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Neuropathy Associated with Endocrine and Metabolic Disease

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Biopsy Diagnosis of Peripheral Neuropathy

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Abstract

Endocrine and metabolic disturbances are probably the most common causes of neuropathy (Table 17.1). In these situations, the diagnosis is based on clinical and laboratory findings, examination of peripheral nerve biopsy having no role in management. Nevertheless, the pathologist should be aware of the spectrum of pathology seen in each entity, as biopsy may be performed in such patients on the suspicion that another pathological process is at play. Toxic neuropathies other than alcohol are considered separately in Chap. 18.

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References

  • Abarbanel JM, Frisher S, Osimani A (1986) Vitamin B12 deficiency neuropathy: sural nerve biopsy study. Isr J Med Sci 22:909–911

    CAS  PubMed  Google Scholar 

  • Ahonen RE (1981) Peripheral neuropathy in uremic patients and in renal transplant recipients. Acta Neuropathol 54:43–53

    CAS  PubMed  Google Scholar 

  • Alderson K (1992) Axonal swellings in human intramuscular nerves. Muscle Nerve 15:1284–1289

    CAS  PubMed  Google Scholar 

  • Appenzeller O, Kornfeld M, MacGee J (1971) Neuropathy in chronic renal disease. Arch Neurol 24:449–461

    CAS  PubMed  Google Scholar 

  • Archer A, Watkins PJ, Thomas PK et al (1983) The natural history of acute painful neuropathy in diabetes mellitus. J Neurol Neurosurg Psychiatry 46:491–499

    CAS  PubMed Central  PubMed  Google Scholar 

  • Arnold R, Kwai NCG, Krishnan AV (2013) Mechanisms of axonal dysfunction in diabetic and uraemic neuropathies. Clin Neurophysiol 124:2079–2090

    PubMed  Google Scholar 

  • Asbury AK, Victor M, Adams RD (1963) Uremic polyneuropathy. Arch Neurol 8:413–428

    CAS  PubMed  Google Scholar 

  • Ballin RHM, Thomas PK (1968) Hypertrophic changes in diabetic neuropathy. Acta Neuropathol 11:93–102

    CAS  PubMed  Google Scholar 

  • Barohn RJ, Sahenk Z, Warmolts JR, Mendell JR (1991) The Bruns-Garland syndrome (diabetic amyotrophy). Revisited 100 years later. Arch Neurol 48:1130–1135

    CAS  PubMed  Google Scholar 

  • Bastron JA, Thomas JE (1981) Diabetic polyradiculopathy. Clinical and electromyographic findings in 105 patients. Mayo Clin Proc 56:725–732

    CAS  PubMed  Google Scholar 

  • Baumgaertel MW, Kraemer M, Berlit P (2014) Chapter 24. Neurologic complications of acute and chronic renal disease. In: Biller J, Ferro JM (eds) Neurologic aspects of systemic disease part I, vol 119 (3rd series), Handbook of clinical neurology. Elsevier BV, Amsterdam, pp 383–393

    Google Scholar 

  • Becker DA, Balcer LJ, Galetta SL (2012) The neurological complications of nutritional deficiency following bariatric surgery. J Obesity http://dx.doi.org/10.1155/2012/608534

  • Behse F, Buchthal F (1977) Alcoholic neuropathy: clinical, electrophysiological and biopsy findings. Ann Neurol 2:95–110

    Google Scholar 

  • Behse F, Buchthal F, Carlsen F (1977) Nerve biopsy and conduction studies in diabetic neuropathy. J Neurol Neurosurg Psychiatry 40:1072–1082

    CAS  PubMed Central  PubMed  Google Scholar 

  • Berger JR, Ayyar DR, Sheremata WA (1981) Guillain-Barre syndrome complicating acute hepatitis B. Arch Neurol 38:366–368

    CAS  PubMed  Google Scholar 

  • Berlit P, Mahlberg U, Usadel KH (1992) Polyneuropathy in hyperthyroidism-a clinical neurophysiologic study. Schweiz Arch Neurol Psychiatr 143:81 (abstr.)

    CAS  PubMed  Google Scholar 

  • Bird SJ, Brown MJ (1996) The clinical spectrum of diabetic neuropathy. Semin Neurol 16:115–122

    CAS  PubMed  Google Scholar 

  • Bischoff A, Lutschg J, Meier CL (1975) Polyneuropathie bei vitamin-B12 und folsauremangel. Med Wochenschr 117:1593–1598

    CAS  Google Scholar 

  • Blass JP, Gibson GE (1977) Abnormality of a thiamine requiring enzyme in patients with Wernicke Korsakoff syndrome. N Engl J Med 297:1367–1370

    CAS  PubMed  Google Scholar 

  • Bolton CF, Young GB (1990) Neurologic complications of renal disease. Butterworth, Stoneham

    Google Scholar 

  • Bosch EP, Pecham RW, Rascol CG et al (1979) Animal models of alcoholic neuropathy: morphologic, electrophysiologic, and biochemical findings. Muscle Nerve 2:133–144

    CAS  PubMed  Google Scholar 

  • Botez MI, Peyronnard JM, Bachevalier J, Charron L (1978) Polyneuropathy and folate deficiency. Arch Neurol 35:581–584

    CAS  PubMed  Google Scholar 

  • Bradley J, Thomas PK, King RHM et al (1990) Morphometry of endoneurial capillaries in diabetic sensory neuropathy. Diabetologia 33:611–618

    CAS  PubMed  Google Scholar 

  • Brewster WJ, Diemel LT, Leach RM, Tomlinson DR (1994) Reduced sciatic nerve substance P and calcitonin gene-related peptide in rats with short-term diabetes or central hypoxaemia co-exist with normal messenger RNA levels in the lumbar dorsal root ganglia. Neuroscience 58:323–330

    CAS  PubMed  Google Scholar 

  • Brown MJ, Martin JR, Asbury AK (1976) Painful diabetic neuropathy: a morphometric study. Arch Neurol 33:164–171

