Abstract
The present chapter is advocated to analyzing the dynamics of a simple birth–death process from the perspectives of chemical kinetics, stochastic processes, and thermodynamics. This process is important because, under certain conditions, it constitutes a good model for the numerous biomolecule production/degradation processes taking place within cells. To facilitate the achievement of the above stated goal, a couple of simple stochastic processes are previously introduced and analyzed in detail: the Poisson process and a simple pure death process. The objectives of the present chapter are twofold. On the one hand, we will gain deeper insight into the previous chapter methods, results, and conclusions, by tackling more elaborated examples. But also, the examples here introduced shall serve as building blocks for more realistic cellular-process models to be introduced thereafter. As a bonus, we also introduce and discuss some basic concepts of irreversible thermodynamics in the context of chemical kinetics.
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References
Beard D, Qian H (2008) Chemical biophysics: quantitative analysis of cellular systems. Cambridge Texts in Biomedical Engineering. Cambridge University Press, Cambridge
Cannon WB (1929) Organization for physiological homeostasis. Physiol Rev 9(3):399–431
Evans M, Hastings N, Peacock J (2000) Statistical distributions. Wiley Series in Probability and Statistics. Wiley, New York
Gillespie DT (1977) Exact stochastic simulation of coupled chemical reactions. J Phys Chem 81(25):2340–2361
Lehninger A, Nelson D, Cox M (2005) Lehninger principles of biochemistry. W. H. Freeman, New York
McClure WR (1985) Mechanism and control of transcription initiation in prokaryotes. Ann Rev Biochem 54:171–204
Planck M (1945) Treatise on thermodynamics. Dover Books on Physics Series. Dover Publications, Mineola
Ross SM (1983) Stochastic processes. Wiley Series in Probability and Mathematical Statistics. Wiley, New York
Shahrezaei V, Swain PS (2008) Analytical distributions for stochastic gene expression. Proc Natl Acad Sci 105(45):17,256–17,261
Zeron ES, Santillán M (2010) Distributions for negative-feedback-regulated stochastic gene expression: Dimension reduction and numerical solution of the chemical master equation. J Theor Biol 264(2):377–385
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Santillán, M. (2014). Molecule Synthesis and Degradation. In: Chemical Kinetics, Stochastic Processes, and Irreversible Thermodynamics. Lecture Notes on Mathematical Modelling in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-06689-9_4
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DOI: https://doi.org/10.1007/978-3-319-06689-9_4
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