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Pelvic Floor Neuromodulation in Neurologic Patients

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Electrical Stimulation for Pelvic Floor Disorders

Abstract

Patients with lesions above the pons usually continue to have reflex contractions of the detrusor, but the cerebral regulation of voiding and defecation is often lost. This is the case in lesions as from stroke, head injury, etc., which mostly continue to have a normal coordinated sphincteric function. However these patients may purposely increase sphincter activity during an overactive detrusor contraction to prevent urinary incontinence which would otherwise occur. This has been termed “pseudo-dyssynergia” because it is indistinguishable from true dyssynergia on a urodynamic record. Urinary incontinence in suprapontine lesions, such as stroke, Parkinson’s disease, and multiple sclerosis, is due to bladder overactivity.

Most frequent suprasacral lesions are spinal cord injury and multiple sclerosis. A spinal cord injury (SCI) is damage or trauma to the spinal cord that results in a loss or impaired function causing reduced mobility or feeling. Common causes of damage are trauma (car accident, gunshot, falls, sports injuries, etc.) or disease (transverse myelitis, poliomyelitis, spina bifida, Friedreich’s ataxia, etc.). In SCI, bowel and bladder dysfunctions have significant lifelong consequences, and neurogenic voiding dysfunction is a major contributor to the morbidity and mortality.

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References

  1. Norton C, Chelvanayagam S (2010) Bowel problems and coping strategies in people with multiple sclerosis. Br J Nurs 19(220):221–226

    Google Scholar 

  2. Nakipoglu GF, Kaya AZ, Orhan G, Tezen O, Tunc H, Ozgirgin N, Ak F (2009) Urinary dysfunction in multiple sclerosis. J Clin Neurosci 16:1321–1324

    Article  PubMed  CAS  Google Scholar 

  3. Krogh K, Ostergaard K, Sabroe S, Laurberg S (2008) Clinical aspects of bowel symptoms in Parkinson’s disease. Acta Neurol Scand 117:60–64

    PubMed  CAS  Google Scholar 

  4. Winge K, Skau AM, Stimpel H, Nielsen KK, Werdelin L (2006) Prevalence of bladder dysfunction in Parkinsons disease. Neurourol Urodyn 25:116–122

    Article  PubMed  Google Scholar 

  5. Hackler RH (1977) A 25-year prospective mortality in the spinal cord injured patient: comparison with the long-term living paraplegic. J Urol 117:486–492

    PubMed  CAS  Google Scholar 

  6. Soden RJ, Walsh J, Middleton JW, Craven ML, Rutkowski SB, Yeo JD (2000) Causes of death after spinal cord injury. Spinal Cord 38:604–610

    Article  PubMed  CAS  Google Scholar 

  7. Kessler TM, La Framboise D, Trelle S, Fowler CJ, Kiss G, Pannek J, Schurch B, Sievert KD, Engeler DS (2010) Sacral neuromodulation for neurogenic lower urinary tract dysfunction: systematic review and meta-analysis. Eur Urol 58:865–874

    Article  PubMed  Google Scholar 

  8. Worsøe J, Rasmussen M, Christensen P, Krogh K (2013) Neurostimulation for neurogenic bowel dysfunction. Gastroenterol Res Pract 2013:563294

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lombardi G, Nelli F, Mencarini M, Del Popolo G (2011) Clinical concomitant benefits on pelvic floor dysfunctions after sacral neuromodulation in patients with incomplete spinal cord injury. Spinal Cord 49:629–636

    Article  PubMed  CAS  Google Scholar 

  10. Lombardi G, Mondaini N, Macchiarella A, Cilotti A, Del Popolo G (2008) Clinical female sexual outcome after sacral neuromodulation implant for lower urinary tract symptom (LUTS). J Sex Med 5:1411–1417

    Article  PubMed  Google Scholar 

  11. Dorsher PT, McIntosh PM (2012) Neurogenic bladder. Adv Urol 2012:816274

    Article  PubMed  PubMed Central  Google Scholar 

  12. Weld KJ, Dmochowski RR (2000) Effect of bladder management on urological complications in spinal cord injured patients. J Urol 163:768–772

