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New Developments in Food Safety Assessment: Innovations in Food Allergy and Toxicological Safety Assessment

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Pharma-Nutrition

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 12))

Abstract

Food preferably has to be tasteful, healthy, attractive, and affordable, but should above all be safe. The safety of our daily food nowadays is at a reasonable level, but is far from obvious. During the past half century, food risk assessment and risk management approaches have developed. Yet, several white spots or areas of inefficiency still exist. In this chapter, recent and ongoing innovations in two areas are addressed: innovations in food allergy safety assessment and innovations in toxicological safety assessment of food. Regarding food allergy safety assessment, the development of risk assessment-based guidance on precautionary labeling is addressed as well as strategies for assessment of the allergenicity of novel food proteins, either from genetically modified (GM) or non-GM origin. Regarding the toxicological safety assessment of food, an innovative new toxicological safety assessment approach for complex food matrices based on the Threshold of Toxicological Concern concept is presented and discussed.

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References

  1. Sampson HA, Burks AW (1996) Mechanisms of food allergy. Annu Rev Nutr 16:161–177

    Article  CAS  PubMed  Google Scholar 

  2. Sampson HA (2004) Update on food allergy. J Allergy Clin Immunol 113(5):805–819

    Article  CAS  PubMed  Google Scholar 

  3. Gould HJ, Sutton BJ, Beavil AJ, Beavil RL, McCloskey N, Coker HA et al (2003) The biology of IGE and the basis of allergic disease. Annu Rev Immunol 21:579–628

    Article  CAS  PubMed  Google Scholar 

  4. Eigenmann PA, Beyer K, Wesley BA, Lack G, Liacouras CA, Hourihane JO et al (2008) New visions for food allergy: an iPAC summary and future trends. Pediatr Allergy Immunol 19(Suppl 19):26–39

    Article  PubMed  Google Scholar 

  5. Kagan RS, Joseph L, Dufresne C, Gray-Donald K, Turnbull E, Pierre YS et al (2003) Prevalence of peanut allergy in primary-school children in Montreal, Canada. J Allergy Clin Immunol 112(6):1223–1228

    Article  PubMed  Google Scholar 

  6. Roehr CC, Edenharter G, Reimann S, Ehlers I, Worm M, Zuberbier T et al (2004) Food allergy and non-allergic food hypersensitivity in children and adolescents. Clin Exp Allergy 34(10):1534–1541

    Article  CAS  PubMed  Google Scholar 

  7. Prescott S, Allen KJ (2011) Food allergy: riding the second wave of the allergy epidemic. Pediatr Allergy Immunol 22(2):155–160

    Article  PubMed  Google Scholar 

  8. Nauta AJ, Engels F, Knippels LM, Garssen J, Nijkamp FP, Redegeld FA (2008) Mechanisms of allergy and asthma. Eur J Pharmacol 585(2–3):354–360

    Article  CAS  PubMed  Google Scholar 

  9. Berin MC, Mayer L (2009) Immunophysiology of experimental food allergy. Mucosal Immunol 2(1):24–32

    Article  CAS  PubMed  Google Scholar 

  10. Eigenmann PA (2009) Mechanisms of food allergy. Pediatr Allergy Immunol 20(1):5–11

    Article  PubMed  Google Scholar 

  11. Metcalfe DD, Astwood JD, Townsend R, Sampson HA, Taylor SL, Fuchs RL (1996) Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit Rev Food Sci Nutr 36(Suppl):S165–S186

    Article  CAS  PubMed  Google Scholar 

  12. Radauer C, Bublin M, Wagner S, Mari A, Breiteneder H (2008) Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J Allergy Clin Immunol 121(4):847–852

    Article  CAS  PubMed  Google Scholar 

  13. NIAID-Sponsored Expert Panel, Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA et al (2010) Guidelines for the diagnosis and management of food allergy in the United States: Report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 126(6 Suppl):S1–S58

    PubMed  Google Scholar 

  14. Selgrade MK, Bowman CC, Ladics GS, Privalle L, Laessig SA (2009) Safety assessment of biotechnology products for potential risk of food allergy: implications of new research. Toxicol Sci 110(1):31–39

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Malmheden Yman I (2004) Detection of inadequate labelling and contamination as causes of allergic reactions to food. Acta Aliment 33(4):347–357

    Article  Google Scholar 

  16. Boyano-Martínez T, García-Ara C, Pedrosa M, Díaz-Pena JM, Quirce S (2009) Accidental allergic reactions in children allergic to cow’s milk proteins. J Allergy Clin Immunol 123(4):883–888

    Article  PubMed  Google Scholar 

  17. Sheth SS, Waserman S, Kagan R, Alizadehfar R, Primeau MN, Elliot S et al (2010) Role of food labels in accidental exposures in food-allergic individuals in Canada. Ann Allergy Asthma Immunol 104(1):60–65

