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Expression of the Potentially Immunogenic Truncated Glycoprotein E2 (From Viral Bovine Diarrhoea Virus) in Nicotiana tabacum

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Plant Biotechnology for Health

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Abstract

Viral Bovine Diarrhoea (VBD) is a contagious infection disease caused by the viral bovine diarrhoea virus (BVDV) producing high economic losses for its effects in the respiratory and reproductive system. Besides bovines, BVDV also affects sheep, goats, and wild ruminants, which are potential reservoirs of the virus.

The main purpose of a program for controlling BVDV should be the prevention of the foetal infections, avoiding the birth of persistently infected animals (PIA), and preventing acute infections. Those goals can be achieved preventing the exposure to the virus by removing the PIA from the herd, and by increasing the immunity to BVDV through vaccination.

The glycoprotein E2, as the principal immunogen of the BVDV, is the main target for neutralizing antibodies. In the last decade, studies were performed to develop vaccines with a recombinant E2 of prokaryotic and eukaryotic origin. E2 was expressed in E. coli, mammal’s cells through the vaccinia system, insect cells and plants. In insect cells and plants the E2 expressed was able to induce specific neutralizing antibodies being potential production platforms for the development of a new generation of vaccines.

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  1. School of Pharmacy and Biochemistry, CONICET/Universidad Maimónides, Buenos Aires, Argentina

    María Alejandra Alvarez

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Alvarez, M.A. (2014). Expression of the Potentially Immunogenic Truncated Glycoprotein E2 (From Viral Bovine Diarrhoea Virus) in Nicotiana tabacum . In: Plant Biotechnology for Health. Springer, Cham. https://doi.org/10.1007/978-3-319-05771-2_8

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