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Syntheses, Properties, and Applications of Fluorinated Isoquinolines

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Fluorine in Heterocyclic Chemistry Volume 2

Abstract

Fluorinated isoquinolines attract widespread attention as important components of pharmaceuticals and materials, because of their unique characteristics such as biological activities and light-emitting properties. Thus, a number of fluorinated isoquinolines have been synthesized. This chapter covers the syntheses, properties, and applications of ring-fluorinated isoquinolines starting from earlier studies, as well as the syntheses of pyridine-ring-trifluoromethylated isoquinolines. Modern synthetic methodologies for fluorinated isoquinolines have been greatly developed during last decade. These approaches are presented according to the classification based on the standpoint of organic synthesis: (i) the direct introduction of fluorine (or CF3 group) onto the isoquinoline ring, (ii) the construction of a fused pyridine ring via cyclization of a precursor bearing a pre-fluorinated benzene ring, and (iii) the simultaneous installation of an isoquinoline framework and a fluorine substituent. This chapter also presents a discussion of the application of fluorinated isoquinoline derivatives.

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Authors and Affiliations

  1. Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Japan

    Takeshi Fujita & Junji Ichikawa

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  1. Takeshi Fujita
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  2. Junji Ichikawa
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Correspondence to Junji Ichikawa .

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  1. Department of Chemistry, Moscow State University, Moscow, Russia

    Valentine Nenajdenko

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Fujita, T., Ichikawa, J. (2014). Syntheses, Properties, and Applications of Fluorinated Isoquinolines. In: Nenajdenko, V. (eds) Fluorine in Heterocyclic Chemistry Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-319-04435-4_4

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