Abstract
Intensive research and still much controversy on the adult mammalian heart’s capacity for self-renewal has finally brought a consensus that new cardiomyocytes are indeed formed throughout adult mammalian life. However, the physiological significance of this myocyte renewal, the origin of the new myocytes as well as the rate of adult myocyte turnover have been highly debated. Indeed, while some have calculated a yearly cardiomyocyte turnover of about 1 %, others calculated 4–10 % and some as high as 40 %/year. This very high spread on the “measured” values of such an important phenomenon raises questions about the conceptual and methodological approaches used so far. Recently, using an experimental protocol of severe diffuse myocardial damage, combined with several genetic murine models of fate mapping for cell lineage tracing along with cell transplantation approaches, we have ultimately demonstrated that the endogenous resident cardiac stem/progenitor cells (eCSCs) fulfil the criteria as the cell type necessary and sufficient for myocyte regeneration, leading to complete cellular, anatomical and functional myocardial recovery. The presence of this regenerative agent within the adult mammalian heart, including the human, supports the view that the heart has the potential to repair itself if the eCSCs can be properly stimulated. It is thus predicted that a better understanding of eCSC biology, in order to fully exploit their regeneration potential, will ultimately lead to developing realistic and clinically applicable myocardial regeneration strategies for cardiovascular diseases.
Keywords
- Hepatocyte Growth Factor
- Acute Myocardial Infarction
- Percutaneous Coronary Intervention
- Regenerative Therapy
- Allogeneic Cell
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Aquila, I. et al. (2014). Understanding Tissue Repair Through the Activation of Endogenous Resident Stem Cells. In: Brevini, T. (eds) Stem Cells in Animal Species: From Pre-clinic to Biodiversity. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-03572-7_2
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