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Preventing Ischemic Brain Injury after Sudden Cardiac Arrest Using NO Inhalation

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Annual Update in Intensive Care and Emergency Medicine 2014

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM,volume 2014))

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Abstract

Sudden cardiac arrest is a leading cause of death worldwide [1]. Despite advances in cardiopulmonary resuscitation (CPR) methods, including the introduction of the automatic electrical defibrillator (AED) and therapeutic hypothermia [2, 3], only about 10 % of adult out-of-hospital cardiac arrest (OHCA) victims survive to hospital discharge [4], and the majority of survivors have moderate to severe cognitive deficits 3 months after resuscitation [5]. Resuscitation from cardiac arrest is the ultimate whole body ischemia-reperfusion (I/R) injury affecting multiple organ systems including brain and heart [6]. No pharmacological agent is available to improve outcome from post-cardiac arrest syndrome.

Inhaled nitric oxide (NO) has been widely used for the treatment of neonatal hypoxemia with acute pulmonary hypertension. However, accumulating evidence has demonstrated that inhaled NO exerts beneficial effects on I/R injury in extrapulmonary organs without causing hypotension. Along these lines, we recently reported that inhaled NO improved outcomes after cardiac arrest/CPR in mice. This chapter provides insights into the potential salutary effects of inhaled NO in ischemic brain injury associated with sudden cardiac arrest.

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Authors and Affiliations

  1. Dept of Anesthesia and Intensive Care, Massachusetts General Hospital, Charlestown, MA, USA

    K. Kida & F. Ichinose

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  1. K. Kida
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  2. F. Ichinose
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Correspondence to F. Ichinose .

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  1. Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Louis Vincent Prof.

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Kida, K., Ichinose, F. (2014). Preventing Ischemic Brain Injury after Sudden Cardiac Arrest Using NO Inhalation. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2014. Annual Update in Intensive Care and Emergency Medicine, vol 2014. Springer, Cham. https://doi.org/10.1007/978-3-319-03746-2_34

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  • DOI: https://doi.org/10.1007/978-3-319-03746-2_34

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-03745-5

  • Online ISBN: 978-3-319-03746-2

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