    Article  PubMed  CAS  Google Scholar 

  13. Linsenmeyer TA (2013) Use of botulinum toxin in individuals with neurogenic detrusor overactivity: state of the art review. J Spinal Cord Med 36:402–419

    Article  PubMed  PubMed Central  Google Scholar 

  14. Chartier-Kastler EJ, Ruud Bosch JL, Perrigot M, Chancellor MB, Richard F, Denys P (2000) Long-term results of sacral nerve stimulation (S3) for the treatment of neurogenic refractory urge incontinence related to detrusor hyperreflexia. J Urol 164:1476–1480

    Article  PubMed  CAS  Google Scholar 

  15. Wallace PA, Lane FL, Noblett KL (2007) Sacral nerve neuromodulation in patients with underlying neurologic disease. Am J Obstet Gynecol 197:96e1–96e5

    Google Scholar 

  16. Lombardi G, Del Popolo G (2009) Clinical outcome of sacral neuromodulation in incomplete spinal cord injured patients suffering from neurogenic lower urinary tract symptoms. Spinal Cord 47:486–491

    Article  PubMed  CAS  Google Scholar 

  17. Hohenfellner M, Humke J, Hampel C, Dahms S, Matzel K, Roth S, Thüroff JW, Schultz-Lampel D (2001) Chronic sacral neuromodulation for treatment of neurogenic bladder dysfunction: long-term results with unilateral implants. Urology 58:887–892

    Article  PubMed  CAS  Google Scholar 

  18. Chaabane W, Guillotreau J, Castel-Lacanal E, Abu-Anz S, De Boissezon X, Malavaud B, Marque P, Sarramon JP, Rischmann P, Game X (2011) Sacral neuromodulation for treating neurogenic bladder dysfunction: clinical and urodynamic study. Neurourol Urodyn 30:547–550

    Article  PubMed  Google Scholar 

  19. Lombardi G, Musco S, Celso M, Del Corso F, Del Popolo G (2014) Sacral neuromodulation for neurogenic non-obstructive urinary retention in incomplete spinal cord patients: a ten-year follow-up single-centre experience. Spinal Cord. doi:10.1038/sc.2013.155

    PubMed  Google Scholar 

  20. Sievert KD, Amend B, Gakis G, Toomey P, Badke A, Kaps HP, Stenzl A (2010) Early sacral neuromodulation prevents urinary incontinence after complete spinal cord injury. Ann Neurol 67:74–84

    Article  PubMed  Google Scholar 

  21. Schurch B, Reilly I, Reitz A, Curt A (2003) Electrophysiological recordings during the peripheral nerve evaluation (PNE) test in complete spinal cord injury patients. World J Urol 20:319–322

    PubMed  CAS  Google Scholar 

  22. Opisso E, Borau A, Rijkhoff NJ (2011) Urethral sphincter EMG-controlled dorsal penile/clitoral nerve stimulation to treat neurogenic detrusor overactivity. J Neural Eng 8:036001

    Article  PubMed  CAS  Google Scholar 

  23. Dalmose AL, Rijkhoff NJ, Kirkeby HJ, Nohr M, Sinkjaer T, Djurhuus JC (2003) Conditional stimulation of the dorsal penile/clitoral nerve may increase cystometric capacity in patients with spinal cord injury. Neurourol Urodyn 22:130–137

    Article  PubMed  CAS  Google Scholar 

  24. Opisso E, Borau A, Rodríguez A, Hansen J, Rijkhoff NJ (2008) Patient controller versus automatic stimulation of pudendal nerve afferents to treat neurogenic detrusor overactivity. J Urol 180:1403–1408

    Article  PubMed  CAS  Google Scholar 

  25. Spinelli M, Malaguti S, Giardiello G, Lazzeri M, Tarantola J, Van Den Hombergh U (2005) A new minimally invasive procedure for pudendal nerve stimulation to treat neurogenic bladder: description of the method and preliminary data. Neurourol Urodyn 24:305–309