    CAS  PubMed  Google Scholar 

  • Burn DJ, Bates D (1998) Neurology and the kidney. J Neurol Neurosurg Psychiatry. 65:810–821

    CAS  PubMed Central  PubMed  Google Scholar 

  • Callizot N, Warter JM, Poindron P (2001) Pyridoxine-induced neuropathy in rats: a sensory neuropathy that responds to 4-methylcatechol. Neurobiol Dis 8:626–635

    CAS  PubMed  Google Scholar 

  • Campanucci V, Krishnaswamy A, Cooper E (2010) Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nACHRs through a conserved intracellular cysteine residue. Neuron 66:827–834

    CAS  PubMed  Google Scholar 

  • Chari VR, Katiyar BC, Rastogi BL, Bhattacharya SK (1977) Neuropathy in hepatic disorders: a clinical, electrophysiological and histopathological appraisal. J Neurol Sci 31:93–111

    CAS  PubMed  Google Scholar 

  • Charron L, Peyronnard JM, Marchand L (1980) Sensory neuropathy associated with primary biliary cirrhosis. Ann Neurol 37:84–87

    CAS  Google Scholar 

  • Cheng C, Zochodne DW (2003) Sensory neurons with activated caspase-3 survive long-term experimental diabetes. Diabetes 52:2363–2371

    CAS  PubMed  Google Scholar 

  • Cheng HT, Dauch JR, Porzio MT et al (2013) Increased axonal regeneration and swellings in intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathy. J Pain 14:941–947

    PubMed Central  PubMed  Google Scholar 

  • Choi J, Chandrasekaran K, Inoue T et al (2014) PGC-1alpha regulation of mitochondrial degeneration in experimental diabetic neuropathy. Neurobiol Dis 64C:118–130

    Google Scholar 

  • Chopra JS, Hurwitz LJ, Montgomery DAD (1969) The pathogenesis of sural nerve changes in diabetes mellitus. Brain 92:391–418

    CAS  PubMed  Google Scholar 

  • Chowdhury SKR, Zherebitskaya E, Smith DR et al (2010) Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes 59:1082–1091

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chowdhury SKR, Dobrowsky RT, Fernyhough P (2011) Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes. Mitochondrion 11:845–854

    CAS  PubMed  Google Scholar 

  • Chowdhury SKR, Smith DR, Saleh A (2012) Impaired adenosine monophosphate-activated protein kinase signaling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes. Brain 135:1751–1766

    Google Scholar 

  • Chowdhury SKR, Smith DR, Fernyhough P (2013) The role of aberrant mitochondrial bioenergetics in diabetic neuropathy. Neurobiol Dis 51:56–65

    CAS  PubMed  Google Scholar 

  • Claus D, Eggers R, Engelhardt A et al (1985) Ethanol and polyneuropathy. Acta Neurol Scand 72:312–326

    CAS  PubMed  Google Scholar 

  • Coers C, Woolf AL (1959) The innervation of muscle. A biopsy study. Charles C. Thomas, Springfield, p 91

    Google Scholar 

  • Collins GH, Websterhde F, Victor M (1964) The ultrastructure of myelin and axonal alterations in sciatic nerves of thiamine deficient and starving rats. Acta Neuropathol 3:511–521

    CAS  PubMed  Google Scholar 

  • Committee on Health Care Issues, American Neurological Association (1986) Does improved control of glycemia prevent or ameliorate diabetic polyneuropathy? Ann Neurol 19:288–290

    Google Scholar 

  • Costigan DA, Krendel DA, Hopkins LC, Crittenden J (1990) Inflammatory neuropathy in diabetes. Ann Neurol 28:272 (abstr.)

    Google Scholar 

  • D’Amour ML, Bruneau J, Butterworth RF (1991) Abnormalities of peripheral nerve conduction in relation to thiamine status in alcoholic patients. Can J Neurol Sci 18:126–128

    PubMed  Google Scholar 

  • Dayan AD, Williams R (1967) Demyelinating peripheral neuropathy and liver disease. Lancet 2:133–134

    CAS  PubMed  Google Scholar 

  • Dayan AD, Gardner-Thorpe C, Down PF, Gleadle RI (1970) Peripheral neuropathy in uremia. Neurology 20:649–658

    CAS  PubMed  Google Scholar 

  • DCCT (Diabetes Control and Complications Trial) Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977–986

    Google Scholar 

  • Dey I, Midha N, Singh G et al (2013) Diabetic Schwann cells suffer from nerve growth factor and neurotrophin-3 underproduction and poor associability with axons. Glia 61:1990–1999

    PubMed  Google Scholar 

  • Dinn JJ, Crane DL (1970) Schwann cell dysfunction in uraemia. J Neurol Neurosurg Psychiatry 33:605–608

    CAS  PubMed Central  PubMed  Google Scholar 

  • Dinn JJ, Dinn EI (1985) Natural history of acromegalic peripheral neuropathy. Q J Med 57:833–842

    CAS  PubMed  Google Scholar 

  • Djoenaidi W, Notemrans SL (1990) Electrophysiologic evaluation of beri-beri polyneuropathy. Electromyogr Clin Neurophysiol 30:97–103

    CAS  PubMed  Google Scholar 

  • Dyck PJ (1989) Hypoxic neuropathy: does hypoxia play a role in diabetic neuropathy? The 1988 Robert Wartenberg Lecture. Neurology 39:111–118

    CAS  PubMed  Google Scholar 

  • Dyck PJ, Lambert EH (1970) Polyneuropathy associated with hypothyroidism. J Neuropathol Exp Neurol 29:631–658

    CAS  PubMed  Google Scholar 

  • Dyck PJ, Johnson WJ, Lambert EH, O’Brien PC (1971) Segmental demyelination secondary to axonal degeneration in uremic neuropathy. Mayo Clin Proc 46:400–431

    CAS  PubMed  Google Scholar 

  • Dyck PJ, Sherman WR, Hallcher LM et al (1980) Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry. Ann Neurol 8:590–596

