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Mammalian Transient Receptor Potential (TRP) Cation Channels pp 917–933Cite as

TRPs in Olfaction

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 223))

Abstract

The mammalian olfactory system has become an excellent model system to understand the function of transient receptor potential (TRP) channels within their native cellular and circuit environment. The discovery that the canonical TRP channel TRPC2 is highly expressed in sensory neurons of the vomeronasal organ (VNO) has led to major advances in our understanding of the cellular and molecular processes underlying signal transduction of pheromones and other molecular cues that play an essential role in the control of instinctive decisions and innate social behaviors. TRPC2 knockout mice provide a striking example that the loss of function of a single gene can cause severe alterations in a variety of social interactions including the display of aggression, social dominance, and sexual behaviors. There is mounting evidence that TRPC2 is not the only TRP channel expressed in cells of the olfactory system but that other TRP channel subtypes such as TRPC1, TRPC4, TRPC6, TRPM4, and TRPM5 could also play important functional roles in mammalian olfaction. Here, I review such findings and discuss future areas for investigation.

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Acknowledgments

Work in the author’s laboratory is supported by Deutsche Forschungsgemeinschaft grants Sonderforschungsbereich 894, Schwerpunktprogramm 1392, and Graduiertenkolleg 1362 and by the National Institutes of Health (DC005633).

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The author declares that he has no conflict of interest.

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  1. Department of Physiology and Center for Integrative Physiology and Molecular Medicine, University of Saarland School of Medicine, 66424, Homburg, Germany

    Frank Zufall

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Correspondence to Frank Zufall .

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  1. Laboratory Ion Channel Research, Campus Gasthuisberg, KU Leuven Department, Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Pharmakologie und Toxikologie, Universität des Saarlandes, Institut für Experimentelle u. Klinische, Homburg, Germany

    Veit Flockerzi

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Zufall, F. (2014). TRPs in Olfaction. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 223. Springer, Cham. https://doi.org/10.1007/978-3-319-05161-1_8

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