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Neurophysiology of Migraine

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Vestibular Migraine and Related Syndromes

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Abstract

The neurophysiology of migraine covers different topics. Neurophysiological testing is usually not necessary to diagnose migraine but may be helpful in case of atypical aura symptoms or migraine presentation. The neurophysiological evaluation is able to detect some features of the migrainous brain (excitability, adaptation and sensitization) that may shed some light on migraine pathophysiology and, possibly, on drug treatment. Finally, the neurophysiological evaluation of the vestibular system is useful for the diagnosis of vestibular migraine.

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References

  1. Coppola G, Di Lorenzo C, Schoenen J, Pierelli F (2013) Habituation and sensitization in primary headaches. J Headache Pain 14:65

    PubMed Central  PubMed  Google Scholar 

  2. Sandrini G, Friberg L, Coppola G, Janig W, Jensen R et al (2011) Neurophysiological tests and neuroimaging procedures in non-acute headache (2nd edition). Eur J Neurol 18:373–381

    CAS  PubMed  Google Scholar 

  3. Ambrosini A, Magis D, Schoenen J (2010) Migraine – clinical neurophysiology. Handb Clin Neurol 97:275–293

    PubMed  Google Scholar 

  4. Brainin M, Barnes M, Baron JC, Gilhus NE, Hughes R et al (2004) Guidance for the preparation of neurological management guidelines by EFNS scientific task forces – revised recommendations 2004. Eur J Neurol 11:577–581

    CAS  PubMed  Google Scholar 

  5. Sand T (2003) Electroencephalography in migraine: a review with focus on quantitative electroencephalography and the migraine vs. epilepsy relationship. Cephalalgia 23(Suppl 1):5–11

    PubMed  Google Scholar 

  6. Sand T (1991) EEG in migraine: a review of the literature. Funct Neurol 6:7–22

    CAS  PubMed  Google Scholar 

  7. Lauritzen M, Trojaborg W, Olesen J (1981) EEG during attacks of common and classical migraine. Cephalalgia 1:63–66

    CAS  PubMed  Google Scholar 

  8. Schoenen J, Jamart B, Delwaide PJ (1987) Electroencephalographic mapping in migraine during the critical and intercritical periods. Rev Electroencephalogr Neurophysiol Clin 17:289–299

    CAS  PubMed  Google Scholar 

  9. Khalil NM, Legg NJ, Anderson DJ (2000) Long term decline of P100 amplitude in migraine with aura. J Neurol Neurosurg Psychiatry 69:507–511

    CAS  PubMed Central  PubMed  Google Scholar 

  10. Raudino F (1988) Visual evoked potential in patients with migraine. Headache 28:531–533

    CAS  PubMed  Google Scholar 

  11. Tagliati M, Sabbadini M, Bernardi G, Silvestrini M (1995) Multichannel visual evoked potentials in migraine. Electroencephalogr Clin Neurophysiol 96:1–5

    CAS  PubMed  Google Scholar 

  12. Shibata K, Yamane K, Nishimura Y, Kondo H, Otuka K (2011) Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study. Doc Ophthalmol 123:65–73

    PubMed  Google Scholar 

  13. Shibata K, Yamane K, Iwata M, Ohkawa S (2005) Evaluating the effects of spatial frequency on migraines by using pattern-reversal visual evoked potentials. Clin Neurophysiol 116:2220–2227

    CAS  PubMed  Google Scholar 

  14. Sand T, Vingen JV (2000) Visual, long-latency auditory and brainstem auditory evoked potentials in migraine: relation to pattern size, stimulus intensity, sound and light discomfort thresholds and pre-attack state. Cephalalgia 20:804–820

    CAS  PubMed  Google Scholar 

  15. Dash AK, Panda N, Khandelwal G, Lal V, Mann SS (2008) Migraine and audiovestibular dysfunction: is there a correlation? Am J Otolaryngol 29:295–299

    PubMed  Google Scholar 

  16. Chayasirisobhon S (1995) Somatosensory evoked potentials in acute migraine with sensory aura. Clin Electroencephalogr 26:65–69

    CAS  PubMed  Google Scholar 

  17. de Tommaso M (2008) Laser-evoked potentials in primary headaches and cranial neuralgias. Expert Rev Neurother 8:1339–1345