    Article  PubMed  Google Scholar 

  18. Spanjersberg MQ, Kruizinga AG, Rennen MA, Houben GF (2007) Risk assessment and food allergy: the probabilistic model applied to allergens. Food Chem Toxicol 45(1):49–54

    Article  CAS  PubMed  Google Scholar 

  19. Pele M, Brohee M, Anklam E, van Hengel AJ (2007) Peanut and hazelnut traces in cookies and chocolates: relationship between analytical results and declaration of food allergens on product labels. Food Addit Contam 24(12):1334–1344

    Article  CAS  PubMed  Google Scholar 

  20. Spanjersberg MQ, Knulst AC, Kruizinga AG, Van DG, Houben GF (2010) Concentrations of undeclared allergens in food products can reach levels that are relevant for public health. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27(2):169–174

    Article  CAS  PubMed  Google Scholar 

  21. Hefle SL, Furlong TJ, Niemann L, Lemon-Mule H, Sicherer S, Taylor SL (2007) Consumer attitudes and risks associated with packaged foods having advisory labeling regarding the presence of peanuts. J Allergy Clin Immunol 120(1):171–176

    Article  PubMed  Google Scholar 

  22. Noimark L, Gardner J, Warner JO (2009) Parents’ attitudes when purchasing products for children with nut allergy: a UK perspective. Pediatr Allergy Immunol 20(5):500–504

    Article  CAS  PubMed  Google Scholar 

  23. Madsen CB, Hattersley S, Buck J, Gendel SM, Houben GF, Hourihane JO et al (2009) Approaches to risk assessment in food allergy: report from a workshop “developing a framework for assessing the risk from allergenic foods”. Food Chem Toxicol 47(2):480–489

    Article  CAS  PubMed  Google Scholar 

  24. Kerbach S, Alldrick AJ, Crevel R, Domotor L, DunnGalvin A, Mills ENC et al (2009) Managing food allergens in the food supply chain-viewed from different stakeholder perspectives. Qual Assur Safety Crops Foods 1:50–60

    Article  Google Scholar 

  25. Allergen Bureau (2010) Allergen bureau labelling review survey 2009. Food Aust 62(8):344–345

    Google Scholar 

  26. Wensing M, Penninks AH, Hefle SL, Koppelman SJ, Bruijnzeel-Koomen CA, Knulst AC (2002) The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy. J Allergy Clin Immunol 110(6):915–920

    Article  PubMed  Google Scholar 

  27. Wensing M, Penninks AH, Hefle SL, Akkerdaas JH, van Ree R, Koppelman SJ et al (2002) The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges. Clin Exp Allergy 32(12):1757–1762

    Article  CAS  PubMed  Google Scholar 

  28. Bindslev-Jensen C, Briggs D, Osterballe M (2002) Can we determine a threshold level for allergenic foods by statistical analysis of published data in the literature? Allergy 57(8):741–746

    Article  CAS  PubMed  Google Scholar 

  29. Taylor SL, Hefle SL, Bindslev-Jensen C, Atkins FM, Andre C, Bruijnzeel-Koomen C et al (2004) A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much? Clin Exp Allergy 34(5):689–695

    Article  CAS  PubMed  Google Scholar 

  30. Gendel S, Buchanan R, Dennis S, Acheson D, Assimon SA, Beru N et al (2008) Approaches to establish thresholds for major food allergens and for gluten in food. J Food Protect 71(5):1043–1088

    Google Scholar 

  31. Taylor SL, Crevel RW, Sheffield D, Kabourek J, Baumert J (2009) Threshold dose for peanut: risk characterization based upon published results from challenges of peanut-allergic individuals. Food Chem Toxicol 47(6):1198–1204

    Article  CAS  PubMed  Google Scholar 

  32. Blom WM, Vlieg-Boerstra BJ, Kruizinga AG, Van Der Heide S, Houben GF, Dubois AEJ (2013) Threshold dose distributions for 5 major allergenic foods in children. J Allergy Clin Immunol 131(1):172–179

    Article  CAS  PubMed  Google Scholar 

  33. Taylor SL, Baumert JL, Kruizinga AG, Remington BC, Crevel RWR, Brooke-Taylor S, Allen KJ, The Allergy Bureau of Australia & New Zealand, Houben GF (2014) Establishment of reference doses for residues of allergenic foods: report of the VITAL Expert Panel. Food Chem Toxicol 63:9–17

    Article  CAS  PubMed  Google Scholar 

  34. Frewer L, Lassen J, Kettlitz B, Scholderer J, Beekman V, Berdal KG (2004) Societal aspects of genetically modified foods. Food Chem Toxicol 42(7):1181–1193