    CAS  PubMed  Google Scholar 

  • Dyck PJ, Hansen S, Karnes J et al (1985) Capillary number and percentage closed in human diabetic sural nerve. Proc Natl Acad Sci U S A 82:2513–2517

    CAS  PubMed Central  PubMed  Google Scholar 

  • Dyck PJ, Karnes JL, O’Brien P et al (1986a) The spatial distribution of fiber loss in diabetic polyneuropathy suggests ischemia. Ann Neurol 19:440–449

    CAS  PubMed  Google Scholar 

  • Dyck PJ, Lais A, Karnes JL et al (1986b) Fiber loss is primary and multifocal in sural nerves in diabetic polyneuropathy. Ann Neurol 19:425–439

    CAS  PubMed  Google Scholar 

  • Dyck PJ, Kratz KM, Karnes JL et al (1993) The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population based cohort: the Rochester Diabetic Neuropathy Study. Neurology 43:817–824

    CAS  PubMed  Google Scholar 

  • Dyck PJB, Novell JE, Dyck PJ (1999) Microvasculitis and ischemia in diabetic lumbosacral radiculopexus neuropathy. Neurology 53:2113–2121

    CAS  PubMed  Google Scholar 

  • Ekberg K, Brismar T, Johansson BL et al (2003) Amelioration of sensory nerve dysfunction by C-peptide in patients with type 1 diabetes. Diabetes 52:536–541

    CAS  PubMed  Google Scholar 

  • Ekstrom AR, Kanje M, Skottner A (1989) Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency. Brain Res 496:141–147

    CAS  PubMed  Google Scholar 

  • Ewing DJ, Campbell IW, Clarke BF (1980) The natural history of diabetic autonomic neuropathy. Q J Med 49:95–108

    CAS  PubMed  Google Scholar 

  • Fehling C, Jagerstad M, Lindstrand K, Elmqvist D (1974) Folate deficiency and neurological disease. Arch Neurol 30:263–265

    CAS  PubMed  Google Scholar 

  • Feibel JH, Campa JF (1976) Thyrotoxic neuropathy (Basedow’s paraplegia). J Neurol Neurosurg Psychiatry 39:491–497

    CAS  PubMed Central  PubMed  Google Scholar 

  • Fernyhough P, Huang TJ, Verkhratsky A (2003) Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy. J Peripher Nerv Syst 8:227–235

    PubMed  Google Scholar 

  • Frasca V, Riazza BS, Matthews RG (1986) In vivo inactivation of methionine synthase by nitrous oxide. J Biol Chem 261: 15823–15826

    CAS  PubMed  Google Scholar 

  • Giannini C, Dyck PJ (1995) Basement membrane reduplication and pericyte degeneration precede development of diabetic polyneuropathy and are associated with its severity. Ann Neurol 37:498–504

    CAS  PubMed  Google Scholar 

  • Gotoda T, Arita M, Arai H et al (1995) Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer protein. N Engl J Med 333:1313–1318

    CAS  PubMed  Google Scholar 

  • Granberg V, Ejskjaer N, Peakman M, Sundkvist G (2005) Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy. Diabetes Care 28:1959–1964

    PubMed  Google Scholar 

  • Greenfield JG, Carmichael EA (1935) The peripheral nerves in cases of subacute combined degeneration of the cord. Brain 58:483–491

    Google Scholar 

  • Griffey RH, Eaton RP, Sibbitt RR et al (1988) Diabetic neuropathy: structural analysis of nerve hydration by magnetic resonance spectroscopy. JAMA 260:2872–2878

    CAS  PubMed  Google Scholar 

  • Hallett M, Fox JG, Rogers AE et al (1987) Controlled studies on the effects of alcohol ingestion on peripheral nerves of macaque monkeys. J Neurol Sci 80:65–71

    CAS  PubMed  Google Scholar 

  • Hammond N, Wang Y, Dimachkie MM et al (2013) Nutritional neuropathies. Neurol Clin 31:477–489

    PubMed Central  PubMed  Google Scholar 

  • Harati Y (1992) Frequently asked questions about diabetic peripheral neuropathies. Neurol Clin 10:783–807

    CAS  PubMed  Google Scholar 

  • Hellweg R, Hartung HD (1990) Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: a possible role for NGF in the pathogenesis of diabetic neuropathy. J Neurosci Res 26:258–267

    CAS  PubMed  Google Scholar 

  • Igata A (1984) Beriberi in Asian countries. In Sobue I (ed) Peripheral neuropathy. Proceedings of the international symposium on peripheral neuropathy. Excerpta Medica, Amsterdam, p 247–256

    Google Scholar 

  • Illa I, Graus F, Ferrer I, Enriquez J (1989) Sensory neuropathy as the initial manifestation of primary biliary cirrhosis. J Neurol Neurosurg Psychiatry 52:1307

    CAS  PubMed Central  PubMed  Google Scholar 

  • Inoue AN, Tsukada N, Koh CS, Yanagisawa N (1987) Chronic relapsing demyelinating polyneuropathy associated with hepatitis B infection. Neurology 37:1663–1666

    CAS  PubMed  Google Scholar 

  • Ishii DN (1993) Insulin and related neurotrophic factors in diabetic neuropathy. Diabet Med 10(Suppl 2):14S–15S

    PubMed  Google Scholar 

  • Jamal GA, Kerr DJ, McLellan AR et al (1987) Generalized peripheral nerve dysfunction in acromegaly: a study by conventional and novel neurophysiological techniques. J Neurol Neurosurg Psychiatry 50:886–894

    CAS  PubMed Central  PubMed  Google Scholar 

  • Johnson PC, Brendel K, Meezan E (1981) Human diabetic perineurial cell basement membrane thickening. Lab Invest 44:265–270

    CAS  PubMed  Google Scholar 

  • Johnson PC, Doll SC, Cromey W (1986) Pathogenesis of diabetic neuropathy. Ann Neurol 19:450–457

    CAS  PubMed  Google Scholar 

  • Juranek JK, Kothary P, Mehra A et al (2013) Increased expression of the receptor for advanced glycation end-products in human peripheral neuropathies. Brain Behav 3:701–709

