The Predictability of Pharm-EEG in Patients with Long Unconscious Status
The main syndrome of severe poisoning is coma. An option of coma outcome is a vegetative state. EEG reactivity due to intravenous benzodiazepines estimates the prognosis for such patients. However, a positive benzodiazepines test has the predictability of about 50-60 %. The aim of the work is to assess the role of interaction between gamma amino butyric acid (GABA) and cholinergic systems of the brain. The consequent injections of benzodiazepine and atropine lead to a 20 % increase in predictability. The results obtained confirm the following hypothesis. Abnormality of GABA-cholinergic interaction is one of the mechanisms of forming a stable pathological system resulting in the pathogenesis of the vegetative state.
Keywordsacute poisoning neurotoxicity acute cerebral insufficiency EEG bioelectric activity
Unable to display preview. Download preview PDF.
- 3.Jennet, B.: The Vegetative State. Cambridge University Press, Cambridge (2002)Google Scholar
- 4.Kondrat’ev, A.N., Fadeeva, T.N., Kondrat’yeva, E.A.: Clinical and Electrophysiological Approaches to Diagnostics and Therapies of Patients in a Vegetative Status. Anesthesiology and Resuscitation 4, 47–50 (2003)Google Scholar
- 5.Laureys, S., Boly, M., Maquet, P.: Tracking the Recovery of Consciousness from Coma. J. Clin. Invest. 7, 1823–1825 (2006)Google Scholar
- 6.Niedermeyer, E., Lopes da Silwa, F.: Electroencephalography. Basis, Principles, Clinical Applications Related Fields. Lippincott Williams & Wilkins, Philadelphia, Baltimore, New York (2005)Google Scholar
- 8.Sofronov, G., Aleksandrov, M., Golovko, A., et al.: Emergency Toxicology. ELBY, Saint Petersburg (2012)Google Scholar