    Article  CAS  PubMed  Google Scholar 

  35. Frewer LJ, Scholderer J, Bredahl L (2003) Communicating about the risks and benefits of genetically modified foods: the mediating role of trust. Risk Anal 23(6):1117–1133

    Article  PubMed  Google Scholar 

  36. Aalberse RC, Stadler BM (2006) In silico predictability of allergenicity: from amino acid sequence via 3-D structure to allergenicity. Mol Nutr Food Res 50(7):625–627

    Article  CAS  PubMed  Google Scholar 

  37. Ladics GS, Cressman RF, Herouet-Guicheney C, Herman RA, Privalle L, Song P et al (2011) Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations. Regul Toxicol Pharmacol 60(1):46–53

    Article  PubMed  Google Scholar 

  38. FAO/WHO (2001) Report of joint FAO/WHO expert consultation on foods derived from biotechnology, 22–25 Jan 2001

    Google Scholar 

  39. EFSA Panel of Genetically Modified Organisms (2010) Scientific opinion on the assessment of allergenicity of GM plants and microorganisms and derived food and feed. EFSA J 8(7):1700

    Google Scholar 

  40. Gubesch M, Theler B, Dutta M, Baumer B, Mathis A, Holzhauser T et al (2007) Strategy for allergenicity assessment of ‘natural novel foods’: clinical and molecular investigation of exotic vegetables (water spinach, hyacinth bean and Ethiopian eggplant). Allergy 62(11):1243–1250

    Article  CAS  PubMed  Google Scholar 

  41. Hauser M, Roulias A, Ferreira F, Egger M (2010) Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol 6(1):1. doi:10.1186/1710-1492-6-1

    Article  PubMed Central  PubMed  Google Scholar 

  42. James LC, Roversi P, Tawfik DS (2003) Antibody multispecificity mediated by conformational diversity. Science 299(5611):1362–1367

    Article  CAS  PubMed  Google Scholar 

  43. Bohle B (2007) The impact of pollen-related food allergens on pollen allergy. Allergy 62(1):3–10

    Article  CAS  PubMed  Google Scholar 

  44. Scheurer S, Wangorsch A, Nerkamp J, Skov PS, Ballmer-Weber B, Wuthrich B et al (2001) Cross-reactivity within the profilin panallergen family investigated by comparison of recombinant profilins from pear (pyr c 4), cherry (pru av 4) and celery (api g 4) with birch pollen profilin bet v 2. J Chromatogr B Biomed Sci Appl 756(1–2):315–325

    Article  CAS  PubMed  Google Scholar 

  45. Nakamura R, Matsuda T (1996) Rice allergenic protein and molecular-genetic approach for hypoallergenic rice. Biosci Biotechnol Biochem 60(8):1215–1221

    Article  CAS  PubMed  Google Scholar 

  46. Herman EM, Helm RM, Jung R, Kinney AJ (2003) Genetic modification removes an immunodominant allergen from soybean. Plant Physiol 132(1):36–43

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  47. Gilissen LJ, Bolhaar ST, Matos CI, Rouwendal GJ, Boone MJ, Krens FA et al (2005) Silencing the major apple allergen mal d 1 by using the RNA interference approach. J Allergy Clin Immunol 115(2):364–369

    Article  CAS  PubMed  Google Scholar 

  48. Dodo H, Konan K, Viquez O (2005) A genetic engineering strategy to eliminate peanut allergy. Curr Allergy Asthma Rep 5(1):67–73

    Article  CAS  PubMed  Google Scholar 

  49. Lorenz Y, Enrique E, Lequynh L, Fotisch K, Retzek M, Biemelt S et al (2006) Skin prick tests reveal stable and heritable reduction of allergenic potency of gene-silenced tomato fruits. J Allergy Clin Immunol 118(3):711–718

    Article  CAS  PubMed  Google Scholar 

  50. Davis PJ, Smales CM, James DC (2001) How can thermal processing modify the antigenicity of proteins? Allergy 56(Suppl 67):56–60

    Article  PubMed  Google Scholar 

  51. van Bilsen JH, Ronsmans S, Crevel RW, Rona RJ, Przyrembel H, Penninks AH et al (2011) Evaluation of scientific criteria for identifying allergenic foods of public health importance. Regul Toxicol Pharmacol 60(3):281–289

    Article  PubMed  Google Scholar 

  52. Björksten B, Crevel R, Hischenhuber C, Lovik M, Samuels F, Strobel S et al (2008) Criteria for identifying allergenic foods of public health importance. Regul Toxicol Pharmacol 51(1):42–52

    Article  PubMed  Google Scholar 

  53. Kroes R, Galli CL, Munro I, Schilter B, Tran L-A, Walker R, Würtzen G (2000) Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing. Food Chem Toxicol 38:255–312

