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Introduction to Parasympathetic and Sympathetic Monitoring

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Clinical Autonomic Dysfunction

Abstract

This introductory section starts with a review of the “Old School” information commonly taught in medical school, including the anatomy of the autonomic nervous system (ANS) and its two branches, the parasympathetic and sympathetic nervous systems; the biochemistry of the ANS; general physiology associated with the two ANS branches; and methods of measuring the ANS. Measuring the ANS includes older noninvasive measures and the newer method to be the basis of this book. This section concludes by answering the “So What?” question behind the development of a newer method of measuring the ANS, specifically, a general introduction to why it is important to specifically measure the parasympathetic and sympathetic nervous systems, independently (in a mathematical sense) and simultaneously. The newer method removes many of the assumptions and approximations required by the older methods, improving specificity, sensitivity, reliability, and repeatability and thereby improving patient outcomes.

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References

  1. Robertson D, Bisggioni I, Burnstock G, Low PA, Paton JFR, editors. Primer on the autonomic nervous system. 3rd ed. Waltham: Academic; 2012.

    Google Scholar 

  2. The autonomic nervous system and the adrenal medulla. In: Text book of medical physiology, Guyton AC, Hall JE, editors. 11th ed. Philadelphia: WB Saunders; 2006.

    Google Scholar 

  3. Low PA, Engstrom JW. Disorders of the autonomic nervous system. In: Harrison’s Principles of Internal Medicine. 16th ed. New York: McGraw-Hill; 2003.

    Google Scholar 

  4. Saper CB. Autonomic disorders and their management. In: Cecil textbook of medicine. 22nd ed. Philadelphia: WB Saunders; 2003.

    Google Scholar 

  5. Goldstein DS. The autonomic nervous system in health and disease. New York: Marcel Dekker; 2001.

    Google Scholar 

  6. Mathias CJ, Bannister R. Autonomic failure: a textbook of clinical disorders of the autonomic nervous system. 5th ed. Oxford/New York: Oxford University Press; 2013.

    Book  Google Scholar 

  7. Akselrod S, Gordon S, Ubel FA, Shannon DC, Berger AC, Cohen RJ. Power spectrum analysis of heart rate fluctuations: a quantitative probe of beat-to- beat cardiovascular control. Science. 1981;213:213–20.

    Article  Google Scholar 

  8. Goldstein DS. Adrenaline and the inner world. Baltimore: The Johns Hopkins University Press; 2006.

    Google Scholar 

  9. Low PA, editor. Clinical autonomic disorders: evaluation and management. Philadelphia: Lippincott-Raven; 1997.

    Google Scholar 

  10. Gray MA, Rylander K, Harrison NA, Wallin BG, Critchley HD. Following one’s heart: cardiac rhythms gate central initiation of sympathetic reflexes. J Neurosci. 2009;29(6):1817–25.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Arora RR, Ghosh Dastidar S, Colombo J Autonomic balance is associated with decreased morbidity. American Autonomic Society, 17th International Symposium, Kauai, 29 Oct–1 Nov; 2008.

    Google Scholar 

  12. Waheed A, Ali MA, Jurivich DA, et al. Gender differences in longevity and autonomic function. Chicago: Geriatric Medicine Society Meeting; 2006.

    Google Scholar 

  13. Malik M. The Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability, standards of measurement, physiological interpretation, and clinical use. Circulation. 1996;93:1043–65.

    Article  Google Scholar 

  14. Malik M, Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability, standards of measurement, physiological interpretation, and clinical use. Eur Heart J. 1996;17:354–81.

    Article  Google Scholar 

  15. Vinik AI, Maser RE, Nakave AA. Diabetic cardiovascular autonomic nerve dysfunction. US Endocrine Disease. 2007;2:2–9.

    Google Scholar 

  16. Vinik A, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115:387–97.

    Article  PubMed  Google Scholar 

  17. Vinik AI, Aysin B, Colombo J. Enhanced frequency domain analysis identifies early autonomic dysfunction that may lead to elevated blood pressure in diabetics. San Francisco: Diabetes Technology Conference; 2005.

    Google Scholar 

  18. Low PA, Therapeutics and Technology Assessment Subcommittee Assessment. Clinical autonomic testing report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 1996;46:873–80.