    Article  PubMed  Google Scholar 

  26. Gaziev G, Topazio L, Iacovelli V, Asimakopoulos A, Di Santo A, De Nunzio C, Finazzi-Agrò E (2013) Percutaneous Tibial Nerve Stimulation (PTNS) efficacy in the treatment of lower urinary tract dysfunctions: a systematic review. BMC Urol 13:61

    Article  PubMed  Google Scholar 

  27. Burton C, Sajja A, Latthe PM (2012) Effectiveness of percutaneous posterior tibial nerve stimulation for overactive bladder: a systematic review and meta-analysis. Neurourol Urodyn 31:1206–1216

    Article  PubMed  CAS  Google Scholar 

  28. Amarenco G, Ismael SS, Even-Schneider A, Raibaut P, Demaille-Wlodyka S, Parratte B, Kerdraon J (2003) Urodynamic effect of acute transcutaneous posterior tibial nerve stimulation in overactive bladder. J Urol 169:2210–2215

    Article  PubMed  CAS  Google Scholar 

  29. de Sèze M, Raibaut P, Gallien P, Even-Schneider A, Denys P, Bonniaud V, Gamé X, Amarenco G (2011) Transcutaneous posterior tibial nerve stimulation for treatment of the overactive bladder syndrome in multiple sclerosis: results of a multicenter prospective study. Neurourol Urodyn 30:306–311

    Article  PubMed  Google Scholar 

  30. Kabay SC, Yucel M, Kabay S (2008) Acute effect of posterior tibial nerve stimulation on neurogenic detrusor overactivity in patients with multiple sclerosis: urodynamic study. Urology 71:641–645

    Article  PubMed  Google Scholar 

  31. Kabay S, Kabay SC, Yucel M, Ozden H, Yilmaz Z, Aras O, Aras B (2009) The clinical and urodynamic results of a 3-month percutaneous posterior tibial nerve stimulation treatment in patients with multiple sclerosis-related neurogenic bladder dysfunction. Neurourol Urodyn 28:964–968

    Article  PubMed  Google Scholar 

  32. Gobbi C, Digesu GA, Khullar V, El Neil S, Caccia G, Zecca C (2011) Percutaneous posterior tibial nerve stimulation as an effective treatment of refractory lower urinary tract symptoms in patients with multiple sclerosis: preliminary data from a multicentre, prospective, open label trial. Mult Scler 17:1514–1519

    Article  PubMed  CAS  Google Scholar 

  33. Fjorback MV, van Rey FS, van der Pal F, Rijkhoff NJ, Petersen T, Heesakkers JP (2007) Acute urodynamic effects of posterior tibial nerve stimulation on neurogenic detrusor overactivity in patients with MS. Eur Urol 51:464–470

    Article  PubMed  Google Scholar 

  34. Kabay SC, Kabay S, Yucel M, Ozden H (2009) Acute urodynamic effects of percutaneous posterior tibial nerve stimulation on neurogenic detrusor overactivity in patients with Parkinson’s disease. Neurourol Urodyn 28:62–67

    Article  PubMed  Google Scholar 

  35. Egon G, Barat M, Colombel P, Visentin C, Isambert JL, Guerin J (1998) Implantation of anterior sacral root stimulators combined with posterior sacral rhizotomy in spinal injury patients. World J Urol 16:342–349

    Article  PubMed  CAS  Google Scholar 

  36. Vignes JR, Bauchet L, Ohanna F (2007) Dorsal rhizotomy combined with anterior sacral root stimulation for neurogenic bladder. Acta Neurochir Suppl 97(Pt 1):323–331

    PubMed  CAS  Google Scholar 

  37. Brindley GS (1994) The first 500 patients with sacral anterior root stimulator implants: general description. Paraplegia 32:795–805