    Article  CAS  PubMed  Google Scholar 

  54. Kroes R, Renwick AG, Cheeseman M, Kleiner J, Mangelsdorf I, Piersma A, Schilter B, Schlatter J, van Schothorst F, Vos JG, Würtzen G (2004) Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet. Food Chem Toxicol 42:65–83

    Article  CAS  PubMed  Google Scholar 

  55. Kroes R, Kleiner J, Renwick A (2005) The threshold of toxicological concern concept in risk assessment. Toxicol Sci 86(2):226–230

    Article  CAS  PubMed  Google Scholar 

  56. Renwick A (2004) Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents. Toxicol Lett 149:223–234

    Article  CAS  PubMed  Google Scholar 

  57. Renwick A (2005) Structure-based thresholds of toxicological concern—guidance for application to substances present at low levels in the diet. Toxicol Appl Pharmacol 207:585–591

    Article  CAS  PubMed  Google Scholar 

  58. Munro IC, Renwick AG, Danielewska-Nikiel B (2008) The Threshold of Toxicological Concern (TTC) in risk assessment. Toxicol Lett 180:151–156

    Article  CAS  PubMed  Google Scholar 

  59. EFSA (2012) Scientific opinion on exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC). EFSA J 10(7):2750

    Google Scholar 

  60. US FDA (1995) US Food and Drug Administration. Food additives: threshold of regulation for substances used in food-contact articles; final rule. Fed Regist 60:36582–36596, July 17

    Google Scholar 

  61. JECFA (1997) Evaluation of certain food additives and contaminants. Forty-Sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO Technical Report Series (TRS) No. 868

    Google Scholar 

  62. Müller L, Mauthe RJ, Riley CM, Andino MM, De Antonis D, Beels C, DeGeorge J, De Knaep AGM, Ellison D, Fagerland JA, Frank R, Fritschel B, Galloway S, Harpur E, Humfrey CDN, Jacks AS, Jagota N, Mackinnon J, Mohan G, Ness DK, O’Donovan MR, Smith MD, Vudathala G, Yotti L (2006) A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity. Regul Toxicol Pharmacol 44:198–211

    Article  PubMed  Google Scholar 

  63. Carthew P, Clapp C, Gutsell S (2009) Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products. Food Chem Toxicol 47:1287–1295

    Article  CAS  PubMed  Google Scholar 

  64. Rennen MAJ, Koster S, Krul CAM, Houben GF (2011) Application of the threshold of toxicological concern (TTC) concept to the safety assessment of chemically complex food matrices. Food Chem Toxicol 49(4):933–940

    Article  CAS  PubMed  Google Scholar 

  65. Koster S, Boobis AR, Cubberley R, Hollnagel HM, Richling E, Wildemann T, Würtzen G, Galli CL (2011) Application of the TTC concept to unknown substances found in analysis of foods. Food Chem Toxicol 49:1643–1660

    Article  CAS  PubMed  Google Scholar 

  66. Hughes C et al (2012) Development of a high-throughput Gaussia luciferase reporter assay for the activation of the GADD45a gene by mutagens, promutagens, clastogens, and aneugens. J Biomol Screen 17(10):1302–1315

    Article  PubMed  Google Scholar 

  67. Pieters MN, Kőnneman WH (1997) Toxicology of mixtures: a review of the safety factor of 100 applied in the safety evaluation of chemical mixtures. Dutch National Institute for Public Health and Environment (RIVM), Report number 620110004, Bilthoven, The Netherlands

    Google Scholar 

  68. Boobis A (2009) Critical analysis of literature on low dose synergy for use of TTC in screening chemical mixtures for risk assessment. Toxicol Lett 189–1:S51

    Article  Google Scholar 

  69. Leeman WR, Krul L, Houben GF (2013) Complex mixtures: relevance of combined exposure to substances at low dose levels. Food Chem Toxicol 58:141–148

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. TNO, 3704 HE, Zeist, The Netherlands

    Geert Houben, Marty Blom, Jolanda van Bilsen & Lisette Krul

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  1. Geert Houben
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  2. Marty Blom
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  3. Jolanda van Bilsen
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  4. Lisette Krul
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Correspondence to Geert Houben .

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Editors and Affiliations

  1. Pharmacology, Utrecht University, The Netherlands

    Gert Folkerts

  2. Immunopharmacology, Utrecht University, The Netherlands

    Johan Garssen

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Houben, G., Blom, M., van Bilsen, J., Krul, L. (2014). New Developments in Food Safety Assessment: Innovations in Food Allergy and Toxicological Safety Assessment. In: Folkerts, G., Garssen, J. (eds) Pharma-Nutrition. AAPS Advances in the Pharmaceutical Sciences Series, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-06151-1_2

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