Abstract
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system. This chronic illness affects mainly young people and can lead to significant disabilities. This chapter discusses MS incidence, prevalence, clinical pattern and other aspects of the disease in the Arab World. Although the prevalence of MS among Arabs ranges from low to high, recent studies indicate that Arab countries are in the higher MS frequency zone. There is evidence from Kuwait indicating that there is an increase in the incidence and prevalence of MS. The overall clinical pattern in Arab patients with MS is similar to “Western type” MS. There are indications that MS follows a more aggressive course in North Africans and in the Druze living in Israel. Several factors showed prognostic value in Arab MS patients, including the extent of recovery from the first episode, the number of relapses, older age at onset, pyramidal or sphincter involvement at the start of the disease, age of onset, MS type, duration of illness, and use of interferon. The overall frequency of oligoclonal bands detected in cerebrospinal fluid of Arab patients with MS is lower than observed in most Western studies. Data about factors affecting the quality of life of MS patients in the Arab countries are available only from Kuwait. They show that longer duration of illness and treatment, depression, more severe disability, and carer’s negative attitude to the illness have a negative effect on quality of life. Further epidemiological and clinical studies about MS in Arab World are warranted.
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References
Ascherio A, Mungrt K. Multiple sclerosis. In: Nelson LM, Tanner CM, Van Den Eeden SK, McGuire VM, editors. Neuroepidemiology: from principles to practice. New York: Oxford University Press; 2004. p. 188–222.
Koch-Henriksen N, Sørensen PS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol. 2010;9(5):520–32.
Simpson S, Blizzard L, Otahal P, Van der Mei I, Taylor B. Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011;82(10):1132–41.
McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50(1):121–7.
Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005;58(6):840–6.
Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292–302.
Shaby JA. Multiple sclerosis in Iraq. Wien Z Nervenheilkd. 1958;15:267–83.
Alshubaili AF, Alramzy K, Ayyad YM, Gerish Y. Epidemiology of multiple sclerosis in Kuwait: new trends in incidence and prevalence. Eur Neurol. 2005;53(3):125–31.
Alroughani R, Ahmed S, Behbahani R, Khan R, Thussu A, Alexander K, et al. Increasing prevalence and incidence rates of multiple sclerosis in Kuwait. Mult Scler. 2014;20(5):543–47.
Ammar N, Gouider-Khouja N, Hentati F. A comparative study of clinical and paramedical aspects of multiple sclerosis in Tunisia. Rev Neurol (Paris). 2006;162(6–7):729–33.
Inshasi J, Thakre M. Prevalence of multiple sclerosis in Dubai, United Arab Emirates. Int J Neurosci. 2011;121(7):393–8.
Karni A, Kahana E, Zilber N, Abramsky O, Alter M, Karussis D. The frequency of multiple sclerosis in Jewish and Arab populations in greater Jerusalem. Neuroepidemiology. 2003;22(1):82–6.
Sharafaddinzadeh N, Moghtaderi A, Majdinasab N, Dahmardeh M, Kashipazha D, Shalbafan B. The influence of ethnicity on the characteristics of multiple sclerosis: a local population study between Persians and Arabs. Clin Neurol Neurosurg. 2013;115(8):1271–5.
Al-Din AS. Multiple sclerosis in Kuwait: clinical and epidemiological study. J Neurol Neurosurg Psychiatry. 1986;49(8):928–31.
Al-Din AS, Khogali M, Poser CM, Al-Nassar KE, Shakir R, Hussain J, et al. Epidemiology of multiple sclerosis in Arabs in Kuwait: a comparative study between Kuwaitis and Palestinians. J Neurol Sci. 1990;100(1–2):137–41.
Al-Din AS, El-Khateeb M, Kurdi A, Mubaidin A, Wriekat A, al-Shehab A, et al. Multiple sclerosis in Arabs in Jordan. J Neurol Sci. 1995;131(2):144–9.
Alter M, Kahana E, Zilber N, Miller A. Multiple sclerosis frequency in Israel’s diverse populations. Neurology. 2006;66(7):1061–6.
El-Salem K, Al-Shimmery E, Horany K, Al-Refai A, Al-Hayk K, Khader Y. Multiple sclerosis in Jordan: a clinical and epidemiological study. J Neurol. 2006;253(9):1210–6.
Yaqub BA, Daif AK. Multiple sclerosis in Saudi Arabia. Neurology. 1988;38(4):621–3.
Radhakrishnan K, Ashok PP, Sridharan R, Mousa ME. Prevalence and pattern of multiple sclerosis in Benghazi, north-eastern Libya. J Neurol Sci. 1985;70(1):39–46.
Hamdi TI. Multiple sclerosis in Iraq: a clinical and geomedical survey. J Postgrad Med. 1975;21(1):1–9.
Tharakan JJ, Chand RP, Jacob PC. Multiple sclerosis in Oman. Neurosciences (Riyadh). 2005;10(3):223–5.
Ben Hamida M. Epidemiological study of multiple sclerosis in Tunisia. Afr J Neurol Sci. 1982;1:45–7.
Attia Romdhane N, Ben Hamida M, Mrabet A, Larnaout A, Samoud S, Ben Hamda A, et al. Prevalence study of neurologic disorders in Kelibia (Tunisia). Neuroepidemiology. 1993;12(5):285–99.
El-Tallawy HN, Farghaly WM, Rageh TA, Shehata GA, Badry R, Metwally NA, et al. Door-to-door survey of major neurological disorders (project) in Al Quseir City, Red Sea Governorate, Egypt. Neuropsychiatr Dis Treat. 2013;9:767–71.
Deleu D, Mir D, Al Tabouki A, Mesraoua R, Mesraoua B, Akhtar N, et al. Prevalence, demographics and clinical characteristics of multiple sclerosis in Qatar. Mult Scler. 2013;19(6):816–9.
Multiple Sclerosis International Federation. Atlas of MS 2013: mapping multiple sclerosis around the world. 2013. www.atlasofms.org. Accessed 12 Dec 2013.
Benamer HT, Ahmed ES, Al-Din AS, Grosset DG. Frequency and clinical patterns of multiple sclerosis in Arab countries: a systematic review. J Neurol Sci. 2009;278(1–2):1–4.
Siegel M, Paperna T, Lejbkowicz I, Petrou P, Shahien R, Karussis D, et al. Multiple sclerosis in diverse populations: characteristics in distinct Arab ethnicities in Israel. Mult Scler. 2012;18(12):1737–44.
Kurtzke JF. MS epidemiology world wide. One view of current status. Acta Neurol Scand. 1995;161(Suppl):23–33.
Bohlega S, Inshasi J, Al Tahan AR, Madani AB, Qahtani H, Rieckmann P. Multiple sclerosis in the Arabian Gulf countries: a consensus statement. J Neurol. 2013;260(12):2959–63.
Al-Hashel J, Besterman AD, Wolfson C. The prevalence of multiple sclerosis in the Middle East. Neuroepidemiology. 2008;31(2):129–37.
Al-Afasy HH, Al-Obaidan MA, Al-Ansari YA, Al-Yatama SA, Al-Rukaibi MS, Makki NI, et al. Risk factors for multiple sclerosis in Kuwait: a population-based case-control study. Neuroepidemiology. 2013;40(1):30–5.
Sellner J, Kraus J, Awad A, Milo R, Hemmer B, Stüve O. The increasing incidence and prevalence of female multiple sclerosis–a critical analysis of potential environmental factors. Autoimmun Rev. 2011;10(8):495–502.
Al-Shimmery EK, Bzaini AS. Multiple sclerosis in Jordan and Iraq. Clinical and social overview. Neurosciences (Riyadh). 2008;13(3):276–82.
Al-Araji A, Mohammed AI. Multiple sclerosis in Iraq: does it have the same features encountered in Western countries? J Neurol Sci. 2005;234(1–2):67–71.
Al-Kadhi HI, Najim RA, Al-Alawi MS, Mousa KI, Al-Jibouri LM. Clinical and radiological response and side effects of beta interferon in Iraq patients with relapsing and remitting multiple sclerosis. Neurosciences (Riyadh). 2006;11(3):162–6.
Hasan ZN. Disability and prognosis of relapsing remitting multiple sclerosis, is it different in Iraqi patients? Neurosciences (Riyadh). 2011;16(3):233–6.
El-Salem K, Khader Y. Comparison of the natural history and prognostic features of early onset and adult onset multiple sclerosis in Jordanian population. Clin Neurol Neurosurg. 2007;109(1):32–7.
Bahou YG. Multiple sclerosis at Jordan University Hospital. Neurosciences (Riyadh). 2002;7(2):105–8.
Al-Kurdi A, Dahdaleh MP. Multiple sclerosis in Jordan. Saudi Med J. 1996;17(1):62–5.
Alroughani R, Ashkanani A, Lamdhade S. Clinical characteristics of multiple sclerosis in Kuwait: data from the new MS registry of Amiri Hospital. Int J Neurosci. 2012;122(2):82–7.
Yamout B, Barada W, Tohme RA, Mehio-Sibai A, Khalifeh R, El-Hajj T. Clinical characteristics of multiple sclerosis in Lebanon. J Neurol Sci. 2008;270(1–2):88–93.
Sawaya RA, Kanso MI. Multiple sclerosis in Lebanon: a review of 45 cases. Mult Scler. 2009;15(2):279–80.
Yamout B, Itani S, Arabi A, Hamzeh D, Yaghi S. Prognostic factors of multiple sclerosis in Lebanon. Int J Neurosci. 2010;120(3):206–10.
Akhtar N, Elsetouhy A, Deleu D, Kamran S, Al Hail H, Elalamy O, et al. Newly diagnosed multiple sclerosis in state of Qatar. Clin Neurol Neurosurg. 2013;115(8):1333–7.
Daif AK, Al-Rajeh S, Awada A, Al Bunyan M, Ogunniyi A, AbdulJabar M, Al Tahan AR. Pattern of presentation of multiple sclerosis in Saudi Arabia: analysis based on clinical and paraclinical features. Eur Neurol. 1998;39(3):182–6.
Kargwell H, Yaqub BA, Al-Deeb SM. Response to beta interferon 1b among Saudi patients with multiple sclerosis. Saudi Med J. 2003;24(1):44–8.
Idris MN, Sokrab TE, Ibrahim EA, Ali HE, Elzibair MA, Abadalatif M, et al. Multiple sclerosis in Sudan: a prospective study of clinical presentation and outcome. Mult Scler. 2009;15(12):1537–8.
Debouverie M, Lebrun C, Jeannin S, Pittion-Vouyovitch S, Roederer T, Vespignani H. More severe disability of North Africans vs Europeans with multiple sclerosis in France. Neurology. 2007;68(1):29–32.
Al Jumah M, Kojan S, Al Khathaami A, Al Abdulkaream I, Al Blawi M, Jawhary A. Familial multiple sclerosis: does consanguinity have a role? Mult Scler. 2011;17(4):487–9.
Marrie RA, Cutter G, Tyry T, Vollmer T, Campagnolo D. Does multiple sclerosis-associated disability differ between races? Neurology. 2006;66(8):1235–40.
Yosef AR. Health beliefs, practice, and priorities for health care of Arab Muslims in the United States. J Transcult Nurs. 2008;19(3):284–91.
Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group. Neurology. 1993;43:655–61.
Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology. 1995;45(7):1277–85.
Alroughani R, Al Hashel J, Thussu A, Ahmed SF. Use of natalizumab in patients with active relapsing-remitting multiple sclerosis in Kuwait. Med Princ Pract. 2013;22(5):495–9.
Kremenchutzky M, Rice GP, Baskerville J, Wingerchuk DM, Ebers GC. The natural history of multiple sclerosis: a geographically based study 9: observations on the progressive phase of the disease. Brain. 2006;129(3):584–94.
Link H, Huang YM. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol. 2006;180(1–2):17–28.
Dobson R, Ramagopalan S, Davis A, Giovannoni G. Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude. J Neurol Neurosurg Psychiatry. 2013;84(8):909–14.
Andreadou E, Chatzipanagiotou S, Constantinides VC, Rombos A, Stamboulis E, Nicolaou C. Prevalence of cerebrospinal fluid oligoclonal IgG bands in Greek patients with clinically isolated syndrome and multiple sclerosis. Clin Neurol Neurosurg. 2013;115(10):2094–8.
Sá MJ, Sequeira L, Rio ME, Thompson EJ. Oligoclonal IgG bands in the cerebrospinal fluid of Portuguese patients with multiple sclerosis: negative results indicate benign disease. Arq Neuropsiquiatr. 2005;63(2B):375–9.
Chang KH, Lyu RK, Chen CM, Hsu WC, Wu YR, Chen ST, et al. Clinical characteristics of multiple sclerosis in Taiwan: a cross-sectional study. Mult Scler. 2006;12(4):501–6.
Li B, Dong H, Zhang J, Song X, Guo L. Cerebrospinal fluid IgG profiles and oligoclonal bands in Chinese patients with multiple sclerosis. Acta Neurol Scand. 2007;115(5):319–24.
Kikuchi S, Fukazawa T, Niino M, Yabe I, Miyagishi R, Hamada T, et al. HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigen. Neurology. 2003;60(4):647–51.
Alshubaili AF, Awadalla AW, Ohaeri JU, Mabrouk AA. Relationship of depression, disability, and family caregiver attitudes to the quality of life of Kuwaiti persons with multiple sclerosis: a controlled study. BMC Neurol. 2007;7:31.
Alshubaili AF, Ohaeri JU, Awadalla AW, Mabrouk AA. Family caregiver quality of life in multiple sclerosis among Kuwaitis: a controlled study. BMC Health Serv Res. 2008;8:206.
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Benamer, H.T.S. (2014). Multiple Sclerosis. In: Neurological Disorders in the Arab World. Springer, Cham. https://doi.org/10.1007/978-3-319-07257-9_7
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DOI: https://doi.org/10.1007/978-3-319-07257-9_7
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