    Google Scholar 

  19. American Diabetes Association; the National Heart, Lung, and Blood Institute; the Juvenile Diabetes Foundation International; the National Institute of Diabetes and Digestive and Kidney Diseases; and the American Heart Association. Diabetes mellitus: a major risk factor for cardiovascular disease. Circulation. 1999;100:1132–3.

    Article  Google Scholar 

  20. Grundy SM, Benjamin IJ, Burke GL, Chait A. AHA scientific statement: diabetes and cardiovascular disease, a statement for healthcare professionals from the American Heart Association. Circulation. 1999;100:1134–46.

    Article  CAS  PubMed  Google Scholar 

  21. Aring AM, Jones DE, Falko JM. Evaluation and prevention of diabetic neuropathy. Am Fam Phys. 2005;71:2123–30.

    Google Scholar 

  22. Boulton AJM, Vinik AI, Arrezzo JC, Bril V, Feldman EI, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956–62.

    Article  PubMed  Google Scholar 

  23. Tobias H, Vinitsky A, Bulgarelli RJ, Ghosh-Dastidar S, Colombo J. Autonomic nervous system monitoring of patients with excess parasympathetic responses to sympathetic challenges – clinical observations. US Neurol. 2010;5(2):62–6.

    Google Scholar 

  24. Umetani K, Singer DH, McCraty R, Atkinson M. Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. JACC. 1998;31(3):593–601.

    Article  CAS  PubMed  Google Scholar 

  25. Arora RR, Bulgarelli RJ, Ghosh-Dastidar S, Colombo J. Autonomic mechanisms and therapeutic implications of postural diabetic cardiovascular abnormalities. J Diabetes Sci Technol. 2008;2(4):568–71.

    Article  Google Scholar 

  26. Arora RR, Aysin E, Aysin B, Colombo J. Therapeutic implications of sympathetic stimulus in orthostatic patients: measured by spectral domain analysis. Orlando: AHA Scientific Sessions; 2007.

    Google Scholar 

  27. Curtis BM, O’Keefe JH. Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight or flight. Mayo Clin Proc. 2002;77:45–54.

    Article  PubMed  Google Scholar 

  28. Vinik AI, Murray GL. Autonomic neuropathy is treatable. US Endocrinol. 2008;2:82–4.

    Google Scholar 

  29. Nemechek P, Ghosh Dastidar S, Colombo J. Early autonomic dysfunction is associated with secondary hypertension in HIV/AIDS patients. St. Thomas: American Autonomic Society; 2009.

    Google Scholar 

  30. Nemechek P, Ghosh Dastidar S, Colombo J. HIV/AIDS leads to early cardiovascular autonomic neuropathy. St. Thomas: American Autonomic Society; 2009.

    Google Scholar 

  31. Arora RR, Bulgarelli RJ, Hearyman M, Ghosh Dastidar S, Colombo J. Carvedilol reverses standing parasympathetic excess in non-diabetics. St. Thomas: American Autonomic Society; 2009.

    Google Scholar 

  32. Nanavati SH, Bulgarelli RJ, Vazquez-Tanus J, Ghosh-Dastidar S, Colombo J, Arora RR. Altered autonomic activity with atrial fibrillation as demonstrated by non-invasive autonomic monitoring. US Cardiol. 2010;7(1):47–50.

    Google Scholar 

  33. Vinik AI, Aysin B, Colombo J. Differentiation of autonomic dysfunction by enhanced frequency domain analysis reveals additional stages in the progression of autonomic decline in diabetics. San Francisco: Diabetes Technology Conference; 2005.

    Google Scholar 

  34. Boyd GL, Taylor JA, Ovalle F, Stout DG, Aultman M, Garner VM, Morris RE, Witherspoon CD, Albert M, Vetter TR. Prevalence of advanced autonomic dysfunction in patients presenting for retinal surgery. Anesthesiology. 2013

    Google Scholar 

  35. Malik M, editor. Clinical guide to cardiac autonomic tests. Dordrecht: Kluwer Academic Publishers; 1998.

    Google Scholar 

  36. Tsuji H, Venditti Jr FJ, Manders ES, Evans JC, Larson MG, Feldman CL, Levy D. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation. 1994;90(2):878–83.

    Article  CAS  PubMed  Google Scholar 

  37. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care. 2003;26(5):1553–79.

    Article  PubMed  Google Scholar 

  38. Maser R, Mitchell B, Vinik AI, Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes, a meta analysis. Diabetes Care. 2003;26(6):1895–901.

