The Predictability of Pharm-EEG in Patients with Long Unconscious Status

  • Sergey Lytaev
  • Mikhail Aleksandrov
  • Sergey Vasilyev
  • Anna Arutunyan
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8534)


The main syndrome of severe poisoning is coma. An option of coma outcome is a vegetative state. EEG reactivity due to intravenous benzodiazepines estimates the prognosis for such patients. However, a positive benzodiazepines test has the predictability of about 50-60 %. The aim of the work is to assess the role of interaction between gamma amino butyric acid (GABA) and cholinergic systems of the brain. The consequent injections of benzodiazepine and atropine lead to a 20 % increase in predictability. The results obtained confirm the following hypothesis. Abnormality of GABA-cholinergic interaction is one of the mechanisms of forming a stable pathological system resulting in the pathogenesis of the vegetative state.


acute poisoning neurotoxicity acute cerebral insufficiency EEG bioelectric activity 


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Sergey Lytaev
    • 1
  • Mikhail Aleksandrov
    • 2
  • Sergey Vasilyev
    • 2
  • Anna Arutunyan
    • 2
  1. 1.Saint Petersburg State Pediatric Medical UniversityRussia
  2. 2.Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency MedicineRussia

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