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Evolution of Transport Directionality in ABCBs

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Plant ABC Transporters

Part of the book series: Signaling and Communication in Plants ((SIGCOMM,volume 22))

Abstract

Plant ATP-binding cassette subfamily B/P-glycoprotein/multidrug resistance (ABCB/PGP/MDR) proteins mediate the transport of a variety aliphatic and amphipathic substrates across the plasma membrane. An unexpected characteristic of some plant ABCBs that is not seen in animal homologs is uptake transport activity. However, in the best studied example of this phenomenon, the ABCB4 auxin transporter is associated with uptake only when intracellular auxin concentrations are low and exhibits canonical efflux activity when internal auxin concentrations increase. Physiological and biochemical characterizations of ABCB4 indicate that the protein serves as a homeostatic regulator and suggest evolutionary origins of the phenomenon. In this chapter we will review early transport studies and the discovery of putative uptake transporters in plants, the functional and structural evolution of these transporters, and what is known about the mechanisms of uptake and conditional uptake/efflux. Further, we will explore issues with homologous or heterologous unicellular systems and how these studies may have led to a mischaracterization of uptake transporters. A re-evaluation of current transport data and new ABCB mediated transport model will also be discussed.

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Authors and Affiliations

  1. Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD, USA

    Mark K. Jenness & Angus S. Murphy

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  1. Mark K. Jenness
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  2. Angus S. Murphy
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Correspondence to Angus S. Murphy .

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Editors and Affiliations

  1. Plant Biology, University of Fribourg Department of Biology, Fribourg, Switzerland

    Markus Geisler

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Jenness, M.K., Murphy, A.S. (2014). Evolution of Transport Directionality in ABCBs. In: Geisler, M. (eds) Plant ABC Transporters. Signaling and Communication in Plants, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-06511-3_14

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