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Mechanical Characterization of the Human Aorta: Experiments, Modeling and Simulation

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Computational Modeling, Optimization and Manufacturing Simulation of Advanced Engineering Materials

Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 49))

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Abstract

This chapter presents an overview of recent works aimed at characterizing the mechanical behaviour of the human aorta via experiments, modeling and simulation. The application of these techniques are in particular detailed in the analysis of the following cases: ascending aorta, aortic arch and thoracic descending aorta under in-vitro and in-vivo conditions. The experimental procedure encompasses uniaxial tension and pressurization tests on healthy and pathological tissues of different ages. The tensile measurements are used to calibrate the material parameters of isotropic or anisotropic quasi-static elastic constitutive models which are intended to predict the material response in a wide deformation range. Although this task is usually carried out analytically, numerical simulations (using a discretized formulation defined in the context of the finite element method) are also performed for problems in which more complex geometry, boundary conditions and loads are considered. Overall, the reported material characterization was found to provide a realistic description of the mechanical behaviour of the aorta subjected to various deformation and stress scenarios. Finally, the implication of these studies is the possibility to predict the mechanical response of the human aorta under generalized loading states like those that can occur in physiological conditions and/or in medical device applications.

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Acknowledgments

The authors wish to express their appreciation to Dr. R. Burgos and C. García-Montero of the Hospital de Puerta de Hierro at Madrid for the provision of arterial tissues analyzed in this work. The support provided by DICYT Project No. 051415GH of the Universidad de Santiago de Chile (USACH) is gratefully acknowledged.

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Authors and Affiliations

  1. Departamento de Ingeniería Mecánica, Universidad de Santiago de Chile, USACH, Av. Bernardo O’Higgins 3363, Santiago de Chile, Chile

    Claudio M. García-Herrera & Marcela A. Cruchaga

  2. Departamento de Ingeniería Mecánica y Metalúrgica, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Santiago de Chile, Chile

    Diego J. Celentano

  3. E.T.S.I. Caminos, Canales y Puertos, Universidad Politécnica de Madrid, C/ Profesor Aranguren s/n, Madrid, Spain

    Gustavo V. Guinea

Authors
  1. Claudio M. García-Herrera
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  2. Diego J. Celentano
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  3. Marcela A. Cruchaga
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  4. Gustavo V. Guinea
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Corresponding author

Correspondence to Claudio M. García-Herrera .

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Editors and Affiliations

  1. Department of Mechanical Engineering, Santa Catarina State Uni. - UDESC, Joinville, Santa Catarina, Brazil

    Pablo Andrés Muñoz-Rojas

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García-Herrera, C.M., Celentano, D.J., Cruchaga, M.A., Guinea, G.V. (2016). Mechanical Characterization of the Human Aorta: Experiments, Modeling and Simulation. In: Muñoz-Rojas, P. (eds) Computational Modeling, Optimization and Manufacturing Simulation of Advanced Engineering Materials. Advanced Structured Materials, vol 49. Springer, Cham. https://doi.org/10.1007/978-3-319-04265-7_7

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