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Results of Cord Blood Transplantation in Children with Nonmalignant Hematologic Conditions

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Umbilical Cord Blood Banking and Transplantation

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

The application of cord blood transplantation to children with a variety of life-threatening nonmalignant conditions, including hemoglobinopathies, congenital and acquired bone marrow failure syndromes, and congenital immunodeficiencies will be reviewed. Recent clinical trials utilizing double cord blood transplantation and cell engineering to enhance cord blood engraftment will also be reviewed. Guidelines for donor selection for pediatric recipients vary based on diagnosis, performance status, type of conditioning, and host-related comorbidities. These criteria differ from those traditionally used for adults and will be discussed.

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Authors and Affiliations

  1. Carolinas Cord Blood Bank and Duke University Medical Center, Durham, NC, USA

    Kristin M. Page MD, Suhag Parikh MD & Joanne Kurtzberg MD

Authors
  1. Kristin M. Page MD
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  2. Suhag Parikh MD
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  3. Joanne Kurtzberg MD
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Correspondence to Kristin M. Page MD .

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Editors and Affiliations

  1. Leukemia Program, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Karen Ballen

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© 2014 Springer International Publishing Switzerland

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Page, K., Parikh, S., Kurtzberg, J. (2014). Results of Cord Blood Transplantation in Children with Nonmalignant Hematologic Conditions. In: Ballen, K. (eds) Umbilical Cord Blood Banking and Transplantation. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-06444-4_7

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