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Targeting Homing to Enhance Engraftment Following Umbilical Cord Blood Stem Cell Transplantation

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Umbilical Cord Blood Banking and Transplantation

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Umbilical cord blood (UCB) offers an important alternative source of hematopoietic stem cells for a large population of patients who cannot locate an adult donor on a registry. However, a major weakness of transplant with UCB is delayed engraftment related to the relatively low stem cell dose found in UCB. This chapter explores the targeting of stem cell homing to the bone marrow as means to enhance engraftment. A number of approaches, including ex vivo fucosylation of UCB cells, ex vivo priming with prostaglandin E2, ex vivo priming with complement fragment 3a, and systemic inhibition of CD26/dipeptidyl peptidase (DPP)-IV. These promising approaches offer the potential of improving the outcome of UCB transplantation and extending the potentially curative modality of allogeneic stem cell transplantation to more adults with hematologic malignancies.

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Acknowledgements

This work was partly supported by grants from the V Foundation for Cancer Research, and Public Service R01HL112669 from the National Institutes of Health (NIH) of the USA.

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Medicine and Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA

    Sherif S. Farag MD, PhD & Tyler Davis MD

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  1. Sherif S. Farag MD, PhD
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  2. Tyler Davis MD
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Correspondence to Sherif S. Farag MD, PhD .

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  1. Leukemia Program, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Karen Ballen

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Farag, S., Davis, T. (2014). Targeting Homing to Enhance Engraftment Following Umbilical Cord Blood Stem Cell Transplantation. In: Ballen, K. (eds) Umbilical Cord Blood Banking and Transplantation. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-06444-4_13

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