    Article  PubMed  CAS  Google Scholar 

  38. Van Kerrebroeck EV, van der Aa HE, Bosch JL, Koldewijn EL, Vorsteveld JH, Debruyne FM (1997) Sacral rhizotomies and electrical bladder stimulation in spinal cord injury. Part I: clinical and urodynamic analysis. Dutch Study Group on Sacral Anterior Root Stimulation. Eur Urol 31:263–271

    PubMed  Google Scholar 

  39. Katona F (1975) Stages of vegetative afferentation in reorganization of bladder control during intravesical electrotherapy. Urol Int 30:192–203

    Article  PubMed  CAS  Google Scholar 

  40. Katona F, Berényi M (1975) Intravesical transurethral electrotherapy in meningomyelocele patients. Acta Paediatr Acad Sci Hung 16:363–374

    PubMed  CAS  Google Scholar 

  41. Kaplan WE, Richards I (1986) Intravesical transurethral electrotherapy for the neurogenic bladder. J Urol 136:243–246

    PubMed  CAS  Google Scholar 

  42. Ebner A, Jiang C, Lindström S (1992) Intravesical electrical stimulation—an experimental analysis of the mechanism of action. J Urol 148:920–924

    PubMed  CAS  Google Scholar 

  43. Hong CH, Lee HY, Jin MH, Noh JY, Lee BH, Han SW (2009) The effect of intravesical electrical stimulation on bladder function and synaptic neurotransmission in the rat spinal cord after spinal cord injury. BJU Int 103:1136–1141

    Article  PubMed  Google Scholar 

  44. Lombardi G, Celso M, Mencarini M, Nelli F, Del Popolo G (2013) Clinical efficacy of intravesical electrostimulation on incomplete spinal cord patients suffering from chronic neurogenic non-obstructive retention: a 15-year single centre retrospective study. Spinal Cord 51:232–237

    Article  PubMed  CAS  Google Scholar 

  45. Lombardi G, Musco S, Celso M, Ierardi A, Nelli F, Del Corso F, Del Popolo G (2013) Intravesical electrostimulation versus sacral neuromodulation for incomplete spinal cord patients suffering from neurogenic non-obstructive urinary retention. Spinal Cord 51:571–578

    Article  PubMed  CAS  Google Scholar 

  46. Calabrò RS, Marullo M, Gervasi G, Marino S, Bramanti P (2011) Does intravesical electrostimulation improve neurogenic constipation? A case report. Eur J Gastroenterol Hepatol 23:614–616

    Article  PubMed  Google Scholar 

  47. Lebouvier T, Chaumette T, Paillusson S, Duyckaerts C, Bruley des Varannes S, Neunlist M, Derkinderen P (2009) The second brain and Parkinson’s disease. Eur J Neurosci 30:735–741

    Article  PubMed  Google Scholar 

  48. Preziosi G, Emmanuel A (2009) Neurogenic bowel dysfunction: pathophysiology, clinical manifestations and treatment. Expert Rev Gastroenterol Hepatol 3:417–423

    Article  PubMed  Google Scholar 

  49. Krogh K, Christensen P (2009) Neurogenic colorectal and pelvic floor dysfunction. Best Pract Res Clin Gastroenterol 23:531–543

    Article  PubMed  Google Scholar 

  50. Lombardi G, Del Popolo G, Cecconi F, Surrenti E, Macchiarella A (2010) Clinical outcome of sacral neuromodulation in incomplete spinal cord-injured patients suffering from neurogenic bowel dysfunctions. Spinal Cord 48:154–159

    Article  PubMed  CAS  Google Scholar 

  51. Gstaltner K, Rosen H, Hufgard J, Märk R, Schrei K (2008) Sacral nerve stimulation as an option for the treatment of faecal incontinence in patients suffering from cauda equina syndrome. Spinal Cord 46:644–647

    Article  PubMed  CAS  Google Scholar 

  52. Ganio E, Luc AR, Clerico G, Trompetto M (2001) Sacral nerve stimulation for treatment of fecal incontinence: a novel approach for intractable fecal incontinence. Dis Colon Rectum 44:619–629