    PubMed Central  PubMed  Google Scholar 

  • Kalichman M, Myers R (1991) Transperineurial vessel constriction in an edematous neuropathy. J Neuropathol Exp Neurol 50:408–418

    CAS  PubMed  Google Scholar 

  • Kardel T, Nielsen VK (1974) Hepatic neuropathy: a clinical and electrophysiological study. Acta Neurol Scand 50:513–526

    CAS  PubMed  Google Scholar 

  • Kelkar P, Hammer-White S (2005) Impaired glucose tolerance in nondiabetic lumbosacral radiculoplexus neuropathy. Muscle Nerve 31:273–274

    PubMed  Google Scholar 

  • Kennedy WR (2004) Opportunities afforded by the study of unmyelinated nerves in skin and other organs. Muscle Nerve 29:756–767

    PubMed  Google Scholar 

  • Kennedy JM, Zochodne DW (2005) Experimental diabetic neuropathy with spontaneous recovery: is there irreparable damage? Diabetes 54:830–837

    CAS  PubMed  Google Scholar 

  • Kim B, Feldman EL (2012) Insulin resistance in the nervous system. Trends Endocrinol Metab 23:133–141

    CAS  PubMed Central  PubMed  Google Scholar 

  • King RHM, Llewelyn JG, Thomas PK et al (1989) Diabetic neuropathy: abnormalities of Schwann cell and perineurial basal lamiae. Implications for diabetic vasculopathy. Neuropathol Appl Neurobiol 15:339–355

    CAS  PubMed  Google Scholar 

  • Knill-Jones RP, Goodwill CJ, Dayan AD, Williams R (1972) Peripheral neuropathy in chronic liver disease: clinical, electrodiagnostic, and nerve biopsy findings. J Neurol Neurosurg Psychiatry 35:22–30

    CAS  PubMed Central  PubMed  Google Scholar 

  • Koike H, Sobue G (2006) Alcoholic neuropathy. Curr Opin Neurol 19:481–486

    CAS  PubMed  Google Scholar 

  • Koike H, Iijima M, Sugiura M et al (2003) Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol 54:19–29

    PubMed  Google Scholar 

  • Kosik KS, Mullins TS, Bradley WG et al (1980) Coma and axonal degeneration in vitamin B12 deficiency. Arch Neurol 37:590–592

    CAS  PubMed  Google Scholar 

  • Krinke G, Naylor DC, Skorpil V (1985) Pyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neurons. J Neuropathol Exp Neurol 44:117–129

    CAS  PubMed  Google Scholar 

  • Krishnan AV, Kiernan MC (2007) Uremic neuropathy: clinical features and new pathophysiological insights. Muscle Nerve 35:273–290

    CAS  PubMed  Google Scholar 

  • Laplante P, Vanasse M, Michaud J et al (1984) A progressive neurological syndrome associated with an isolated vitamin E deficiency. Can J Neurol Sci 11:561–564

    CAS  PubMed  Google Scholar 

  • Lauria G, Cornblath DR, Johansson O et al (2005) EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 12:747–758

    CAS  PubMed  Google Scholar 

  • Llewelyn JG, Thomas PK, Fonseca V et al (1986) Acute painful diabetic neuropathy precipitated by strict glycaemic control. Acta Neuropathol 72:157–163

    CAS  PubMed  Google Scholar 

  • Llewelyn JG, Thomas PK, Gilbey SG et al (1988) Pattern of myelinated fibre loss in the sural nerve in neuropathy related to type 1 (insulin-dependent) diabetes. Diabetologia 31:162–167

    CAS  PubMed  Google Scholar 

  • Llewelyn JG, Gilbey SG, Thomas PK et al (1991) Sural nerve morphometry in diabetic autonomic and painful sensory neuropathy: a clinicopathological study. Brain 114:867–892

    PubMed  Google Scholar 

  • Llewelyn JG, Thomas PK, King RH (1998) Epineurial microvasculitis in proximal diabetic neuropathy. J Neurol 245:159–165

    CAS  PubMed  Google Scholar 

  • Llewelyn J, Tomlinson D, Thomas P (2005) Diabetic neuropathies. In: Dyck P, Thomas P (eds) Peripheral neuropathy. Elsevier-Saunders, Philadelphia, pp 1951–1991

    Google Scholar 

  • Longo FM, Powell HC, Lebeau J et al (1986) Delayed nerve regeneration in streptozotocin diabetic rats. Muscle Nerve 9:385–393

    CAS  PubMed  Google Scholar 

  • Lossos A, Argov Z, Ackerman Z, Abramsky O (1991) Peripheral neuropathy with folate deficiency as the first sign of Crohn’s disease. J Clin Gastroenterol 13:442–444

    CAS  PubMed  Google Scholar 

  • Low PA, McLeod JG, Turtle JR et al (1974) Peripheral neuropathy in acromegaly. Brain 97:139–152

    CAS  PubMed  Google Scholar 

  • Ludin HP, Spiess H, Koenig MP (1969) Neuropathie et hyperthyreose. Rev Neurol 120:424–426

    CAS  PubMed  Google Scholar 

  • Ludwig J, Dyck PJ, LaRusso NG (1982) Xanthomatous neuropathy of liver. Hum Pathol 13:1049–1051

    CAS  PubMed  Google Scholar 

  • Luo KR, Chao CC, Chen YT et al (2011) Quantitation of sudomotor innervation in skin biopsies of patients with diabetic neuropathy. J Neuropathol Exp Neurol 70:930–938

    PubMed  Google Scholar 

  • Malatova Z, Cizkova D (2002) Effect of ethanol on axonal transport of cholinergic enzymes in rat sciatic nerve. Alcohol 26:115–120

    CAS  PubMed  Google Scholar 

  • Malik RA, Newrick PG, Sharma AK et al (1989) Microangiopathy in human diabetic neuropathy: relationship between capillary abnormalities and the severity of neuropathy. Diabetologia 32:92–102