    PubMed  Google Scholar 

  18. de Tommaso M, Federici A, Franco G, Ricci K, Lorenzo M et al (2012) Suggestion and pain in migraine: a study by laser evoked potentials. CNS Neurol Disord Drug Targets 11:110–126

    PubMed  Google Scholar 

  19. de Tommaso M, Libro G, Guido M, Difruscolo O, Losito L et al (2004) Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. Neurosci Lett 363:272–275

    PubMed  Google Scholar 

  20. de Tommaso M, Losito L, Libro G, Guido M, Di Fruscolo O et al (2005) Effects of symptomatic treatments on cutaneous hyperalgesia and laser evoked potentials during migraine attack. Cephalalgia 25:359–368

    PubMed  Google Scholar 

  21. Mesulam MM (1990) Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol 28:597–613

    CAS  PubMed  Google Scholar 

  22. Akben SB, Subasi A, Tuncel D (2011) Analysis of EEG signals under flash stimulation for migraine and epileptic patients. J Med Syst 35:437–443

    PubMed  Google Scholar 

  23. Anagnostou E, Spengos K, Naoumis D, Paraskevas GP, Vassilopoulou S et al (2009) Lack of visual evoked potential habituation in the syndrome of HaNDL. J Neurol 256:1374–1376

    CAS  PubMed  Google Scholar 

  24. Chen WT, Wang SJ, Fuh JL, Ko YC, Lee YC et al (2012) Visual cortex excitability and plasticity associated with remission from chronic to episodic migraine. Cephalalgia 32:537–543

    PubMed  Google Scholar 

  25. Coppola G, Curra A, Sava SL, Alibardi A, Parisi V et al (2010) Changes in visual-evoked potential habituation induced by hyperventilation in migraine. J Headache Pain 11:497–503

    PubMed Central  PubMed  Google Scholar 

  26. de Tommaso M, Stramaglia S, Marinazzo D, Guido M, Lamberti P et al (2004) Visually evoked phase synchronisation changes of alpha rhythm in migraine. Correlations with clinical features. Neurol Sci 25(Suppl 3):S283–S284

    PubMed  Google Scholar 

  27. Judit A, Sandor PS, Schoenen J (2000) Habituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack. Cephalalgia 20:714–719

    CAS  PubMed  Google Scholar 

  28. Sand T, Zhitniy N, White LR, Stovner LJ (2008) Visual evoked potential latency, amplitude and habituation in migraine: a longitudinal study. Clin Neurophysiol 119:1020–1027

    PubMed  Google Scholar 

  29. Shibata K, Yamane K, Iwata M (2006) Change of excitability in brainstem and cortical visual processing in migraine exhibiting allodynia. Headache 46:1535–1544

    PubMed  Google Scholar 

  30. de Tommaso M, Guido M, Libro G, Losito L, Difruscolo O et al (2004) Interictal lack of habituation of mismatch negativity in migraine. Cephalalgia 24:663–668

    PubMed  Google Scholar 

  31. Sand T, Zhitniy N, White LR, Stovner LJ (2008) Brainstem auditory-evoked potential habituation and intensity-dependence related to serotonin metabolism in migraine: a longitudinal study. Clin Neurophysiol 119:1190–1200

    PubMed  Google Scholar 

  32. Lang E, Kaltenhauser M, Neundorfer B, Seidler S (2004) Hyperexcitability of the primary somatosensory cortex in migraine – a magnetoencephalographic study. Brain 127:2459–2469

    PubMed  Google Scholar 

  33. Ozkul Y, Uckardes A (2002) Median nerve somatosensory evoked potentials in migraine. Eur J Neurol 9:227–232

    CAS  PubMed  Google Scholar 

  34. Bohotin V, Fumal A, Vandenheede M, Gerard P, Bohotin C et al (2002) Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine. Brain 125:912–922

    CAS  PubMed  Google Scholar 

  35. Pierelli F, Iacovelli E, Bracaglia M, Serrao M, Coppola G (2013) Abnormal sensorimotor plasticity in migraine without aura patients. Pain 154:1738–1742

