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Gastroesophageal Reflux Disease: Pathophysiology

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Esophageal Diseases

Abstract

Gastroesophageal reflux disease (GERD) is a common disease with a variable prevalence ranging from 5 % in the Eastern population to 25 % in the West. Moreover, GERD incidence seems to be escalating.

Gastroesophageal reflux occurs daily in normal individuals (physiological reflux); however, it may become “a disease which develops when the reflux of stomach contents causes troublesome symptoms and/or complications” – or GERD – as defined by an International Consensus.

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Selected Reading

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Author information

Authors and Affiliations

  1. Department of Surgery, State University of Londrina, Av. Robert Koch, 60, Londrina, 86038-440, Brazil

    Antonio Carlos Valezi MD & Jorge Mali Junior MD

  2. Department of Surgery, Federal University of São Paulo, Rus Diogo de Faria 1087 cj 301, São Paulo, Brazil

    Fernando A. M. Herbella MD

Authors
  1. Antonio Carlos Valezi MD
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  2. Fernando A. M. Herbella MD
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  3. Jorge Mali Junior MD
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Corresponding author

Correspondence to Fernando A. M. Herbella MD .

Editor information

Editors and Affiliations

  1. Department of Surgery, Boston Veteran Administration Healthcare System, West Roxbury, MA, USA, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    P. Marco Fisichella

  2. Department of Surgical Sciences, University of Torino, Torino, Italy, Division of Biological Sciences, University of Chicago, Chicago, Illinois, USA

    Marco E. Allaix

  3. Department of Surgical Sciences, University of Torino, Turin, Italy

    Mario Morino

  4. Department of Surgery, Center for Esophageal Diseases, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA

    Marco G. Patti

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© 2014 Springer International Publishing Switzerland

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Valezi, A.C., Herbella, F.A.M., Junior, J.M. (2014). Gastroesophageal Reflux Disease: Pathophysiology. In: Fisichella, P., Allaix, M., Morino, M., Patti, M. (eds) Esophageal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-04337-1_3

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  • DOI: https://doi.org/10.1007/978-3-319-04337-1_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-04336-4

  • Online ISBN: 978-3-319-04337-1

  • eBook Packages: MedicineMedicine (R0)

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