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Umbilical Cord Blood Banking and Transplantation pp 235–255Cite as

Comparison of Umbilical Cord Blood to Adult Related and Unrelated Donors

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

The immunologic immaturity of umbilical cord blood (UCB) permits a high degree of human leukocyte antigen (HLA) mismatch, making it an attractive donor option. We compare the clinical outcomes of patients undergoing UCB hematopoietic stem cell transplantation (HSCT) with related and unrelated adult donor transplantations. Retrospective studies have shown similar overall and disease-free survival in patients undergoing related and unrelated donor transplant when compared to those undergoing UCB HSCT. UCB recipients have delayed engraftment and immune reconstitution and higher rates of graft failure, all resulting in higher nonrelapse mortality during the first year posttransplantation. UCB recipients generally have a lower incidence of acute and chronic graft-versus-host disease with at least similar, if not lower relapse rates compared to adult donor counterparts. Strategies to promote engraftment and enhance immune reconstitution will be critical in reducing the transplant-related mortality of UCB.

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Authors and Affiliations

  1. Massachusetts General Hospital, Boston, MA, USA

    Areej El-Jawahri & Yi-Bin Chen

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  1. Areej El-Jawahri
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Correspondence to Yi-Bin Chen .

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Editors and Affiliations

  1. Leukemia Program, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Karen Ballen

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El-Jawahri, A., Chen, YB. (2014). Comparison of Umbilical Cord Blood to Adult Related and Unrelated Donors. In: Ballen, K. (eds) Umbilical Cord Blood Banking and Transplantation. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-06444-4_18

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