    PubMed  Google Scholar 

  36. Coppola G, Vandenheede M, Di Clemente L, Ambrosini A, Fumal A et al (2005) Somatosensory evoked high-frequency oscillations reflecting thalamo-cortical activity are decreased in migraine patients between attacks. Brain 128:98–103

    PubMed  Google Scholar 

  37. Di Clemente L, Coppola G, Magis D, Fumal A, De Pasqua V et al (2005) Nociceptive blink reflex and visual evoked potential habituations are correlated in migraine. Headache 45:1388–1393

    PubMed  Google Scholar 

  38. Di Clemente L, Coppola G, Magis D, Gerardy PY, Fumal A et al (2009) Nitroglycerin sensitises in healthy subjects CNS structures involved in migraine pathophysiology: evidence from a study of nociceptive blink reflexes and visual evoked potentials. Pain 144:156–161

    PubMed  Google Scholar 

  39. Kroner-Herwig B, Ruhmland M, Zintel W, Siniatchkin M (2005) Are migraineurs hypersensitive? A test of the stimulus processing disorder hypothesis. Eur J Pain 9:661–671

    PubMed  Google Scholar 

  40. Magis D, Vigano A, Sava S, D’Elia TS, Schoenen J et al (2013) Pearls and pitfalls: electrophysiology for primary headaches. Cephalalgia 33:526–539

    PubMed  Google Scholar 

  41. de Tommaso M, Libro G, Guido M, Losito L, Lamberti P et al (2005) Habituation of single CO2 laser-evoked responses during interictal phase of migraine. J Headache Pain 6:195–198

    PubMed Central  PubMed  Google Scholar 

  42. de Tommaso M, Lo Sito L, Di Fruscolo O, Sardaro M, Pia Prudenzano M et al (2005) Lack of habituation of nociceptive evoked responses and pain sensitivity during migraine attack. Clin Neurophysiol 116:1254–1264

    PubMed  Google Scholar 

  43. de Tommaso M, Valeriani M, Sardaro M, Serpino C, Fruscolo OD et al (2009) Pain perception and laser evoked potentials during menstrual cycle in migraine. J Headache Pain 10:423–429

    PubMed Central  PubMed  Google Scholar 

  44. Ferraro D, Vollono C, Miliucci R, Virdis D, De Armas L et al (2012) Habituation to pain in “medication overuse headache”: a CO2 laser-evoked potential study. Headache 52:792–807

    PubMed  Google Scholar 

  45. Chen WT, Wang SJ, Fuh JL, Lin CP, Ko YC et al (2009) Peri-ictal normalization of visual cortex excitability in migraine: an MEG study. Cephalalgia 29:1202–1211

    PubMed  Google Scholar 

  46. Coppola G, Parisi V, Di Lorenzo C, Serrao M, Magis D et al (2013) Lateral inhibition in visual cortex of migraine patients between attacks. J Headache Pain 14:20

    PubMed Central  PubMed  Google Scholar 

  47. Coppola G, Curra A, Di Lorenzo C, Parisi V, Gorini M et al (2010) Abnormal cortical responses to somatosensory stimulation in medication-overuse headache. BMC Neurol 10:126

    PubMed Central  PubMed  Google Scholar 

  48. de Tommaso M, Guido M, Libro G, Losito L, Sciruicchio V et al (2002) Abnormal brain processing of cutaneous pain in migraine patients during the attack. Neurosci Lett 333:29–32

    PubMed  Google Scholar 

  49. Burstein R, Cutrer MF, Yarnitsky D (2000) The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain 123(Pt 8):1703–1709

    PubMed  Google Scholar 

  50. de Tommaso M, Valeriani M, Guido M, Libro G, Specchio LM et al (2003) Abnormal brain processing of cutaneous pain in patients with chronic migraine. Pain 101:25–32

    PubMed  Google Scholar 

  51. Kaube H, Katsarava Z, Przywara S, Drepper J, Ellrich J et al (2002) Acute migraine headache: possible sensitization of neurons in the spinal trigeminal nucleus? Neurology 58:1234–1238

    CAS  PubMed  Google Scholar 

  52. Ayzenberg I, Obermann M, Nyhuis P, Gastpar M, Limmroth V et al (2006) Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures. Cephalalgia 26:1106–1114

