Skip to main content
SpringerLink
Log in

Inflammation

  • Chapter
  • First Online:
Positron Emission Tomography with Computed Tomography (PET/CT)

  • 2019 Accesses

Abstract

This is a 40-year-old female with multiple lymphadenopathies in the neck. Biopsy shows necrotizing histiocytic lymphadenitis compatible with Kikuchi-Fujimoto’s lymphadenopathy. Initial PET/CT scan shows hypermetabolic and enlarged right internal jugular and right submandibular lymph nodes (Fig. 5.1). Chemotherapy is given and after 1 cycle a follow-up PET/CT (after 7 months) shows regression to almost complete resolution of the initial lymphadenopathies (Fig. 5.2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Brown JR, Skarin AT. Clinical mimics of lymphoma. Oncologist. 2004;9(4):406–16.

    Article  PubMed  Google Scholar 

  2. Bosch X, Guilabert A. Kikuchi-Fujimoto disease. Orphanet J Rare Dis. 2006;1:18.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Shih-Hin C, Wen-Yu C, Ting-Jung W. Kikuchi disease caused intense cervical lymph nodes FDG uptake in a patient with choriocarcinoma. Ann Nucl Med Sci. 2010;23:221–5.

    Google Scholar 

  4. Lipsky PE. Rheumatoid arthritis (n.d.). Retrieved from http://www.mhprofessional.com/downloads/products/0071741437/fauci_rheumatology_ch05_082-099.pdf.

  5. Kubota R, Yamada S, Kubota K, et al. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med. 1992;33:1972–80.

    CAS  PubMed  Google Scholar 

  6. Metser U, Miller E, Lerman H, Even-Sapir E. Benign non-physiologic lesions with increased 18F-FDG uptake on PET/CT: characterization and incidence. Am J Roentgenol. 2007;189:1203–10.

    Article  Google Scholar 

  7. Zhao S, Kuge Y, Nakada K, Mochizuki T, et al. Effect of steroids on [18F]fluorodeoxyglucose uptake in an experimental tumour model. Nucl Med Commun. 2004;25:727–30.

    Article  CAS  PubMed  Google Scholar 

  8. Kerr GS, Hallahan CW, Giordano J, et al. Takayasu arteritis. Ann Intern Med. 1994;120:919–29.

    Article  CAS  PubMed  Google Scholar 

  9. Sharma BK, Iliskovic NS, Singal PK. Takayasu’s arteritis may be underdiagnosed in North America. Can J Cardiol. 1995;11:311–6.

    CAS  PubMed  Google Scholar 

  10. Webb M, Chambers A, AL-Nahhas A, et al. The role of FDG-PET in characterizing disease activity in Takayasu arteritis. Eur J Nucl Med Mol Imaging. 2004;31:627–34.

    Article  PubMed  Google Scholar 

  11. Papathanasiou ND, Du Y, Menezes LJ, et al. Fluorodeoxyglucose PET/CT in the evaluation of large vessel vasculitis: diagnostic performance and correlation with clinical and laboratory parameters. Br J Radiol. 2012;85:e188–94.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Palestro CJ. Invited commentary: nuclear medicine, the painful prosthetic joint and orthopedic infection. J Nucl Med. 2003;44:927–9.

    PubMed  Google Scholar 

  13. Zhuang H, Duarte PS, Pourdehnad M, et al. The promising role of FDG PET in detecting infected lower limb prosthesis implants. J Nucl Med. 2001;42:44–8.

    CAS  PubMed  Google Scholar 

  14. Parsons RW, Thering HR. Management of the silicone-injected breast. Plast Reconstr Surg. 1977;60(4):534–8.

    Article  CAS  PubMed  Google Scholar 

  15. Willis MT. Silicone injections make a comeback. In: ABC News. Retrieved from http://abcnews.go.com/Health/story?id=116825. 2013.

  16. Rosen PP. Rosen’s breast pathology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2008.

    Google Scholar 

  17. Chen CJ, Lee BF, Yao WJ, et al. False positive 18F-FDG PET/CT scan caused by breast silicone injection. Korean J Radiol. 2009;10(2):194–6.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Vang R, Gown AM, Barry TS, et al. Ovarian atypical proliferative (borderline) mucinous tumors: gastrointestinal and seromucinous (endocervical-like) types are immunophenotypically distinctive. Int J Gynecol Pathol. 2006;25(1):83–9.