    CAS  PubMed  Google Scholar 

  • Malik RA, Tesfaye S, Thompson SD et al (1993) Endoneurial localization of microvascular damage in human diabetic neuropathy. Diabetologia 36:454–459

    CAS  PubMed  Google Scholar 

  • Masaki T, Mochizuki H, Matsushita S et al (2004) Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans. Neurosci Lett 363:288–290

    CAS  PubMed  Google Scholar 

  • McCarthy BG, Hsieh ST, Stocks A et al (1995) Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 45:1848–1855

    CAS  PubMed  Google Scholar 

  • McCombe PA, McLeod JG (1984) The peripheral neuropathy of vitamin B12 deficiency. J Neurol Sci 66:117–126

    CAS  PubMed  Google Scholar 

  • McLane JA (1987) Decreased axonal transport in rat nerve following acute and chronic ethanol exposure. Alcohol 4:385–389

    CAS  PubMed  Google Scholar 

  • Meier C, Bischoff A (1977) Polyneuropathy in hypothyroidism. Clinical and nerve biopsy study of 4 cases. J Neurol 215:103–114

    CAS  PubMed  Google Scholar 

  • Molitch ME (1992) Clinical manifestations of Acromegaly. Endocrinol Metab Clin North Am 21:597–614

    CAS  PubMed  Google Scholar 

  • Muller DP, Goss-Sampson MA (1990) Neurochemical, neurophysiological, and neuropathological studies in vitamin E deficiency. Crit Rev Neurobiol 5:239–263

    CAS  PubMed  Google Scholar 

  • Nemni R, Bottacchi E, Fazio R et al (1987) Polyneuropathy in hypothyroidism: clinical, electrophysiological, and morphological findings in four cases. J Neurol Neurosurg Psychiatry 50:1454–1460

    CAS  PubMed Central  PubMed  Google Scholar 

  • Nickel SN, Frame B, Bebin J et al (1961) Myxedema neuropathy and myopathy: a clinical and pathologic study. Neurology 11:125–137

    CAS  PubMed  Google Scholar 

  • Niermeijer P, Gips CH (1975) Guillain-Barre syndrome in acute HBS Ag-positive hepatitis. Br Med J 4:732–733

    CAS  PubMed Central  PubMed  Google Scholar 

  • Novella SP, Inzucchi SE, Goldstein JM (2001) The frequency of undiagnosed diabetes and impaired glucose tolerance in patients with idiopathic sensory neuropathy. Muscle Nerve 24:1229–1231

    CAS  PubMed  Google Scholar 

  • O’Brien PD, Hinder LM, Sakowski SA et al (2014) ER stress in diabetic peripheral neuropathy: a new therapeutic target. Antioxid Redox Signal. doi:10.1089/ars.2013.5807

    PubMed  Google Scholar 

  • Obrosova IG (2002) How does glucose generate oxidative stress in peripheral nerve? Int Rev Neurobiol 50:3–35

    CAS  PubMed  Google Scholar 

  • Obrosova IG (2009) Diabetes and the peripheral nerve. Biochim Biophys Acta 1792:931–940

    CAS  PubMed  Google Scholar 

  • Ochoa J (1970) Isoniazid neuropathy in man: quantitative electron microscope study. Brain 93:831–850

    CAS  PubMed  Google Scholar 

  • Ohnishi A, Tsuji S, Igisu H et al (1980) Beriberi neuropathy. Morphometric study of sural nerve. J Neurol Sci 45:177–190

    CAS  PubMed  Google Scholar 

  • Osuntokun BO (1980) Neuroepidemiology in Africa. In: Rose FC (ed) Clinical neuroepidemiology. Pitman Medical LTD, Kent, pp 57–86

    Google Scholar 

  • Paladin F, Russo Perez G (1987) The haematic thiamine level in the course of alcoholic neuropathy. Eur Neurol 26:129–133

    CAS  PubMed  Google Scholar 

  • Parry TE (1990) Folate deficient neuropathy. Acta Haematol 84:108

    CAS  PubMed  Google Scholar 

  • Peltier AC, Myers MI, Artibee KJ et al (2013) Evaluation of dermal myelinated nerve fibers in diabetes mellitus. J Peripher Nerv Syst 18:162–167

    PubMed  Google Scholar 

  • Periquet MI, Novak V, Collins MP et al (1999) Painful sensory neuropathy: prospective evaluation using skin biopsy. Neurology 53:1641–1647

    CAS  PubMed  Google Scholar 

  • Pickett JBE, Layzer RB, Levin SR et al (1975) Neuromuscular complications of acromegaly. Neurology 25:638–645

    CAS  PubMed  Google Scholar 

  • Pierson CR, Zhang W, Murakawa Y, Sima AA (2002) Early gene responses of trophic factors in nerve regeneration differ in experimental type 1 and type 2 diabetic polyneuropathies. J Neuropathol Exp Neurol 61:857–871

    CAS  PubMed  Google Scholar 

  • Pierson CR, Zhang W, Sima AA (2003a) Proinsulin C-peptide replacement in type 1 diabetic BB/Wor-rats prevents deficits in nerve fiber regeneration. J Neuropathol Exp Neurol 62:765–779

    CAS  PubMed  Google Scholar 

  • Pierson CR, Zhang W, Murakawa Y, Sima AA (2003b) Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy. J Neuropathol Exp Neurol 62:260–271

    CAS  PubMed  Google Scholar 

  • Pirart J (1978a) Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Part 1. Diabetes Care 1:168–188

    Google Scholar 

  • Pirart J (1978b) Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Part 2. Diabetes Care 1:252–263

    Google Scholar 

  • Pollard JD, McLeod JG, Honnibal TG, Verheijden MA (1982) Hypothyroid polyneuropathy. Clinical, electrophysiological and nerve biopsy findings in two cases. J Neurol Sci 53:461–471

    CAS  PubMed  Google Scholar 

  • Poupon RE, Gervaise G, Riant P et al (1990) Blood thiamine and thiamine phosphate concentrations in excessive drinkers with or without peripheral neuropathy. Alcohol Alcohol 25:605–611

    CAS  PubMed  Google Scholar 

  • Prasnoor M, Dimachkie MM, Barohn RJ (2013) Diabetic neuropathy part 2 proximal and asymmetric phenotypes. Neurol Clin 31:447–462

    Google Scholar 

  • Purves T, Middlemas A, Agthong S et al (2001) A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy. FASEB J 15:2508–2514

    CAS  PubMed  Google Scholar 

  • Rabinowe SL, Brown FM, Watts M, Smith AM (1990) Complement-fixing antibodies to sympathetic and parasympathetic tissues in IDDM: autonomic brake index and heart-rate variation. Diabetes Care 13:1084–1088

    CAS  PubMed  Google Scholar 

  • Raff MC, Sangalang V, Asbury AK (1968) Ischemic mononeuropathy multiplex associated with diabetes mellitus. Arch Neurol 18:487–499

    CAS  PubMed  Google Scholar 

  • Raskin NH, Fishman RA (1965) Pyridoxine-deficiency neuropathy due to hydralazine. N Engl J Med 273:1182–1185

    CAS  PubMed  Google Scholar 

  • Ropper AH (1993) Accelerated neuropathy of renal failure. Arch Neurol 50:536–539

    CAS  PubMed  Google Scholar 

  • Rosenblum JL, Keating JP, Prensky AL, Nelson JS (1981) A progressive neurologic syndrome in children with chronic liver disease. N Engl J Med 304:503–508

    CAS  PubMed  Google Scholar 

  • Rundles R (1945) Diabetic neuropathy: general review with report of 125 cases. Medicine 24:111–160

    Google Scholar 

  • Russell JW, Sullivan KA, Windebank AJ et al (1999) Neurons undergo apoptosis in animal and cell culture models of diabetes. Neurobiol Dis 6:347–363

    CAS  PubMed  Google Scholar 

  • Sabin TD, Geschwind N, Waxman SG (1978) Patterns of clinical deficits in peripheral nerve disease. In: Waxman SG (ed) Physiology and pathobiology of axons. Raven Press, New York, pp 431–438

    Google Scholar 

  • Sahenk Z, Mendell JR, Corui D et al (1978) Polyneuropathy from inhalation of nitrous oxide cartridges through a whipped cream dispenser. Neurology 28:485–487

    CAS  PubMed  Google Scholar 

  • Said G (1980) A clinicopathologic study of acrodystrophic neuropathies. Muscle Nerve 3:491–501

    CAS  PubMed  Google Scholar 

  • Said G, Landrieu P (1978) Etude quantitative des fibres nerveuses isolees dans les polynevrites alcooliques. J Neurol Sci 35:317–330

    CAS  PubMed  Google Scholar 

  • Said G, Boudier L, Zingraff J et al (1983a) Different patterns of uremic polyneuropathy: a clinicopathologic study. Neurology 33:567–574

    CAS  PubMed  Google Scholar 

  • Said G, Slama G, Selva J (1983b) Progressive centripetal degeneration of axons in small fibre type diabetic polyneuropathy. A clinical and pathological study. Brain 106:791–807

    PubMed  Google Scholar 

  • Said G, Goulon-Goeau C, Slama G, Tchobroutsky G (1992) Severe early-onset polyneuropathy in insulin-dependent diabetes mellitus. A clinical and pathological study. N Engl J Med 326:1257–1264

    CAS  PubMed  Google Scholar 

  • Said G, Goulon-Goeau C, Lacroix C et al (1994) Nerve biopsy findings in different patterns of proximal diabetic neuropathy. Ann Neurol 35:559–569

    CAS  PubMed  Google Scholar 

  • Said G, Lacroix C, Lozeron P et al (2003) Inflammatory vasculopathy in multifocal diabetic neuropathy. Brain 126(Part 2):376–385

    PubMed  Google Scholar 

  • Saunders DE, DiCerbo JA, Williams JR et al (1997) Alcohol reduces neurofilament protein levels in primary cultured hippocampal neurons. Alcohol 14:519–526

    CAS  PubMed  Google Scholar 

  • Schaumburg HH, Kaplan J, Windebank A et al (1983) Sensory neuropathy from pyridoxine abuse. N Engl J Med 309:445–448

    CAS  PubMed  Google Scholar 

  • Schmidt RE (1996) Synaptic dysplasia in sympathetic autonomic ganglia. J Neurocytol 25:777–791

    CAS  PubMed  Google Scholar 

  • Schmidt RE (2002) Neuropathology and pathogenesis of diabetic autonomic neuropathy. In: Tomlinson DR (ed) Neurobiology of diabetic neuropathy. Academic, Amsterdam, pp 267–292

    Google Scholar 

  • Schmidt RE, Plurad SB, Parvin CA, Roth KA (1993) The effect of diabetes and aging on human sympathetic autonomic ganglia. Am J Pathol 143:143–153

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schmidt RE, Dorsey D, Parvin CA et al (1997) Dystrophic axonal swellings develop as a function of age and diabetes in human dorsal root ganglia. J Neuropathol Exp Neurol 56:1028–1043

    CAS  PubMed  Google Scholar 

  • Schmidt RE, Bilbao JM (in press) Chapter 21. Diseases of peripheral nerve. In: Love S, Perry A, Ironside J, Budka H (eds) Greenfield’s neuropathology, 9 edn

    Google Scholar 

  • Schochet SS, Chesson AL Jr (1977) Giant axonal neuropathy: possibly secondary to Vitamin B12 malabsorption. Acta Neuropathol 40:79–83

    PubMed  Google Scholar 

  • Seneviratne KN, Peiris OA (1970) Peripheral nerve function in chronic liver disease. J Neurol Neurosurg Psychiatry 33:609–614

    CAS  PubMed Central  PubMed  Google Scholar 

  • Shirabe T, Tawara S, Terao A, Araki S (1975) Myxoedematous polyneuropathy: a light and electron microscopic study of the peripheral nerve and muscle. J Neurol Neurosurg Psychiatry 38:241–247

