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TRP Channels in Reproductive (Neuro)Endocrinology

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Mammalian Transient Receptor Potential (TRP) Cation Channels

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 223))

Abstract

Transient receptor potential (TRP) ion channels have been detected in neurons that are part of the neural network controlling reproductive physiology and behavior. In this chapter we will primarily take a look at the classical/canonical TRP (TRPC) channels but will also examine some other members of the TRP channel superfamily in reproductive (neuro)endocrinology. The referenced data suggest that different TRP proteins could play functional roles at different levels of the reproductive pathway. Still, our understanding of TRP channel involvement in (neuro)endocrinology is quite limited. Due to their mechanism of activation and complex regulation, these channels are however ideally suited to be part of the transduction machinery of hormone-secreting cells.

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Authors and Affiliations

  1. Department of Physiology, University of Saarland School of Medicine, 66421, Homburg, Germany

    Trese Leinders-Zufall

  2. Department of Pharmacology and Toxicology, University of Saarland School of Medicine, 66421, Homburg, Germany

    Ulrich Boehm

Authors
  1. Trese Leinders-Zufall
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  2. Ulrich Boehm
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Correspondence to Trese Leinders-Zufall .

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Editors and Affiliations

  1. Laboratory Ion Channel Research, Campus Gasthuisberg, KU Leuven Department, Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Pharmakologie und Toxikologie, Universität des Saarlandes, Institut für Experimentelle u. Klinische, Homburg, Germany

    Veit Flockerzi

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Leinders-Zufall, T., Boehm, U. (2014). TRP Channels in Reproductive (Neuro)Endocrinology. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 223. Springer, Cham. https://doi.org/10.1007/978-3-319-05161-1_16

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