    CAS  PubMed  Google Scholar 

  53. Afra J, Mascia A, Gerard P, Maertens de Noordhout A, Schoenen J (1998) Interictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices. Ann Neurol 44:209–215

    CAS  PubMed  Google Scholar 

  54. Antal A, Arlt S, Nitsche MA, Chadaide Z, Paulus W (2006) Higher variability of phosphene thresholds in migraineurs than in controls: a consecutive transcranial magnetic stimulation study. Cephalalgia 26:865–870

    CAS  PubMed  Google Scholar 

  55. Aurora SK, Ahmad BK, Welch KM, Bhardhwaj P, Ramadan NM (1998) Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology 50:1111–1114

    CAS  PubMed  Google Scholar 

  56. Aurora SK, Barrodale P, Chronicle EP, Mulleners WM (2005) Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness. Headache 45:546–552

    PubMed  Google Scholar 

  57. Aurora SK, Welch KM, Al-Sayed F (2003) The threshold for phosphenes is lower in migraine. Cephalalgia 23:258–263

    CAS  PubMed  Google Scholar 

  58. Brighina F, Piazza A, Daniele O, Fierro B (2002) Modulation of visual cortical excitability in migraine with aura: effects of 1 Hz repetitive transcranial magnetic stimulation. Exp Brain Res 145:177–181

    PubMed  Google Scholar 

  59. Brigo F, Storti M, Nardone R, Fiaschi A, Bongiovanni LG et al (2012) Transcranial magnetic stimulation of visual cortex in migraine patients: a systematic review with meta-analysis. J Headache Pain 13:339–349

    PubMed Central  PubMed  Google Scholar 

  60. Gunaydin S, Soysal A, Atay T, Arpaci B (2006) Motor and occipital cortex excitability in migraine patients. Can J Neurol Sci 33:63–67

    PubMed  Google Scholar 

  61. Khedr EM, Ahmed MA, Mohamed KA (2006) Motor and visual cortical excitability in migraineurs patients with or without aura: transcranial magnetic stimulation. Neurophysiol Clin 36:13–18

    PubMed  Google Scholar 

  62. Lo YL, Lum SY, Fook-Chong S, Cui SL, Siow HC (2008) Clinical correlates of phosphene perception in migraine without aura: an Asian study. J Neurol Sci 264:93–96

    CAS  PubMed  Google Scholar 

  63. Mulleners WM, Chronicle EP, Palmer JE, Koehler PJ, Vredeveld JW (2001) Visual cortex excitability in migraine with and without aura. Headache 41:565–572

    CAS  PubMed  Google Scholar 

  64. Mulleners WM, Chronicle EP, Palmer JE, Koehler PJ, Vredeveld JW (2001) Suppression of perception in migraine: evidence for reduced inhibition in the visual cortex. Neurology 56:178–183

    CAS  PubMed  Google Scholar 

  65. Palermo A, Fierro B, Giglia G, Cosentino G, Puma AR et al (2009) Modulation of visual cortex excitability in migraine with aura: effects of valproate therapy. Neurosci Lett 467:26–29

    CAS  PubMed  Google Scholar 

  66. Siniatchkin M, Reich AL, Shepherd AJ, van Baalen A, Siebner HR et al (2009) Peri-ictal changes of cortical excitability in children suffering from migraine without aura. Pain 147:132–140

    PubMed  Google Scholar 

  67. Young W, Shaw J, Bloom M, Gebeline-Myers C (2008) Correlation of increase in phosphene threshold with reduction of migraine frequency: observation of levetiracetam-treated subjects. Headache 48:1490–1498

    PubMed  Google Scholar 

  68. Bohotin V, Fumal A, Vandenheede M, Bohotin C, Schoenen J (2003) Excitability of visual V1-V2 and motor cortices to single transcranial magnetic stimuli in migraine: a reappraisal using a figure-of-eight coil. Cephalalgia 23:264–270

    CAS  PubMed  Google Scholar 

  69. Clarke BM, Upton AR, Kamath MV, Al-Harbi T, Castellanos CM (2006) Transcranial magnetic stimulation for migraine: clinical effects. J Headache Pain 7:341–346