    Article  PubMed  CAS  Google Scholar 

  53. Rosen HR, Urbarz C, Holzer B, Novi G, Schiessel R (2001) Sacral nerve stimulation as a treatment for fecal incontinence. Gastroenterology 121:536–541

    Article  PubMed  CAS  Google Scholar 

  54. Holzer B, Rosen HR, Novi G, Ausch C, Hölbling N, Schiessel R (2007) Sacral nerve stimulation for neurogenic faecal incontinence. Br J Surg 94:749–753

    Article  PubMed  CAS  Google Scholar 

  55. Jarrett ME, Matzel KE, Christiansen J, Baeten CG, Rosen H, Bittorf B, Stösser M, Madoff R, Kamm MA (2005) Sacral nerve stimulation for faecal incontinence in patients with previous partial spinal injury including disc prolapse. Br J Surg 92:734–739

    Article  PubMed  CAS  Google Scholar 

  56. Horrocks EJ, Thin N, Thaha MA, Taylor SJ, Norton C, Knowles CH (2014) Systematic review of tibial nerve stimulation to treat faecal incontinence. Br J Surg. doi:10.1002/bjs.9391

    PubMed  Google Scholar 

  57. Leroi AM, Siproudhis L, Etienney I, Damon H, Zerbib F, Amarenco G, Vitton V, Faucheron JL, Thomas C, Mion F, Roumeguère P, Gourcerol G, Bouvier M, Lallouche K, Menard JF, Queralto M (2012) Transcutaneous electrical tibial nerve stimulation in the treatment of fecal incontinence: a randomized trial (CONSORT 1a). Am J Gastroenterol 107:1888–1896

    Article  PubMed  CAS  Google Scholar 

  58. Mentes BB, Yüksel O, Aydin A, Tezcaner T, Leventoğlu A, Aytaç B (2007) Posterior tibial nerve stimulation for faecal incontinence after partial spinal injury: preliminary report. Tech Coloproctol 11:115–119

    Article  PubMed  CAS  Google Scholar 

  59. Brindley GS, Rushton DN (1990) Long-term follow-up of patients with sacral anterior root stimulator implants. Paraplegia 28:469–475

    Article  PubMed  CAS  Google Scholar 

  60. Creasey GH, Grill JH, Korsten M, U HS, Betz R, Anderson R, Walter J, Implanted Neuroprosthesis Research Group (2001) An implantable neuroprosthesis for restoring bladder and bowel control to patients with spinal cord injuries: a multicenter trial. Arch Phys Med Rehabil 82:1512–1519

    Article  PubMed  CAS  Google Scholar 

  61. Vallès M, Rodríguez A, Borau A, Mearin F (2009) Effect of sacral anterior root stimulator on bowel dysfunction in patients with spinal cord injury. Dis Colon Rectum 52:986–992

    Article  PubMed  Google Scholar 

  62. Vastenholt JM, Snoek GJ, Buschman HP, van der Aa HE, Alleman ER, Ijzerman MJ (2003) A 7-year follow-up of sacral anterior root stimulation for bladder control in patients with a spinal cord injury: quality of life and users’ experiences. Spinal Cord 41:397–402

    Article  PubMed  CAS  Google Scholar 

  63. Furlan JC, Urbach DR, Fehlings MG (2007) Optimal treatment for severe neurogenic bowel dysfunction after chronic spinal cord injury: a decision analysis. Br J Surg 94:1139–1150

    Article  PubMed  CAS  Google Scholar 

  64. Stöhrer M, Blok B, Castro-Diaz D, Chartier-Kastler E, Del Popolo G, Kramer G, Pannek J, Radziszewski P, Wyndaele JJ (2009) EAU guidelines on neurogenic lower urinary tract dysfunction. Eur Urol 56:81–88

    Article  PubMed  Google Scholar 

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Del Popolo, G., Martellucci, J., Musco, S. (2015). Pelvic Floor Neuromodulation in Neurologic Patients. In: Martellucci, J. (eds) Electrical Stimulation for Pelvic Floor Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-06947-0_19

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