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MicroRNA Targeted Cancer Therapy pp 99–114Cite as

miRNA Targeted Therapy in Lung Cancer

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Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that play critical role in many human diseases, including cancer, where they function as regulatory molecules. Lung cancer remains the leading cause of cancer-related deaths world-wide, which calls for a dire need to elucidate novel targets for early detection and therapy. In recent years, miRNAs have emerged as a class of molecular targets that can potentially be exploited for diagnosis, prognosis as well as therapy of lung cancer. The miRNAs are intricately involved in lung cancer relapse through their regulation of drug resistance and metastasis. This chapter summarizes the state-of-our-knowledge on the role of miRNAs in the progression as well as potential targets for lung cancer therapy. Since this is a rapidly evolving field, we will discuss the novel research published in last 1 year only. It is our hope that the promising pre-clinical results discussed here can quickly find their way to the clinic for the benefit of scores of patients battling with this deadly disease.

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Authors and Affiliations

  1. Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 707 Hudson Webber Cancer Research Center, Detroit, MI, 48201, USA

    Aamir Ahmad, Kevin R. Ginnebaugh, Yiwei Li, Bin Bao & Fazlul H. Sarkar

  2. Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, 4 Hudson Webber Cancer Research Center, Detroit, MI, 48201, USA

    Shirish M. Gadgeel & Fazlul H. Sarkar

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  1. Aamir Ahmad
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  2. Kevin R. Ginnebaugh
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  3. Yiwei Li
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  4. Bin Bao
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  5. Shirish M. Gadgeel
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  6. Fazlul H. Sarkar
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Correspondence to Aamir Ahmad .

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Editors and Affiliations

  1. Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Fazlul H. Sarkar

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Ahmad, A., Ginnebaugh, K.R., Li, Y., Bao, B., Gadgeel, S.M., Sarkar, F.H. (2014). miRNA Targeted Therapy in Lung Cancer. In: Sarkar, F. (eds) MicroRNA Targeted Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-05134-5_5

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