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Myeloablative Single-Unit Cord Blood Transplantation in Adults

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Umbilical Cord Blood Banking and Transplantation

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Umbilical cord blood has several advantages of immediate availability, no risk to donors, and a lower risk for acute and chronic graft-versus-host disease (GVHD) despite major human leukocyte antigen (HLA) disparity. As a result of the early successes with pediatric umbilical cord blood transplantation (UCBT), umbilical cord blood from unrelated donors have been increasingly used as an alternative stem cell source for adult patients with hematologic malignancies. Recent single institute and registry-based studies suggest that UCBT is a safe, feasible, and effective strategy for adult patients without suitable related or unrelated bone marrow donors. In this review, we focus on recent results of single-unit UCBT after myeloablative conditioning in adults.

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Authors and Affiliations

  1. Department of Hematology/Oncology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8606, Tokyo, Japan

    Jun Ooi MD

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  1. Jun Ooi MD
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Correspondence to Jun Ooi MD .

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Editors and Affiliations

  1. Leukemia Program, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Karen Ballen

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Ooi, J. (2014). Myeloablative Single-Unit Cord Blood Transplantation in Adults. In: Ballen, K. (eds) Umbilical Cord Blood Banking and Transplantation. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-06444-4_9

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