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sidenius P, Jakobsen J (1987) Axonal transport in human and experimental diabetes. In: Dyck P, Thomas PK, Asbury A et al (eds) Diabetic neuropathy. WB Saunders, Philadelphia, pp 260–265

    Google Scholar 

  • Sima AAF (1993) Diabetic neuropathy-the presence and future of a common but silent disorder. Mod Pathol 6:399–401

    CAS  PubMed  Google Scholar 

  • Sima AAF, Bril V, Nathaniel V et al (1988a) Regeneration and repair of myelinated fibers in sural nerve biopsies from patients with diabetic neuropathy treated with an aldose reductase inhibitor. N Engl J Med 319:548–555

    CAS  PubMed  Google Scholar 

  • Sima AAF, Nathaniel V, Bril V et al (1988b) Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin dependent diabetics and demonstration of axoglial dysjunction in human diabetic neuropathy. J Clin Invest 81:349–364

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sima AAF, Nathaniel V, Prashar A et al (1991) Endoneurial microvessels in human diabetic neuropathy. Endothelial cell dysjunction and lack of treatment effect by aldose reductase inhibitor. Diabetes 40:1090–1099

    CAS  PubMed  Google Scholar 

  • Sima AA, Zhang W, Xu G et al (2000) A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. Diabetologia 43:786–793

    CAS  PubMed  Google Scholar 

  • Sladky JT, Tschoepe RL, Greenberg JH, Brown MJ (1991) Peripheral neuropathy after chronic endoneurial ischemia. Ann Neurol 29:272–278

    CAS  PubMed  Google Scholar 

  • Smith AG, Ramachandran P, Tripp S, Singleton JR (2001) Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy. Neurology 57:1701–1704

    CAS  PubMed  Google Scholar 

  • Stein SA, Kirkpatrick LL, Shanklin DR et al (1991) Hypothyroidism selectively reduces the rate and amount of transport for specific SCb protein in the hyt/hyt mouse optic nerve. J Neurosci Res 30:28–41

    CAS  PubMed  Google Scholar 

  • Steiner I, Kidron D, Soffer D et al (1988) Sensory peripheral neuropathy of vitamin B12 deficiency: a primary demyelinating disease? J Neurol 235:163–164

    CAS  PubMed  Google Scholar 

  • Stewart BJ (1966) The hypertrophic neuropathy of acromegaly: a rare neuropathy associated with acromegaly. Arch Neurol 14:1–7

    Google Scholar 

  • Su CP (1976) Congenital folate deficiency. N Engl J Med 294:1128

    CAS  PubMed  Google Scholar 

  • Sugimura K, Dyck PJ (1981) Sural nerve myelin thickness and axis cylinder caliber in human diabetics. Neurology 31:1087–1091

    CAS  PubMed  Google Scholar 

  • Sugimura K, Dyck PJ (1982) Multifocal fiber loss in proximal sciatic nerve in symmetric diabetic neuropathy. J Neurol Sci 53:501–509

    CAS  PubMed  Google Scholar 

  • Szollar SM, Czyrny JJ, Heffner RR Jr (1988) Neurologic complications of thyrotoxicosis: case report. Arch Phys Med Rehabil 69:41–43

    CAS  PubMed  Google Scholar 

  • Tabaraud F, Vallat JM, Hugon J et al (1990) Acute or subacute alcoholic neuropathy mimicking Guillain Barre syndrome. J Neurol Sci 97:195–205

    CAS  PubMed  Google Scholar 

  • Takahashi K, Nakamura H (1976) Axonal degeneration in beriberi neuropathy. Arch Neurol 33:836–841

    CAS  PubMed  Google Scholar 

  • Takeuchi M, Saito T (2005) Cytotoxicity of acetaldehyde-derived advanced glycation end-products (AA-AGE) in alcoholic-induced neuronal degeneration. Alcohol Clin Exp Res 29(12 Suppl):220S–224S

    CAS  PubMed  Google Scholar 

  • Theriault M, Dort J, Sutherland G, Zochodne DW (1997) Local human sural nerve blood flow in diabetic and other polyneuropathies. Brain 120(Part 7):1131–1138

    PubMed  Google Scholar 

  • Thomas PK (1992) Diabetic neuropathy: models, mechanism, and mayhem. Can J Neurol Sci 19:1–7

    CAS  PubMed  Google Scholar 

  • Thomas PK, Lascelles RC (1966) The pathology of diabetic neuropathy. Q J Med 35:489–509

    Google Scholar 

  • Thomas PK, Tomlinson DR (1993) Diabetic and hypoglycemic neuropathy. In: Dyck PJ, Thomas PK et al (eds) Peripheral neuropathy, 3rd edn. WB Saunders, Philadelphia, pp 1219–1250

    Google Scholar 

  • Thomas PK, Walker JG (1965) Xanthomatous neuropathy in primary biliary cirrhosis. Brain 88:1079–1088

    CAS  PubMed  Google Scholar 

  • Thomas PK, Hollinrake K, Lascelles RG et al (1971) The polyneuropathy of chronic renal failure. Brain 94:761–780

    CAS  PubMed  Google Scholar 

  • Thornalley P (2002) Glycation in diabetic neuropathy: characteristics, consequences, causes and therapeutic options. In: Tomlinson DR (ed) Neurobiology of diabetic neuropathy. Academic, Amsterdam, pp 38–57

    Google Scholar 

  • Timiras PS, Nzekwe EU (1989) Thyroid hormones and nervous system development. Biol Neonate 55:376–385

    CAS  PubMed  Google Scholar 

  • Timperley WR, Boulton AJ, Davies-Jones GA et al (1985) Small vessel disease in progressive neuropathy associated with good metabolic control. J Clin Pathol 38:1030–1038

    CAS  PubMed Central  PubMed  Google Scholar 

  • Tredici G, Minazzi M (1975) Alcoholic neuropathy. An electron microscopic study. J Neurol Sci 25:333–346

    CAS  PubMed  Google Scholar 

  • Tsai SC, Burnakis TG (1993) Aldose reductase inhibitors: an update. Ann Pharmacother 27:751–754