    Article  PubMed  Google Scholar 

  39. DePace NL, Mears JP, Yayac M, Colombo J. Cardiac autonomic testing and diagnosing heart disease. “A clinical perspective.” Heart Int. 2013.

    Google Scholar 

  40. DePace NL, Mears JP, Yayac M, Colombo J. Cardiac autonomic testing and treating heart disease. “A clinical perspective.” Heart Int. 2013.

    Google Scholar 

  41. Bullinga JR, Alharethi R, Schram MS, Bristow MR, Gilbert EM. Changes in heart rate variability are correlated to hemodynamic improvement with chronic CARVEDILOL therapy in heart failure. J Card Fail. 2005;11(9):693–9.

    Article  CAS  PubMed  Google Scholar 

  42. Fatoni C, Raffa S, Regoli F, Giraldi F, La Rovere MT, Prentice J, Pastori F, Fratini S, Salerno-Uriarte JA, Klein HU, Auricchio A. Cardiac resynchronization therapy improves heart rate profile and heart rate variability of patients with moderate to severe heart failure. J Am Coll Cardiol. 2005;46(10):1875–82.

    Article  Google Scholar 

  43. Fathizadeh P, Shoemaker WC, Woo CCJ, Colombo J. Autonomic activity in trauma patients based on variability of heart rate and respiratory rate. Crit Care Med. 2004;32(5):1300–5.

    Article  PubMed  Google Scholar 

  44. Chen JY, Fung JW, Yu CM. The mechanisms of atrial fibrillation. J Cardiovasc Electrophysiol. 2006;17 Suppl 3:S2–7.

    Article  PubMed  Google Scholar 

  45. Copie X, Lamaison D, Salvador M, Sadoul N, DaCosta A, Faucher L, Legal F, Le Heuzey JY, VALID Investigators. Heart rate variability before ventricular arrhythmias in patients with coronary artery disease and an implantable cardioverter defibrillator. Ann Noninvasive Electrocardiol. 2003;8(3):179–84.

    Google Scholar 

  46. Alter P, Grimm W, Vollrath A, Czerny F, Maisch B. Heart rate variability in patients with cardiac hypertrophy–relation to left ventricular mass and etiology. Am Heart J. 2006;151(4):829–36.

    Article  PubMed  Google Scholar 

  47. Debono M, Cachia E. The impact of cardiovascular autonomic neuropathy in diabetes: is it associated with left ventricular dysfunction? Auton Neurosci. 2007;132(1–2):1–7.

    Article  PubMed  Google Scholar 

  48. Just H. Peripheral adaptations in congestive heart failure: a review. Am J Med. 1991;90:23S–6.

    Article  CAS  PubMed  Google Scholar 

  49. Nakamura K, Matsumura K, Kobayashi S, Kaneko T. Sympathetic premotor neurons mediating thermoregulatory functions. Neurosci Res. 2005;51(1):1–8.

    Article  PubMed  Google Scholar 

  50. Manfrini O, Morgagni G, Pizzi C, Fontana F, Bugiardini R. Changes in autonomic nervous system activity: spontaneous versus balloon-induced myocardial ischaemia. Eur Heart J. 2004;25(17):1502–8.

    Article  PubMed  Google Scholar 

  51. Clarke B, Ewing D, Campbell I. Diabetic autonomic neuropathy. Diabetologia. 1979;17:195–212.

    Article  CAS  PubMed  Google Scholar 

  52. Arora RR, Iffrig K, Colombo J. Geriatric female longevity associated with elevated parasympathetic tone. Can the same be affected in geriatric males? Rio Grande: Presented at the American Autonomic Society’s 17th International Symposium on the Autonomic Nervous System; 2006.

    Google Scholar 

  53. Litchman JH, Bigger Jr JT, Blumenthal JA, et al. Depression and coronary heart disease recommendations for screening, referral, and treatment: A science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation. 2008;118:1768–75.

    Article  Google Scholar 

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Colombo, J., Arora, R., DePace, N.L., Vinik, A.I. (2015). Introduction to Parasympathetic and Sympathetic Monitoring. In: Clinical Autonomic Dysfunction. Springer, Cham. https://doi.org/10.1007/978-3-319-07371-2_1

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  • DOI: https://doi.org/10.1007/978-3-319-07371-2_1

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