Advertisement

Hemiplegic Migraine

  • Anders Hougaard
  • Messoud AshinaEmail author
Chapter
  • 1.6k Downloads
Part of the Headache book series (HEAD)

Abstract

A 30-year-old woman was admitted to the hospital with suspicion of an acute stroke due to left-sided hemiplegia and right-sided headache. In the ambulance on the way to the hospital, the symptoms gradually disappeared. When asked about her symptoms, she told that she initially had visual disturbances in the form of right-sided flickering lights on the right side of her visual field, where after she gradually had lost all strength in the right side of her body. Fifteen minutes after onset of hemiplegia, the patient developed a severe headache in the left side of the frontal part of the head. The headache was reported as pulsating, the patient became increasingly nauseous and started vomiting, and she further developed hypersensitivity towards lights and sounds.

Keywords

Migraine With Aura Cortical Spreading Depression Sodium Valproate Familial Hemiplegic Migraine Migraine Aura 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Reading

  1. 1.
    Artto V, Nissilä M, Wessman M et al (2007) Treatment of hemiplegic migraine with triptans. Eur J Neurol 14:1053PubMedCrossRefGoogle Scholar
  2. 2.
    Athwal BS, Lennox GG (1996) Acetazolamide responsiveness in familial hemiplegic migraine. Ann Neurol 40:820PubMedCrossRefGoogle Scholar
  3. 3.
    Berg MJ, Williams LS (1995) The transient syndrome of headache with neurologic deficits and CSF lymphocytosis. Neurology 45:1648PubMedCrossRefGoogle Scholar
  4. 4.
    De Fusco M, Marconi R, Silvestri L et al (2003) Haploinsufficiency of ATP1A2 encoding the Na+/K + pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 33:192PubMedCrossRefGoogle Scholar
  5. 5.
    De Vries B, Freilinger T, Vanmolkot KR et al (2007) Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine. Neurology 69:2170PubMedCrossRefGoogle Scholar
  6. 6.
    Dichgans M, Freilinger T, Eckstein G et al (2005) Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 366:371PubMedCrossRefGoogle Scholar
  7. 7.
    Dreier JP, Jurkat-Rott K, Petzold GC et al (2005) Opening of the blood–brain barrier preceding cortical edema in a severe attack of FHM type II. Neurology 64:2145PubMedCrossRefGoogle Scholar
  8. 8.
    Ducros A, Denier C, Joutel A et al (2001) The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. N Engl J Med 345:17PubMedCrossRefGoogle Scholar
  9. 9.
    Gilbert GJ (1982) An occurrence of complicated migraine during propranolol therapy. Headache 22:81PubMedCrossRefGoogle Scholar
  10. 10.
    Hansen JM, Hauge AW, Ashina M, Olesen J (2011) Trigger factors for familial hemiplegic migraine. Cephalalgia 31:1274PubMedCrossRefGoogle Scholar
  11. 11.
    Hansen JM, Schytz HW, Larsen VA et al (2011) Hemiplegic migraine aura begins with cerebral hypoperfusion: imaging in the acute phase. Headache 51:1289PubMedCrossRefGoogle Scholar
  12. 12.
    Hansen JM, Thomsen LL, Olesen J, Ashina M (2010) Coexisting typical migraine in familial hemiplegic migraine. Neurology 74(7):594–600PubMedCrossRefGoogle Scholar
  13. 13.
    Hansen JM, Thomsen LL, Olesen J, Ashina M (2011) Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. Headache 51(4):544–553PubMedCrossRefGoogle Scholar
  14. 14.
    Kaube H, Herzog J, Käufer T et al (2000) Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine. Neurology 55:139PubMedCrossRefGoogle Scholar
  15. 15.
    Lampl C, Katsarava Z, Diener HC, Limmroth V (2005) Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J Neurol Neurosurg Psychiatry 76:1730PubMedCentralPubMedCrossRefGoogle Scholar
  16. 16.
    Lindahl AJ, Allder S, Jefferson D et al (2002) Prolonged hemiplegic migraine associated with unilateral hyperperfusion on perfusion weighted magnetic resonance imaging. J Neurol Neurosurg Psychiatry 73:202PubMedCentralPubMedCrossRefGoogle Scholar
  17. 17.
    Mjåset C, Russell MB (2008) Intravenous nimodipine worsening prolonged attack of familial hemiplegic migraine. J Headache Pain 9:381PubMedCentralPubMedCrossRefGoogle Scholar
  18. 18.
    Mourand I, Menjot de Champfleur N, Carra-Dallière C et al (2012) Perfusion-weighted MR imaging in persistent hemiplegic migraine. Neuroradiology 54:255PubMedCrossRefGoogle Scholar
  19. 19.
    Ophoff RA, Terwindt GM, Vergouwe MN et al (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87:543PubMedCrossRefGoogle Scholar
  20. 20.
    Pelzer N, Stam AH, Carpay JA, Vries BD, van den Maagdenberg AM, Ferrari MD et al (2014) Familial hemiplegic migraine treated by sodium valproate and lamotrigine. Cephalalgia [Epub ahead of print]Google Scholar
  21. 21.
    Pelzer N, Stam AH, Haan J, Ferrari MD, Terwindt GM (2012) Familial and sporadic hemiplegic migraine: diagnosis and treatment. Curr Treat Options Neurol 15(1):13–27CrossRefGoogle Scholar
  22. 22.
    Razavi M, Razavi B, Fattal D et al (2000) Hemiplegic migraine induced by exertion. Arch Neurol 57:1363PubMedGoogle Scholar
  23. 23.
    Russell MB, Ducros A (2011) Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol 10:457PubMedCrossRefGoogle Scholar
  24. 24.
    Thomsen LL, Kirchmann Eriksen M, Faerch Romer S (2002) An epidemiological survey of hemiplegic migraine. Cephalalgia 22:361CrossRefGoogle Scholar
  25. 25.
    Thomsen LL, Olesen J (2004) Sporadic hemiplegic migraine. Cephalalgia 24:1016PubMedCrossRefGoogle Scholar
  26. 26.
    Thomsen LL, Ostergaard E, Olesen J, Russell MB (2003) Evidence for a separate type of migraine with aura: sporadic hemiplegic migraine. Neurology 60:595PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Danish Headache Center and Department of Neurology, Faculty of Health and Medical SciencesGlostrup Hospital, University of CopenhagenGlostrupDenmark

Personalised recommendations