    CAS  PubMed  Google Scholar 

  • Tsukada N, Koh CS, Inoue A, Yanagisawa N (1987) Demyelinating neuropathy associated with hepatitis B virus infection. Detection of immune complexes composed of hepatitis B virus surface antigen. J Neurol Sci 77:203–216

    CAS  PubMed  Google Scholar 

  • UK Prospective Diabetes Study Group (1998) Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type II diabetes. Lancet 352:837–853

    Google Scholar 

  • Vedder E (1938) The pathology of beriberi. J Am Med Assoc 110:893–896

    Google Scholar 

  • Victor M, Adams RD, Collin GH (1990) The Wernicke Korsakoff Syndrome and related neurologic disorders due to alcoholism and malnutrition, 2nd edn. FA Davis, Philadelphia

    Google Scholar 

  • Vincent AM, Hinder LM, Pop-Busui R et al (2009) Hyperlipidemia: a new therapeutic target for diabetic neuropathy. J Peripher Nerv Syst 14:257–267

    CAS  PubMed  Google Scholar 

  • Vincent AM, Callaghan BC, Smith AL, Feldman EL (2011) Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nat Rev Neurol 7:573–583

    CAS  PubMed  Google Scholar 

  • Vishnubhakat SM, Beresford HR (1991) Reversible myeloneuropathy of nitrous oxide abuse: serial electrophysiological studies. Muscle Nerve 14:22–26

    CAS  PubMed  Google Scholar 

  • Vital C, LeBlanc M, Vallat JM et al (1974) Etude ultrasturctuale du nerf peripherique chez 16 diabetiques sans neuropathie clinique: comparaisons avec 16 neuropathie diabetiques et 16 neuropathie non diabetiques. Acta Neuropathol 30:63–72

    CAS  PubMed  Google Scholar 

  • Walsh JC, McLeod JG (1970) Alcoholic neuropathy: an electrophysiological and histological study. J Neurol Sci 10:457–469

    CAS  PubMed  Google Scholar 

  • Watanabe S, Ohnishi A (1979) Subperineurial space of the sural nerve in various peripheral nerve diseases. Acta Neuropathol 46:227–230

    CAS  PubMed  Google Scholar 

  • Watanakunakorn C, Hodges RE, Evans TG (1965) Myxedema. A study of 400 cases. Arch Intern Med 116:183–190

    CAS  PubMed  Google Scholar 

  • Watkins PJ, Thomas PK (1998) Diabetes mellitus and the nervous system. J Neurol Neurosurg Psychiatry 65:620–632

    CAS  PubMed Central  PubMed  Google Scholar 

  • Waxman SG, Brill MH, Geschwind N et al (1976) Probability of conduction deficit as related to fiber length in random distribution models of peripheral neuropathies. J Neurol Sci 29:39–53

    CAS  PubMed  Google Scholar 

  • Way KJ, Katai N, King GL (2001) Protein kinase C and the development of diabetic vascular complications. Diabet Med 18:945–959

    CAS  PubMed  Google Scholar 

  • Whiting DR, Guariguata L, Weil C et al (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94:311–321

    PubMed  Google Scholar 

  • Windebank AJ (1993) Polyneuropathy due to nutritional deficiency and alcoholism. In: Dyck PJ, Thomas PK et al (eds) Peripheral neuropathy, 3rd edn. WB Saunders, Philadelphia, pp 1310–1321

    Google Scholar 

  • Yagihashi S, Matsunaga M (1979) Ultrastructural pathology of peripheral nerves in patients with diabetic neuropathy. Tohoku J Exp Med 129:357–366

    CAS  PubMed  Google Scholar 

  • Yasuda H, Dyck PJ (1987) Abnormalities of endoneurial microvessels and sural nerve pathology in diabetic neuropathy. Neurology 37:20–28

    CAS  PubMed  Google Scholar 

  • Younger DS (2011) Diabetic lumbosacral radiculoplexus neuropathy: a postmortem studied patients and review of the literature. J Neurol 258:1364–1367

    PubMed Central  PubMed  Google Scholar 

  • Younger DS, Rosoklija G, Hays AP et al (1996) Diabetic peripheral neuropathy: a clinicopathologic and immunohistochemical analysis of sural nerve biopsies. Muscle Nerve 19:722–727

    CAS  PubMed  Google Scholar 

  • Zenker J, Ziegler D, Chrast R (2013) Novel pathogenic pathways in diabetic neuropathy. Trends Neurosci 36:439–449

    CAS  PubMed  Google Scholar 

  • Zherebitskaya E, Akude E, Smith DR, Fernyhough P (2009) Development of selective axonopathy in adult sensory neurons isolated from diabetic rats role of glucose-induced oxidative stress. Diabetes 58:1356–1364

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zherebitskaya E, Schapansky J, Akude E et al (2011) Sensory neurons derived from diabetic rats have diminished internal Ca2+ stores linked to impaired re-uptake by the endoplasmic reticulum. ASN Neuro 1:art:e00072. doi:10.1042/AN20110038

  • Zochodne DW (2002) Nerve and ganglion blood flow in diabetes: an appraisal. Int Rev Neurobiol 50:161–202

    PubMed  Google Scholar 

  • Zochodne DW, Ho LT (1992) Normal blood flow but lower oxygen tension in diabetes of young rats: microenvironment and the influence of sympathectomy. Can J Physiol Pharmacol 70:651–659

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Sunnybrook and St Michael’s Hospitals, University of Toronto, Toronto, ON, Canada

    Juan M. Bilbao MD, FRCP (C) (Professor Emeritus of Neuropathology)

  2. Division of Neuropathology Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA

    Robert E. Schmidt MD, PhD (Professor of Pathology and Immunology Director)

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Bilbao, J.M., Schmidt, R.E. (2015). Neuropathy Associated with Endocrine and Metabolic Disease. In: Biopsy Diagnosis of Peripheral Neuropathy. Springer, Cham. https://doi.org/10.1007/978-3-319-07311-8_17

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