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TRPs in Hearing

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Mammalian Transient Receptor Potential (TRP) Cation Channels

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 223))

Abstract

Hearing is a particularly sensitive form of mechanosensation that relies on dedicated ion channels transducing sound-induced vibrations that hardly exceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears. In Drosophila, hearing has been shown to involve TRPA, TRPC, TRPN, and TRPV subfamily members, with candidate auditory transduction channels including NOMPC (=TRPN1) and the TRPVs Nan and Iav. In vertebrates, TRPs are unlikely to form auditory transduction channels, yet most TRPs are expressed in inner ear tissues, and mutations in TRPN1, TRPVA1, TRPML3, TRPV4, and TRPC3/TRPC6 have been implicated in inner ear function. Starting with a brief introduction of fly and vertebrate auditory anatomies and transduction mechanisms, this review summarizes our current understanding of the auditory roles of TRPs.

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Authors and Affiliations

  1. Department of Cellular Neurobiology, University of Göttingen, Julia-Lermontowa-Weg 3, 37077, Göttingen, Germany

    Damiano Zanini & Martin C. Göpfert

  2. DFG Priority Program 1608 and Collaborative Research Center 889, Göttingen, Germany

    Damiano Zanini & Martin C. Göpfert

Authors
  1. Damiano Zanini
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  2. Martin C. Göpfert
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Correspondence to Martin C. Göpfert .

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Editors and Affiliations

  1. Laboratory Ion Channel Research, Campus Gasthuisberg, KU Leuven Department, Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Pharmakologie und Toxikologie, Universität des Saarlandes, Institut für Experimentelle u. Klinische, Homburg, Germany

    Veit Flockerzi

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Zanini, D., Göpfert, M.C. (2014). TRPs in Hearing. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 223. Springer, Cham. https://doi.org/10.1007/978-3-319-05161-1_7

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