    PubMed Central  PubMed  Google Scholar 

  70. Diener HC (2010) Single-pulse transcranial magnetic stimulation: a new way to treat migraine attacks with aura. Lancet Neurol 9:335–337

    PubMed  Google Scholar 

  71. Lipton RB, Dodick DW, Silberstein SD, Saper JR, Aurora SK et al (2010) Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurol 9:373–380

    PubMed  Google Scholar 

  72. Magis D, Schoenen J (2012) Advances and challenges in neurostimulation for headaches. Lancet Neurol 11:708–719

    PubMed  Google Scholar 

  73. Martelletti P, Jensen RH, Antal A, Arcioni R, Brighina F et al (2013) Neuromodulation of chronic headaches: position statement from the European Headache Federation. J Headache Pain 14:86

    PubMed  Google Scholar 

  74. McComas A, Upton A (2009) Therapeutic transcranial magnetic stimulation in migraine and its implications for a neuroinflammatory hypothesis. Inflammopharmacology 17:68–75

    CAS  PubMed  Google Scholar 

  75. Misra UK, Kalita J, Bhoi SK (2012) High frequency repetitive transcranial magnetic stimulation (rTMS) is effective in migraine prophylaxis: an open labeled study. Neurol Res 34:547–551

    PubMed  Google Scholar 

  76. Misra UK, Kalita J, Bhoi SK (2013) High-rate repetitive transcranial magnetic stimulation in migraine prophylaxis: a randomized, placebo-controlled study. J Neurol 260:2793–2801

    PubMed  Google Scholar 

  77. Artemenko AR, Kurenkov AL, Filatova EG, Nikitin SS, Kaube H et al (2008) Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine. Cephalalgia 28:203–208

    CAS  PubMed  Google Scholar 

  78. Aurora SK, Barrodale PM, Vermaas AR, Rudra CB (2010) Topiramate modulates excitability of the occipital cortex when measured by transcranial magnetic stimulation. Cephalalgia 30:648–654

    CAS  PubMed  Google Scholar 

  79. Gerwig M, Niehaus L, Stude P, Katsarava Z, Diener HC (2012) Beta-blocker migraine prophylaxis affects the excitability of the visual cortex as revealed by transcranial magnetic stimulation. J Headache Pain 13:83–89

    CAS  PubMed Central  PubMed  Google Scholar 

  80. Strupp M, Versino M, Brandt T (2010) Vestibular migraine. Handb Clin Neurol 97:755–771

    PubMed  Google Scholar 

  81. Neuhauser HK, Radtke A, von Brevern M, Feldmann M, Lezius F et al (2006) Migrainous vertigo: prevalence and impact on quality of life. Neurology 67:1028–1033

    CAS  PubMed  Google Scholar 

  82. Dieterich M, Brandt T (1999) Episodic vertigo related to migraine (90 cases): vestibular migraine? J Neurol 246:883–892

    CAS  PubMed  Google Scholar 

  83. Lempert T, Olesen J, Furman J, Waterston J, Seemungal B et al (2012) Vestibular migraine: diagnostic criteria. J Vestib Res 22:167–172

    PubMed  Google Scholar 

  84. Headache Classification Committee of the International Headache S (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808

    Google Scholar 

  85. Marcus DA, Furman JM (2006) Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study. Med Sci Monit 12:I1–I7

    Google Scholar 

  86. Lewis RF, Priesol AJ, Nicoucar K, Lim K, Merfeld DM (2011) Dynamic tilt thresholds are reduced in vestibular migraine. J Vestib Res 21:323–330

    PubMed Central  PubMed  Google Scholar 

  87. Harno H, Hirvonen T, Kaunisto MA, Aalto H, Levo H et al (2003) Subclinical vestibulocerebellar dysfunction in migraine with and without aura. Neurology 61:1748–1752

    CAS  PubMed  Google Scholar 

  88. Bir LS, Ardic FN, Kara CO, Akalin O, Pinar HS et al (2003) Migraine patients with or without vertigo: comparison of clinical and electronystagmographic findings. J Otolaryngol 32:234–238

    PubMed  Google Scholar 

  89. Versino M, Sances G, Anghileri E, Colnaghi S, Albizzati C et al (2003) Dizziness and migraine: a causal relationship? Funct Neurol 18:97–101