    Article  PubMed  Google Scholar 

  19. Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ. Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas. Am J Surg Pathol. 2002;26(12):1529–41.

    Article  PubMed  Google Scholar 

  20. Wound healing. In: Wikipedia, the free encyclopedia. Retrieved from http://en.wikipedia.org/wiki/Wound_healing. Accessed 24 Dec 2013.

  21. Shreve PD, Anzai Y, Wahl RL. Pitfalls in oncologic diagnosis with FDG PET imaging: physiologic and benign variants. Radiographics. 1999;19:61–77.

    Article  CAS  PubMed  Google Scholar 

  22. Liver abscess. 2012. In: Clinical key. Elsevier. Retrieved from https://www.clinicalkey.com/topics/gastroenterology/liver-abscess.html.

  23. Metser U, Even-Sapir E. Increased fluorodeoxyglucose uptake in benign non-physiologic lesions found on whole body PET/CT: accumulated data from four years of experience with PET/CT. Semin Nucl Med. 2007;37:206–22.

    Article  PubMed  Google Scholar 

  24. Cavailloles FA, Mure A, Nasser H, et al. Multiple liver amebic abscesses detected on FDG PET/CT. Clin Nucl Med. 2013. Retrieved from www.ncbi.nlm.nih.gov/pubmed/23640216.

  25. Ichiya Y, Kuwabara Y, Sasaki M, et al. FDG-PET in infectious lesions: the detection and assessment of lesion activity. Ann Nucl Med. 1996;10(2):185–91.

    Article  CAS  PubMed  Google Scholar 

  26. Delbeke D, Martin WH, Sandler MP, et al. Evaluation of benign vs malignant hepatic lesions with positron emission tomography. Arch Surg. 1998;133:510–6.

    Article  CAS  PubMed  Google Scholar 

  27. Kumar R, Loving VA, Chauhan A, et al. Potential of dual-time-point imaging to improve breast cancer diagnosis with 18F-FDG PET. J Nucl Med. 2005;46:1819–24.

    PubMed  Google Scholar 

  28. Macdonald K, Searle J, Lyburn I. The role of dual time point FDG PET imaging in the evaluation of solitary pulmonary nodules with an initial standard uptake value less than 2.5. Clin Radiol. 2011;66(3):244–50.

    Article  CAS  PubMed  Google Scholar 

  29. Chan WL, Ramsay SC, Szeto ER, et al. Dual-time-point (18)F-FDG-PET/CT imaging in the assessment of suspected malignancy. J Med Imaging Radiat Oncol. 2011;55(4):379–90.

    Article  PubMed  Google Scholar 

  30. Nanni C, Marzola MC, Rubello D, et al. Positron emission tomography for the evaluation of soft tissue sarcomas and bone sarcomas. Eur J Nucl Med Mol Imaging. 2009;36:1940–3.

    Article  PubMed  Google Scholar 

  31. Brenner W, Eary JF, Hwang W, et al. Risk assessment in liposarcoma patients based on FDG PET imaging. Eur J Nucl Med Mol Imaging. 2006;33(11):1290–5.

    Article  PubMed  Google Scholar 

  32. Ioannidis JPA, Lau J. F18 FDG PET for the diagnosis and grading of soft tissue sarcoma: a meta analysis. J Nucl Med. 2003;44:717–24.

    PubMed  Google Scholar 

  33. Nakagawa T, Yamada M, Suzuki Y. Fluorine −18 FDG uptake in reactive lymph nodes of oral cancer: relation to lymphoid follicles. J Nucl Med. 2008;49:1053–9.

    Article  PubMed  Google Scholar 

  34. Chung JH, Cho KJ, Lee SS, et al. Overexpression of GLUT1 in lymphoid follicles correlates with false-positive F-18 FDG PET results in lung cancer staging. J Nucl Med. 2004;45:999–1003.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and PET Center, St. Luke’s Medical Center, Taguig City, MM, Philippines

    Jonas Francisco Y. Santiago

Authors
  1. Jonas Francisco Y. Santiago
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Santiago, J.F.Y. (2015). Inflammation. In: Positron Emission Tomography with Computed Tomography (PET/CT). Springer, Cham. https://doi.org/10.1007/978-3-319-05518-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-05518-3_5

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-05517-6

  • Online ISBN: 978-3-319-05518-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation