and Other Picornaviruses

  • Milton W. TaylorEmail author
Chapter
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Abstract

Poliovirus is an epidemic virus of the nineteenth and twentieth centuries. Although there were infections of polio in ancient times, the improvement in sanitation in the twentieth century led to epidemic outbreaks, particularly in western Europe and the U.S. Panic often accompanied outbreaks, particularly in the U.S., with demands for strict quarantine, prohibition of movement of people, and closing of places of recreation. Public interest in eradication of the virus led to fund-raising with the “March of Dimes,” whose aim was to alleviate suffering and develop a vaccine. The fact that President Roosevelt was a victim of polio helped with the campaign. The treatment of patients with polio was controversial; Sister Kenny claimed that exercise was important, while other physicians recommended rest. Patients were often kept in iron lungs for a long time. In 1955 the USPHS licensed an inactive virus vaccine, the Salk vaccine, which was used in mass vaccination of children in the U.S. Albert Sabin and Hilary Koprowski independently developed two attenuated viral vaccines, which were taken orally and replaced the Salk vaccine in the 1960s. Poliovirus belongs to the family of viruses known as picornavirus; this includes foot and mouth disease, which is of great economic importance and outbreaks of which have plagued the British cattle industry, and rhinoviruses—the common cold virus.

Keywords

National Foundation Scarlet Fever Warm Spring Television Personality Rockefeller Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Bollet, A. J. (2004). Plagues and Poxes. New York: Demos Medical Publishing, Inc.Google Scholar
  2. 2.
    Underwood, M. (1789). A treatise on the diseases of children with general directions on the management of infants from birth. London: John Churchill.Google Scholar
  3. 3.
    Axelsson, P. (2009). Do not eat those apples; they’ve been on the ground!: polio epidemics and preventive measures, Sweden 1880s–1940s. Asclepio; archivo iberoamericano de historia de la medicina y antropologia medica, 61(1), 23–38.PubMedGoogle Scholar
  4. 4.
    Grimshaw, M. L. (1995). Scientific specialization and the poliovirus controversy in the years before World War II. Bulletin of the History of Medicine, 69(1), 44–65.PubMedGoogle Scholar
  5. 5.
    Rhodes, J. (2013). The End of Plagues. United States: Palgrave, MacMillan.Google Scholar
  6. 6.
    Renne, E. P. (2011). The 1917 Polio Outbreak in Montpelier. Vermont. Vermont Historical Society Journal, 79, 162–181.Google Scholar
  7. 7.
    Oldstone M. B. A. (2010). Viruses, plagues and history. 2nd edn, Oxford: Oxford University Press.Google Scholar
  8. 8.
    Rogers, N. (2007). Race and the politics of polio: Warm springs, Tuskegee, and the March of Dimes. American Journal of Public Health, 97(5), 784–795.PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Oppewal, S. R. (1997). Sister Elizabeth Kenny, an Australian nurse, and treatment of poliomyelitis victims. Image–the Journal of Nursing Scholarship, 29(1), 83–87.PubMedGoogle Scholar
  10. 10.
    Golden, J., & Rogers, N. (2010). Nurse Irene Shea studies the “Kenny method” of treatment of infantile paralysis, 1942–1943. Nursing history review: official journal of the American Association for the History of Nursing, 18, 189–203.CrossRefGoogle Scholar
  11. 11.
    Bodian, D., Morgan, I. M., & Howe, H. A. (1949). Differentiation of types of poliomyelitis viruses; the grouping of 14 strains into three basic immunological types. American Journal of Hygiene, 49(2), 234–245.PubMedGoogle Scholar
  12. 12.
    Morgan, I. M. (1948). Immunization of monkeys with formalin-inactivated poliomyelitis viruses. American Journal of Hygiene, 48(3), 394–406.PubMedGoogle Scholar
  13. 13.
    Morgan, I. M. (1950). Persistence of neutralizing antibody for a year following vaccination of monkeys with Lansing poliomyelitis virus. Proceedings of the Society for Experimental Biology and Medicine, 75(2), 305–308.PubMedCrossRefGoogle Scholar
  14. 14.
    Koprowski, H. (1960). Historical aspects of the development of live virus vaccine in poliomyelitis. British Medical Journal, 2(5192), 85–91.PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Cello, J., Paul, A. V., & Wimmer, E. (2002). Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template. Science, 297(5583), 1016–1018.PubMedCrossRefGoogle Scholar
  16. 16.
    Franco, D., Pathak, H. B., Cameron, C. E., Rombaut, B., Wimmer, E., & Paul, A. V. (2005). Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. Journal of Virology, 79(10), 6358–6367.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Indiana UniversityBloomingtonUSA

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