    PubMed  Google Scholar 

  90. Celebisoy N, Gokcay F, Sirin H, Bicak N (2008) Migrainous vertigo: clinical, oculographic and posturographic findings. Cephalalgia 28:72–77

    CAS  PubMed  Google Scholar 

  91. Cass SP, Furman JM, Ankerstjerne K, Balaban C, Yetiser S et al (1997) Migraine-related vestibulopathy. Ann Otol Rhinol Laryngol 106:182–189

    CAS  PubMed  Google Scholar 

  92. Rzeski M, Stepien A, Kaczorowski Z (2008) Evaluation of the function of the vestibular system in patients with migraine. Neurol Neurochir Pol 42:518–524

    PubMed  Google Scholar 

  93. Teggi R, Colombo B, Bernasconi L, Bellini C, Comi G et al (2009) Migrainous vertigo: results of caloric testing and stabilometric findings. Headache 49:435–444

    PubMed  Google Scholar 

  94. Baier B, Stieber N, Dieterich M (2009) Vestibular-evoked myogenic potentials in vestibular migraine. J Neurol 256:1447–1454

    PubMed  Google Scholar 

  95. Hong SM, Kim SK, Park CH, Lee JH (2011) Vestibular-evoked myogenic potentials in migrainous vertigo. Otolaryngol Head Neck Surg 144:284–287

    PubMed  Google Scholar 

  96. Crevits L, Vanacker L, Verraes A (2012) Patients with migraine correctly estimate the visual verticality. Clin Neurol Neurosurg 114:313–315

    PubMed  Google Scholar 

  97. Asai M, Aoki M, Hayashi H, Yamada N, Mizuta K et al (2009) Subclinical deviation of the subjective visual vertical in patients affected by a primary headache. Acta Otolaryngol 129:30–35

    PubMed  Google Scholar 

  98. Liao LJ, Young YH (2004) Vestibular evoked myogenic potentials in basilar artery migraine. Laryngoscope 114:1305–1309

    PubMed  Google Scholar 

  99. Taylor RL, Zagami AS, Gibson WP, Black DA, Watson SR et al (2012) Vestibular evoked myogenic potentials to sound and vibration: characteristics in vestibular migraine that enable separation from Meniere’s disease. Cephalalgia 32:213–225

    PubMed  Google Scholar 

  100. Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T (2012) Vestibular migraine: long-term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology 79:1607–1614

    PubMed  Google Scholar 

  101. Neugebauer H, Adrion C, Glaser M, Strupp M (2013) Long-term changes of central ocular motor signs in patients with vestibular migraine. Eur Neurol 69:102–107

    PubMed  Google Scholar 

  102. Polensek SH, Tusa RJ (2010) Nystagmus during attacks of vestibular migraine: an aid in diagnosis. Audiol Neurootol 15:241–246

    PubMed  Google Scholar 

  103. von Brevern M, Zeise D, Neuhauser H, Clarke AH, Lempert T (2005) Acute migrainous vertigo: clinical and oculographic findings. Brain 128:365–374

    Google Scholar 

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Authors and Affiliations

  1. Department of Brain and Behavioural Sciences, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy

    Maurizio Versino MD

  2. Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

    Simone Sacco MD

  3. Department of Public Health, Experimental and Forensic Medicine, CSAM, Fondazione S. Maugeri IRCCS, University of Pavia, Pavia, Italy

    Silvia Colnaghi MD, PhD

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  1. Maurizio Versino MD
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  2. Simone Sacco MD
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  3. Silvia Colnaghi MD, PhD
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Correspondence to Maurizio Versino MD .

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Editors and Affiliations

  1. Dept of Neurology, San Raffaele Scientific Institute, Milano, Italy

    Bruno Colombo

  2. Dept of ENT, San Raffaele Scientific Institute, Milano, Italy

    Roberto Teggi

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Versino, M., Sacco, S., Colnaghi, S. (2014). Neurophysiology of Migraine. In: Colombo, B., Teggi, R. (eds) Vestibular Migraine and Related Syndromes. Springer, Cham. https://doi.org/10.1007/978-3-319-07022-3_2

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  • DOI: https://doi.org/10.1007/978-3-319-07022-3_2

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